{
  "id": 2721,
  "label": "precocious puberty",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000088",
  "properties": {
    "xrefs": [
      "HP:0000826",
      "ICD10CM:E30.1",
      "ICD9:259.1",
      "MEDGEN:18752",
      "MESH:D011629",
      "MedDRA:10044701",
      "MedDRA:10058084",
      "NANDO:2100135",
      "NCIT:C79704",
      "Orphanet:95708",
      "SCTID:400179000",
      "UMLS:C0034013"
    ],
    "synonyms": [
      "pubertas praecox",
      "sexual precocity",
      "familial precocious puberty",
      "idiopathic sexual precocity"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Unusually early sexual maturity."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4375,
      "label": "gonadal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2277",
          "MEDGEN:9074",
          "MESH:D006058",
          "NCIT:C26786",
          "UMLS:C0018050"
        ],
        "synonyms": [
          "disease of gonad",
          "disease or disorder of gonad",
          "disorder of gonad",
          "disorder of gonads",
          "gonad disease",
          "gonad disease or disorder",
          "gonadal disorder",
          "gonadal disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the testis or the ovary."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002259"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [
    {
      "id": 16544,
      "label": "peripheral precocious puberty",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020141",
          "MEDGEN:1842596",
          "NANDO:2200378",
          "Orphanet:178040",
          "SCTID:736606009",
          "UMLS:C5680513",
          "icd11.foundation:1495024153"
        ],
        "synonyms": [
          "GIPP",
          "gonadotropin independent precocious puberty",
          "gonadotropin-independent precocious puberty",
          "precocious pseudopuberty"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Precocious puberty caused by sex hormones."
      },
      "child_count": 1,
      "reference_id": "MONDO:0015791"
    },
    {
      "id": 18572,
      "label": "precocious puberty in female",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "HP:0010465",
          "MEDGEN:543449",
          "Orphanet:435561",
          "UMLS:C0271616"
        ],
        "synonyms": [
          "female organism precocious puberty",
          "precocious puberty of female organism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A precocious puberty that involves the female organism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018561"
    },
    {
      "id": 19041,
      "label": "central precocious puberty",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2721,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112308",
          "EFO:0009029",
          "GARD:0016546",
          "ICD9:259.1",
          "MEDGEN:90985",
          "MESH:C562787",
          "NANDO:1200381",
          "NANDO:2200377",
          "OMIMPS:176400",
          "Orphanet:650063",
          "Orphanet:759",
          "SCTID:237816004",
          "UMLS:C0342543",
          "icd11.foundation:1749914533"
        ],
        "synonyms": [
          "gonadotropin-dependant precocious puberty",
          "gonadotropin-dependent precocious puberty",
          "precocious puberty, central"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Central precocious puberty (CPP), also referred to as gonadotropin dependent precocious puberty, is an endocrine-related developmental disease characterized by the onset of pubertal changes, with development of secondary sexual characteristics and accelerated growth and bone maturation, before the normal age of puberty (8 years in girls and 9 years in boys)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019165"
    }
  ],
  "roots": [
    {
      "id": 4375,
      "label": "gonadal disorder"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}