{
  "id": 2700,
  "label": "adrenocortical insufficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000004",
  "properties": {
    "xrefs": [
      "DOID:10493",
      "EFO:0009491",
      "ICD9:255.4",
      "ICD9:255.41",
      "MEDGEN:589758",
      "MESH:D000309",
      "NCIT:C26691",
      "SCTID:386584007",
      "UMLS:C0405580",
      "icd11.foundation:733056203"
    ],
    "synonyms": [
      "adrenal cortical hypofunction",
      "adrenal cortical insufficiency",
      "adrenal gland insufficiency",
      "adrenal insufficiency",
      "adrenocortical insufficiency",
      "hypocortisolemia",
      "hypocortisolism",
      "hypoadrenalism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4842,
      "label": "adrenal cortex disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3952",
          "MEDGEN:154",
          "MESH:D000303",
          "SCTID:129636003",
          "UMLS:C0001614"
        ],
        "synonyms": [
          "adrenal cortex disease",
          "adrenal cortex disease or disorder",
          "disease of adrenal cortex",
          "disease or disorder of adrenal cortex",
          "disorder of adrenal cortex"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the adrenal cortex."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002816"
    }
  ],
  "children": [
    {
      "id": 16073,
      "label": "primary adrenal insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019802",
          "MEDGEN:854614",
          "MedDRA:10052381",
          "NCIT:C113172",
          "Orphanet:101958",
          "UMLS:C3887896"
        ],
        "synonyms": [
          "Addison's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormonal disorder that occurs when the adrenal glands fail to release adequate amounts of glucocorticoids (cortisol), mineralocorticoids (aldosterone, 11-deoxycorticosterone), and androgens (dehydroepiandrosterone) to meet physiologic needs, despite release of ACTH from the pituitary."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015128"
    },
    {
      "id": 23205,
      "label": "secondary adrenal insufficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2700
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:184925",
          "NCIT:C62602",
          "SCTID:16685009",
          "UMLS:C0948387"
        ],
        "synonyms": [
          "central Hypoadrenalism",
          "central adrenal insufficiency",
          "hypocortisolism secondary to another disorder",
          "secondary adrenal insufficiency",
          "secondary adrenocortical insufficiency",
          "secondary hypocortisolism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormonal disorder that occurs when lack of corticotropin-releasing hormone (CRH) secretion from the hypothalamus or adrenocorticotropic hormone (ACTH) secretion from the pituitary is responsible for hypofunction of the adrenal cortex."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043370"
    }
  ],
  "roots": [
    {
      "id": 4842,
      "label": "adrenal cortex disorder"
    }
  ]
}