{
  "id": 2957,
  "label": "tongue squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000500",
  "properties": {
    "xrefs": [
      "DOID:0050865",
      "GARD:0022779",
      "MEDGEN:91153",
      "NCIT:C4648",
      "SCTID:276952000",
      "UMLS:C0349566"
    ],
    "synonyms": [
      "scc of the tongue",
      "scc of tongue",
      "squamous cell carcinoma of the tongue",
      "squamous cell carcinoma of tongue",
      "tongue scc",
      "tongue squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      },
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "A squamous cell carcinoma that arises from the tongue. It usually presents as a painful ulcerated or nodular lesion. The size of the tumor and the status of the lymph nodes are the most important factors that determine prognosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6418,
      "label": "tongue cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3050,
        7170,
        7266,
        20449
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8649",
          "GARD:0027692",
          "ICD9:141",
          "ICD9:141.0",
          "ICD9:141.1",
          "ICD9:141.2",
          "ICD9:141.3",
          "ICD9:141.4",
          "ICD9:141.5",
          "ICD9:141.6",
          "ICD9:141.9",
          "MEDGEN:102262",
          "MESH:D014062",
          "NCIT:C9345",
          "SCTID:363360003",
          "UMLS:C0153349"
        ],
        "synonyms": [
          "cancer of tongue",
          "malignant neoplasm of tongue",
          "malignant tongue neoplasm",
          "malignant tongue tumor",
          "malignant tongue tumour",
          "malignant tumor of the tongue",
          "malignant tumor of tongue",
          "malignant tumour of the tongue",
          "malignant tumour of tongue",
          "tongue cancer",
          "tongue neoplasm malignant",
          "tongue neoplasm, malignant",
          "malignant neoplasm of anterior 2/3 of tongue",
          "malignant neoplasm of anterior two-thirds of tongue",
          "malignant neoplasm of anterior two-thirds of tongue, part unspecified",
          "malignant neoplasm of base of tongue",
          "malignant neoplasm of border of tongue",
          "malignant neoplasm of dorsal surface of tongue",
          "malignant neoplasm of dorsal tongue",
          "malignant neoplasm of dorsal tongue NOS",
          "malignant neoplasm of dorsum of tongue",
          "malignant neoplasm of fixed part of tongue",
          "malignant neoplasm of fixed part of tongue NOS",
          "malignant neoplasm of junctional zone of tongue",
          "malignant neoplasm of mobile part of tongue",
          "malignant neoplasm of mobile part of tongue NOS",
          "malignant neoplasm of other sites of tongue",
          "malignant neoplasm of the tongue",
          "malignant neoplasm of tip and lateral border of tongue",
          "malignant neoplasm of tip and/or lateral border of tongue",
          "malignant neoplasm of tongue NOS",
          "malignant neoplasm of tongue, NOS",
          "malignant neoplasm of tongue, tip and lateral border",
          "malignant neoplasm of ventral surface of tongue",
          "malignant neoplasm of ventral tongue surface",
          "malignant tumor of anterior two-thirds of tongue",
          "malignant tumor of base of tongue",
          "malignant tumor of lingual tonsil",
          "malignant tumor of mobile part of tongue",
          "malignant tumor of posterior tongue",
          "malignant tumour of anterior two-thirds of tongue",
          "malignant tumour of base of tongue",
          "malignant tumour of lingual tonsil",
          "malignant tumour of mobile part of tongue",
          "malignant tumour of posterior tongue",
          "tongue neoplasm malignant stage unspecified",
          "malignant neoplasm of lingual tonsil",
          "malignant tumor of lingual tonsil (disorder)",
          "malignant tumour of lingual tonsil (disorder)",
          "tongue carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004631"
    },
    {
      "id": 6701,
      "label": "oral cavity squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23401,
        23483
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050866",
          "EFO:0000199",
          "GARD:0017932",
          "MEDGEN:108436",
          "NCIT:C4833",
          "ONCOTREE:OCSC",
          "Orphanet:502363",
          "SCTID:307502000",
          "UMLS:C0585362"
        ],
        "synonyms": [
          "mouth scc",
          "mouth squamous cell carcinoma",
          "oral cavity scc",
          "oral cavity squamous cell cancer",
          "oral cavity squamous cell carcinoma",
          "scc of mouth",
          "scc of oral cavity",
          "scc of the mouth",
          "scc of the oral cavity",
          "squamous cell carcinoma of mouth",
          "squamous cell carcinoma of oral cavity",
          "squamous cell carcinoma of the mouth",
          "squamous cell carcinoma of the oral cavity",
          "OCSC",
          "oral squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the oral cavity. It affects predominantly adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with signs and symptoms of locally advanced disease including mucosal ulceration, pain, difficulty with speaking, chewing, and swallowing, bleeding, weight loss, and neck swelling. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status."
      },
      "child_count": 14,
      "reference_id": "MONDO:0004958"
    }
  ],
  "children": [
    {
      "id": 18691,
      "label": "squamous cell carcinoma of the oral tongue",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2957
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025133",
          "NCIT:C8169",
          "Orphanet:457252"
        ],
        "synonyms": [
          "OTSCC",
          "oral tongue squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018708"
    }
  ],
  "roots": [
    {
      "id": 6418,
      "label": "tongue cancer"
    },
    {
      "id": 6701,
      "label": "oral cavity squamous cell carcinoma"
    }
  ]
}