{
  "id": 2868,
  "label": "extrapulmonary tuberculosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000368",
  "properties": {
    "xrefs": [
      "DOID:0050598",
      "GARD:0022756",
      "MEDGEN:671310",
      "SCTID:423997002",
      "UMLS:C0679362"
    ],
    "definition": "A tuberculosis that occurs at body sites other than the lung."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 18237,
      "label": "tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2837,
        20027
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:399",
          "GARD:0007827",
          "ICD10CM:A15-A19",
          "ICD10WHO:A15-A19",
          "ICD9:017.90",
          "ICD9:017.92",
          "ICD9:017.94",
          "ICD9:017.96",
          "MEDGEN:22513",
          "MESH:D014376",
          "MedDRA:10044755",
          "NCIT:C3423",
          "NORD:1801",
          "Orphanet:3389",
          "SCTID:56717001",
          "UMLS:C0041296",
          "icd11.foundation:2072728114"
        ],
        "synonyms": [
          "tuberculosis disease",
          "active tuberculosis",
          "Kochs disease",
          "TB"
        ],
        "definition": "A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use."
      },
      "child_count": 24,
      "reference_id": "MONDO:0018076"
    }
  ],
  "children": [
    {
      "id": 2869,
      "label": "abdominal tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050599",
          "GARD:0022757",
          "ICD9:014.80",
          "MEDGEN:677012",
          "SCTID:447330002",
          "UMLS:C0740652"
        ],
        "synonyms": [
          "tuberculosis of abdomen"
        ],
        "definition": "An extrapulmonary tuberculosis that is located in gastrointestinal tract, located in peritoneum, located in omentum, located in mesentery, located in liver, located in spleen or located in pancreas."
      },
      "child_count": 5,
      "reference_id": "MONDO:0000369"
    },
    {
      "id": 3141,
      "label": "cardiac tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2868,
        6967
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060570",
          "GARD:0022831",
          "MEDGEN:1830134",
          "MESH:D014381",
          "UMLS:C5704594"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Pathological conditions of the cardiovascular system caused by infection of mycobacterium tuberculosis. Tuberculosis involvement may include the heart; the blood vessels; or the pericardium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000813"
    },
    {
      "id": 7327,
      "label": "central nervous system tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1638",
          "EFO:0007199",
          "GARD:0024220",
          "ICD9:013.2",
          "ICD9:013.20",
          "ICD9:013.35",
          "MEDGEN:82907",
          "Orphanet:641396",
          "SCTID:186217006",
          "UMLS:C0275904",
          "icd11.foundation:729372485"
        ],
        "synonyms": [
          "central nervous system tuberculosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with seizures, focal neurologic deficits, and intracranial hypertension. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as opportunistic infections, but also occur in immunocompetent individuals."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005696"
    },
    {
      "id": 7388,
      "label": "gastrointestinal tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868,
        23208
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:404",
          "EFO:0007280",
          "GARD:0024230",
          "ICD9:014.80",
          "ICD9:014.81",
          "ICD9:014.86",
          "MEDGEN:52885",
          "MESH:D014385",
          "SCTID:186225008",
          "UMLS:C0041312"
        ],
        "synonyms": [
          "tuberculosis of intestines, peritoneum, and mesenteric glands"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Tuberculosis that involves any region of the gastrointestinal tract, mostly in the distal ileum and the cecum. In most cases, mycobacterium tuberculosis is the pathogen. Clinical features include abdominal pain; fever; and palpable mass in the ileocecal area."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005768"
    },
    {
      "id": 7433,
      "label": "laryngeal tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2868,
        4698,
        21378
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1583",
          "EFO:0007337",
          "GARD:0024235",
          "ICD9:012.3",
          "ICD9:012.30",
          "ICD9:012.31",
          "ICD9:012.32",
          "MEDGEN:11945",
          "MESH:D014387",
          "NCIT:C26895",
          "SCTID:70341005",
          "UMLS:C0041315"
        ],
        "synonyms": [
          "larynx tuberculosis",
          "tuberculous laryngitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Extrapulmonary tuberculosis involving the larynx. Signs and symptoms include hoarseness, cough, and odynophagia. The condition is rare."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005819"
    },
    {
      "id": 7445,
      "label": "lymph node tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2868,
        6675
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4889",
          "EFO:0007350",
          "GARD:0024238",
          "ICD10CM:A18.2",
          "MEDGEN:11946",
          "MESH:D014388",
          "NCIT:C26896",
          "SCTID:10893003",
          "UMLS:C0041316"
        ],
        "synonyms": [
          "lymph node tuberculosis",
          "tuberculous adenitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Tuberculosis of the lymph node."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005831"
    },
    {
      "id": 7460,
      "label": "miliary tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9861",
          "EFO:0007368",
          "GARD:0024243",
          "ICD10CM:A19",
          "ICD10WHO:A19",
          "ICD9:018",
          "ICD9:018.80",
          "ICD9:018.9",
          "ICD9:018.90",
          "MEDGEN:21726",
          "MESH:D014391",
          "NCIT:C35086",
          "SCTID:47604008",
          "UMLS:C0041321",
          "icd11.foundation:861638547"
        ],
        "synonyms": [
          "acute miliary tuberculosis",
          "disseminated tuberculosis",
          "generalised tuberculosis",
          "generalized tuberculosis"
        ],
        "definition": "I would say the hematogenous widespread dissemination of tuberculosis in the body. The term derives from the chest X-ray image of the tiny (1-5 mm) tuberculosis lesions which are seen through out the lung parenchyma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005848"
    },
    {
      "id": 7505,
      "label": "pericardial tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2868,
        7506
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4962",
          "EFO:0007426",
          "GARD:0024252",
          "ICD9:017.90",
          "MEDGEN:18379",
          "MESH:D010495",
          "SCTID:67256000",
          "UMLS:C0031049",
          "icd11.foundation:2135325100"
        ],
        "synonyms": [
          "tuberculous pericarditis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Inflammation of the sac surrounding the heart (pericardium) due to mycobacterium tuberculosis infection. Pericarditis can lead to swelling (pericardial effusion), compression of the heart (cardiac tamponade), and preventing normal beating of the heart."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005903"
    },
    {
      "id": 7524,
      "label": "pleural tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868,
        3253,
        21378
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:106",
          "EFO:0007446",
          "GARD:0024256",
          "ICD10CM:A15.6",
          "ICD9:010.1",
          "ICD9:010.10",
          "ICD9:010.12",
          "ICD9:010.16",
          "ICD9:012.0",
          "ICD9:012.00",
          "MEDGEN:22517",
          "MESH:D014396",
          "NCIT:C26898",
          "SCTID:186172004",
          "UMLS:C0041326"
        ],
        "synonyms": [
          "pleura tuberculosis",
          "tuberculosis of pleura",
          "tuberculous pleurisy",
          "tuberculous pleuritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Inflammation of the pleura secondary to an infection with Mycobacterium tuberculosis."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005922"
    },
    {
      "id": 7554,
      "label": "skeletal tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868,
        6893
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1639",
          "EFO:0007487",
          "GARD:0024264",
          "ICD9:015",
          "ICD9:015.9",
          "MEDGEN:21727",
          "MESH:D014394",
          "SCTID:17653001",
          "UMLS:C0041324"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Tuberculosis of the bones or joints."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005962"
    },
    {
      "id": 7593,
      "label": "urogenital tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2149",
          "EFO:0007531",
          "GARD:0024270",
          "ICD9:016",
          "ICD9:016.9",
          "ICD9:016.90",
          "ICD9:016.92",
          "MEDGEN:11950",
          "MESH:D014401",
          "SCTID:4445009",
          "UMLS:C0041333"
        ],
        "synonyms": [
          "genitourinary system tuberculosis"
        ],
        "definition": "A general term for mycobacterium infections of any part of the urogenital system in either the male or the female."
      },
      "child_count": 7,
      "reference_id": "MONDO:0006002"
    },
    {
      "id": 8315,
      "label": "ocular tuberculosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2868,
        23257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070344",
          "EFO:1001070",
          "GARD:0024495",
          "ICD9:017.30",
          "ICD9:017.32",
          "MEDGEN:52887",
          "MESH:D014392",
          "SCTID:49107007",
          "UMLS:C0041322"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Tuberculous infection of the eye, primarily the iris, ciliary body, and choroid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006876"
    },
    {
      "id": 20789,
      "label": "cutaneous tuberculosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2868,
        21329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025357",
          "MEDGEN:22515",
          "SCTID:66986005",
          "UMLS:C0041309",
          "icd11.foundation:625292625"
        ],
        "synonyms": [
          "cutaneous tuberculosis",
          "tuberculosis of skin",
          "Cutaneous Tuberculoses",
          "Cutaneous Tuberculosis",
          "Cutaneous tuberculosis",
          "Skin Tuberculoses",
          "Skin Tuberculosis",
          "Tuberculoderma",
          "Tuberculoses, Cutaneous",
          "Tuberculoses, Skin",
          "Tuberculosis cutis",
          "Tuberculosis of skin",
          "Tuberculosis, Cutaneous",
          "Tuberculosis, Skin",
          "tuberculoderma",
          "tuberculosis cutis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0021948"
    }
  ],
  "roots": [
    {
      "id": 18237,
      "label": "tuberculosis"
    }
  ]
}