{
  "id": 2885,
  "label": "digestive system neuroendocrine tumor, grade 1/2",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000386",
  "properties": {
    "xrefs": [
      "DOID:0050626",
      "GARD:0022761",
      "MEDGEN:443945",
      "NCIT:C95404",
      "ONCOTREE:GINET",
      "UMLS:C2930967"
    ],
    "synonyms": [
      "alimentary part of gastrointestinal system neuroendocrine tumor",
      "alimentary part of gastrointestinal system neuroendocrine tumour",
      "digestive system NET",
      "digestive system neuroendocrine tumor",
      "digestive system neuroendocrine tumour",
      "digestive system well differentiated neuroendocrine tumor",
      "digestive system well differentiated neuroendocrine tumour",
      "gastroenteropancreatic NET",
      "gastroenteropancreatic neuroendocrine tumor",
      "gastroenteropancreatic neuroendocrine tumour",
      "gastrointestinal NET",
      "gastrointestinal neuroendocrine tumor",
      "gastrointestinal neuroendocrine tumors",
      "gastrointestinal neuroendocrine tumour",
      "gastrointestinal neuroendocrine tumours",
      "gastrointestinal system neuroendocrine tumor",
      "gastrointestinal system neuroendocrine tumour",
      "malignant gastrointestinal neuroendocrine tumor",
      "malignant gastrointestinal neuroendocrine tumour",
      "GINET"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 21456,
      "label": "digestive system neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        19314,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002437",
          "MEDGEN:232237",
          "MESH:C535650",
          "NCIT:C27721",
          "Orphanet:100092",
          "UMLS:C1333799"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system NET",
          "alimentary part of gastrointestinal system neuroendocrine neoplasm",
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumor, well differentiated, low or intermediate grade",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "carcinoid tumor of digestive system",
          "carcinoid tumour of digestive system",
          "digestive system NET",
          "digestive system neuroendocrine neoplasm",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumor, well differentiated, low or intermediate grade",
          "digestive system neuroendocrine tumour",
          "gastro-enteropancreatic neuroendocrine tumor",
          "gastro-enteropancreatic neuroendocrine tumour",
          "gastroenteropancreatic endocrine tumor",
          "gastroenteropancreatic endocrine tumour",
          "gastroenteropancreatic neuroendocrine neoplasm",
          "gastrointestinal neuroendocrine neoplasm",
          "gastrointestinal system neuroendocrine neoplasm",
          "neuroendocrine neoplasm of alimentary part of gastrointestinal system",
          "neuroendocrine neoplasm of digestive system",
          "GEP tumors",
          "GEP tumours",
          "GEP-NEN",
          "GEP-NET",
          "carcinoid tumor",
          "carcinoid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas)."
      },
      "child_count": 21,
      "reference_id": "MONDO:0024503"
    }
  ],
  "children": [
    {
      "id": 4994,
      "label": "small intestine neuroendocrine tumor, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        18542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0023316",
          "MEDGEN:474161",
          "NCIT:C96061",
          "UMLS:C3272528"
        ],
        "synonyms": [
          "small intestinal NET",
          "small intestinal neuroendocrine tumor",
          "small intestinal neuroendocrine tumour",
          "small intestinal well differentiated endocrine tumor",
          "small intestinal well differentiated endocrine tumour",
          "small intestine neuroendocrine tumor",
          "small intestine neuroendocrine tumour",
          "small intestinal well differentiated endocrine tumor/carcinoma",
          "carcinoid tumor of small intestine",
          "carcinoid tumour of small intestine"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the small intestine."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002995"
    },
    {
      "id": 5434,
      "label": "gastrin-producing neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5577",
          "GARD:0023546",
          "ICDO:8153/1",
          "MEDGEN:6551",
          "NANDO:2200395",
          "NCIT:C3050",
          "UMLS:C0017150",
          "icd11.foundation:1333125891"
        ],
        "synonyms": [
          "G cell tumor",
          "G cell tumour",
          "G-cell gastrin producing tumor",
          "G-cell gastrin producing tumour",
          "G-cell tumor",
          "G-cell tumour",
          "gastrin cell tumor",
          "gastrin secreting tumor",
          "gastrin secreting tumour",
          "gastrin-producing NET",
          "gastrin-producing neuroendocrine tumor",
          "gastrinoma",
          "malignant gastrinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A gastrin-producing neuroendocrine tumor. It is usually located in the pancreas but it is also found at other anatomic sites, including the stomach and small intestine."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003523"
    },
    {
      "id": 5537,
      "label": "esophageal neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        20522
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5784",
          "GARD:0022058",
          "MEDGEN:459486",
          "NCIT:C95616",
          "Orphanet:506136",
          "UMLS:C2987260",
          "icd11.foundation:1167478749",
          "icd11.foundation:890879256"
        ],
        "synonyms": [
          "NEN of esophagus",
          "NEN of oesophagus",
          "esophageal NEN",
          "esophageal NET",
          "esophageal neuroendocrine neoplasm",
          "esophageal neuroendocrine tumor",
          "esophageal well differentiated endocrine tumor",
          "esophageal well differentiated endocrine tumor/carcinoma",
          "esophageal well differentiated endocrine tumour",
          "esophagus NET",
          "esophagus neuroendocrine neoplasm",
          "esophagus neuroendocrine tumor",
          "esophagus neuroendocrine tumor, well differentiated, low or intermediate grade",
          "neuroendocrine neoplasm of esophagus",
          "neuroendocrine neoplasm of oesophagus",
          "neuroendocrine tumour of oesophagus",
          "oesophagus NET",
          "oesophagus neuroendocrine neoplasm",
          "oesophagus neuroendocrine tumor, well differentiated, low or intermediate grade",
          "oesophagus neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the esophagus."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003649"
    },
    {
      "id": 6033,
      "label": "L-cell glucagon-like peptide-producing neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7402",
          "GARD:0023879",
          "ICDO:8152/1",
          "MEDGEN:475773",
          "NCIT:C27448",
          "UMLS:C3274140"
        ],
        "synonyms": [
          "L-cell glucagon-like peptide-producing NET",
          "L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "L-cell glucagon-like peptide producing tumor",
          "L-cell glucagon-like peptide producing tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor that arises from the gastrointestinal tract and produces glucagon-like peptides. Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004211"
    },
    {
      "id": 16036,
      "label": "gastric neuroendocrine tumor, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        5092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025056",
          "MEDGEN:474032",
          "NCIT:C95871",
          "ONCOTREE:SWDNET",
          "UMLS:C3272399"
        ],
        "synonyms": [
          "GNET",
          "gastric NET",
          "gastric NET G1/2",
          "gastric neuroendocrine tumor",
          "gastric neuroendocrine tumour",
          "gastric well differentiated endocrine tumor",
          "gastric well differentiated endocrine tumor/carcinoma",
          "gastric well differentiated endocrine tumour",
          "well-differentiated neuroendocrine tumors of the stomach",
          "well-differentiated neuroendocrine tumours of the stomach"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the stomach."
      },
      "child_count": 10,
      "reference_id": "MONDO:0015062"
    },
    {
      "id": 16041,
      "label": "neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        4895,
        21434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025057",
          "MEDGEN:1617490",
          "NCIT:C135212",
          "UMLS:C4525742"
        ],
        "synonyms": [
          "carcinoid tumor of colon",
          "carcinoid tumour of colon",
          "colon neuroendocrine tumor",
          "colon neuroendocrine tumour",
          "neuroendocrine neoplasm of the colon",
          "NET of the colon",
          "colonic NET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the colon."
      },
      "child_count": 9,
      "reference_id": "MONDO:0015067"
    },
    {
      "id": 16042,
      "label": "rectal neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        5534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025058",
          "MEDGEN:1810164",
          "NCIT:C135213",
          "Orphanet:100081",
          "UMLS:C5554035"
        ],
        "synonyms": [
          "neuroendocrine tumor of rectum, well differentiated, low or intermediate grade",
          "rectal well differentiated neuroendocrine neoplasm",
          "rectal well-differentiated neuroendocrine neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the rectum."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015068"
    },
    {
      "id": 16047,
      "label": "gallbladder neuroendocrine tumor, grade 1/2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2885,
        20541,
        21455
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019761",
          "MEDGEN:474749",
          "NCIT:C96918",
          "Orphanet:100086",
          "UMLS:C3273116"
        ],
        "synonyms": [
          "gallbladder NET",
          "gallbladder neuroendocrine tumor",
          "gallbladder neuroendocrine tumour",
          "gallbladder well differentiated endocrine tumor",
          "gallbladder well differentiated endocrine tumor/carcinoma",
          "gallbladder well differentiated endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the gallbladder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015073"
    },
    {
      "id": 19671,
      "label": "pancreatic neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        7431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000045",
          "GARD:0013034",
          "ICDO:8150/1",
          "MEDGEN:277875",
          "NCIT:C27720",
          "ONCOTREE:PANET",
          "Orphanet:97253",
          "UMLS:C1337011"
        ],
        "synonyms": [
          "islet cell tumor",
          "islet cell tumors - pancreas",
          "islet cell tumors of the pancreas",
          "islet cell tumour",
          "islet cell tumours - pancreas",
          "islet cell tumours of the pancreas",
          "pancreatic NET",
          "pancreatic neuroendocrine tumor",
          "well differentiated pancreatic endocrine neoplasm",
          "well differentiated pancreatic endocrine tumor",
          "well differentiated pancreatic endocrine tumour",
          "well-differentiated NEN of pancreas",
          "well-differentiated neuroendocrine neoplasm of pancreas",
          "well-differentiated pancreatic NEN",
          "well-differentiated pancreatic neuroendocrine neoplasm",
          "PANET",
          "neuroendocrine tumor of pancreas",
          "neuroendocrine tumour of pancreas",
          "pancreatic endocrine tumor",
          "pancreatic endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pancreatic endocrine tumor, also known as pancreatic neuroendocrine tumor (PNET), describes a group of endocrine tumors originating in the pancreas that are usually indolent and benign, but may have the potential to be malignant. They can be functional, exhibiting a hormonal hypersecretion syndrome, but can be non-functional presenting with non-specific symptoms and include insulinoma, glucagonoma, VIPoma, somatostatinoma (SSoma), PPoma and Zollinger-Ellison syndrome (ZES, or gastrinoma) and other ectopic hormone producing tumors (such as GRFoma)."
      },
      "child_count": 22,
      "reference_id": "MONDO:0019954"
    },
    {
      "id": 20650,
      "label": "intestinal neuroendocrine tumor G1",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        4896,
        7051
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025331",
          "MEDGEN:138099",
          "MESH:C562842",
          "NCIT:C4637",
          "OMIM:114900",
          "SCTID:276816003",
          "UMLS:C0349535"
        ],
        "synonyms": [
          "carcinoid tumor of intestine",
          "carcinoid tumor of the intestine",
          "carcinoid tumour of intestine",
          "carcinoid tumour of the intestine",
          "grade 1 neuroendocrine neoplasm of intestine",
          "intestinal NET G1",
          "intestinal carcinoid tumor",
          "intestinal carcinoid tumour",
          "intestinal neuroendocrine tumor G1",
          "intestine NET G1",
          "intestine carcinoid tumor",
          "intestine carcinoid tumor (disease)",
          "intestine carcinoid tumour",
          "intestine carcinoid tumour (disease)",
          "intestine neuroendocrine neoplasm G1",
          "intestine neuroendocrine tumor, well differentiated, low grade"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the small or large intestine. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021533"
    }
  ],
  "roots": [
    {
      "id": 21456,
      "label": "digestive system neuroendocrine neoplasm"
    }
  ]
}