{
  "id": 2963,
  "label": "synucleinopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000510",
  "properties": {
    "xrefs": [
      "DOID:0050890",
      "GARD:0022781",
      "MEDGEN:1682194",
      "MESH:D000080874",
      "UMLS:C5191670"
    ],
    "synonyms": [
      "alpha synucleinopathies",
      "synucleinopathies"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibers or glial cells. [url:http://en.wikipedia.org/wiki/Synucleinopathies ]"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7208,
      "label": "neurodegenerative disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1289",
          "EFO:0005772",
          "ICD9:349.89",
          "MEDGEN:17999",
          "MESH:D019636",
          "NCIT:C4802",
          "SCTID:80690008",
          "UMLS:C0027746"
        ],
        "synonyms": [
          "degenerative disease",
          "brain degeneration",
          "central nervous system degenerative disorder",
          "central nervous system neurodegenerative disorder",
          "degenerative disorder of central nervous system",
          "cerebral degeneration disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005559"
    },
    {
      "id": 20409,
      "label": "proteostasis deficiencies",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6795,
        29384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:403490",
          "MESH:D057165",
          "UMLS:C2718000"
        ],
        "synonyms": [
          "Proteostasis deficiency",
          "Proteostasis dysfunction",
          "Proteostasis dysfunctions",
          "deficiencies, Proteostasis",
          "deficiency, Proteostasis",
          "dysfunction, Proteostasis",
          "dysfunctions, Proteostasis",
          "Misfolding disease, Protein",
          "Misfolding diseases, Protein",
          "Misfolding disorder, Protein",
          "Misfolding disorders, Protein",
          "Protein Misfolding disease",
          "Protein Misfolding diseases",
          "Protein Misfolding disorder",
          "Protein Misfolding disorders",
          "Protein folding disease",
          "Protein folding diseases",
          "Protein folding disorder",
          "Protein folding disorders",
          "disease, Protein Misfolding",
          "disease, Protein folding",
          "diseases, Protein Misfolding",
          "diseases, Protein folding",
          "disorder, Protein Misfolding",
          "disorder, Protein folding",
          "disorders, Protein Misfolding",
          "disorders, Protein folding",
          "folding disease, Protein",
          "folding diseases, Protein",
          "folding disorder, Protein",
          "folding disorders, Protein",
          "proteinopathy",
          "proteopathic disease",
          "proteopathy"
        ],
        "definition": "Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021179"
    }
  ],
  "children": [
    {
      "id": 8874,
      "label": "Lewy body dementia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2963,
        3823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12217",
          "EFO:0006792",
          "ICD10CM:G31.83",
          "ICD9:331.82",
          "MEDGEN:199874",
          "NCIT:C84826",
          "OMIM:127750",
          "Orphanet:1648",
          "SCTID:312991009",
          "UMLS:C0752347"
        ],
        "synonyms": [
          "DLB",
          "Lewy body dementia",
          "Lewy body disease",
          "cortical Lewy body disease",
          "dementia with Lewy bodies",
          "lewy body dementia, susceptibility to",
          "Lewy body variant of Alzheimer disease",
          "dementia, Lewy body",
          "diffuse Lewy body disease",
          "diffuse Lewy body disease with gaze palsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007488"
    },
    {
      "id": 9146,
      "label": "multiple system atrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2963,
        7073
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4752",
          "EFO:1001050",
          "GARD:0007079",
          "MEDGEN:98276",
          "MESH:D019578",
          "MedDRA:10064060",
          "NANDO:1200034",
          "NCIT:C84909",
          "NORD:1472",
          "Orphanet:102",
          "UMLS:C0393571",
          "icd11.foundation:1890931931"
        ],
        "synonyms": [
          "MSA",
          "Shy-Drager syndrome",
          "multisystem atrophy",
          "Shy-dragger syndrome (formerly)",
          "autonomic failure, Pure",
          "hypotension, orthostatic",
          "susceptibility to multiple system atrophy 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure (cardiovascular and/or urinary), parkinsonism, cerebellar impairment and corticospinal signs with a median survival of 6-9 years."
      },
      "child_count": 8,
      "reference_id": "MONDO:0007803"
    }
  ],
  "roots": [
    {
      "id": 7208,
      "label": "neurodegenerative disease"
    },
    {
      "id": 20409,
      "label": "proteostasis deficiencies"
    }
  ]
}