{
  "id": 48,
  "label": "insulin",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "CHEBI:145810",
  "properties": {
    "definition": "A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the β cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 64,
      "label": "polypeptide",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        86,
        420
      ],
      "type_id": 0,
      "properties": {
        "definition": "A peptide containing ten or more amino acid residues."
      },
      "child_count": 6,
      "reference_id": "CHEBI:15841"
    },
    {
      "id": 193,
      "label": "heterodetic cyclic peptide",
      "isLeaf": false,
      "isRoot": true,
      "parents": [],
      "type_id": 0,
      "properties": {
        "definition": "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond."
      },
      "child_count": 1,
      "reference_id": "CHEBI:24533"
    },
    {
      "id": 233,
      "label": "peptide hormone",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        86
      ],
      "type_id": 0,
      "properties": {
        "definition": "Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine."
      },
      "child_count": 2,
      "reference_id": "CHEBI:25905"
    }
  ],
  "children": [
    {
      "id": 721,
      "label": "insulin (human)",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        48
      ],
      "type_id": 0,
      "properties": {
        "definition": "An insulin that is produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two peptide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into <em>E. coli</em>, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes."
      },
      "child_count": 0,
      "reference_id": "CHEBI:5931"
    }
  ],
  "roots": [
    {
      "id": 64,
      "label": "polypeptide"
    },
    {
      "id": 193,
      "label": "heterodetic cyclic peptide"
    },
    {
      "id": 233,
      "label": "peptide hormone"
    }
  ]
}