{
  "id": 2770,
  "label": "striatal degeneration, autosomal dominant",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000211",
  "properties": {
    "xrefs": [
      "GARD:0017146",
      "MEDGEN:322971",
      "MESH:C563783",
      "OMIMPS:609161",
      "Orphanet:228169",
      "UMLS:C1836694"
    ],
    "synonyms": [
      "ADSD",
      "autosomal dominant striatal neurodegeneration"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An adult-onset movement disorder characterized by bradykinesia, dysarthria and muscle rigidity."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5100,
      "label": "striatonigral degeneration",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9146,
        18954,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4751",
          "GARD:0023374",
          "ICD10CM:G23.2",
          "ICD9:333.0",
          "MEDGEN:124366",
          "MESH:D020955",
          "NCIT:C125695",
          "OMIMPS:271930",
          "SCTID:29618004",
          "UMLS:C0270733",
          "icd11.foundation:195535779"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive neurodegenerative disorder caused by a disruption in the connection between the striatum and the substantia nigra. It is a type of multiple system atrophy (MSA). Signs and symptoms include rigidity, instability, impaired speech, and slow movements."
      },
      "child_count": 9,
      "reference_id": "MONDO:0003122"
    }
  ],
  "children": [
    {
      "id": 13266,
      "label": "autosomal dominant striatal neurodegeneration type 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2770,
        20335
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024853",
          "MEDGEN:934775",
          "OMIM:609161",
          "SCTID:725392005",
          "UMLS:C4310808"
        ],
        "synonyms": [
          "ADSD1",
          "PDE8B striatal degeneration, autosomal dominant",
          "striatal Degeneration, autosomal dominant 1",
          "striatal degeneration, autosomal dominant 1",
          "striatal degeneration, autosomal dominant caused by mutation in PDE8B",
          "ADSD",
          "autosomal dominant striatal neurodegeneration",
          "striatal degeneration, autosomal dominant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Autosomal dominant striatal degeneration is a neurologic disorder characterized by variable movement abnormalities due to dysfunction in the striatal part of the basal ganglia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012205"
    },
    {
      "id": 15819,
      "label": "striatal degeneration, autosomal dominant 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2770
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060998",
          "GARD:0025021",
          "MEDGEN:934758",
          "OMIM:616922",
          "UMLS:C4310791"
        ],
        "synonyms": [
          "striatal degeneration, autosomal dominant",
          "ADSD2",
          "PDE10A striatal degeneration, autosomal dominant",
          "striatal Degeneration, autosomal dominant 2",
          "striatal Degeneration, autosomal dominant type 2",
          "striatal degeneration, autosomal dominant 2; ADSD2",
          "striatal degeneration, autosomal dominant caused by mutation in PDE10A"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any striatal degeneration, autosomal dominant in which the cause of the disease is a mutation in the PDE10A gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014835"
    }
  ],
  "roots": [
    {
      "id": 5100,
      "label": "striatonigral degeneration"
    }
  ]
}