{
  "id": 2966,
  "label": "bone chondrosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000515",
  "properties": {
    "xrefs": [
      "DOID:0050897",
      "GARD:0022784",
      "MEDGEN:756255",
      "UMLS:C3163843"
    ],
    "synonyms": [
      "bone tissue chondrosarcoma (disease)",
      "chondrosarcoma (disease) of bone tissue"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A chondrosarcoma (disease) that involves the bone tissue."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4262,
      "label": "bone cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3041,
        18958
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2019-1041",
          "DOID:184",
          "EFO:1000350",
          "GARD:0023070",
          "ICD9:170.9",
          "MEDGEN:79002",
          "MESH:D001859",
          "NCIT:C4016",
          "SCTID:428281000",
          "UMLS:C0279530"
        ],
        "synonyms": [
          "bone neoplasm",
          "bone tumor",
          "bone tumour",
          "osseous tumor",
          "osseous tumour",
          "bone cancer",
          "cancer of bone",
          "cancer of skeletal element",
          "cancer of the bone",
          "malignant bone neoplasm",
          "malignant bone tumor",
          "malignant neoplasm of bone",
          "malignant neoplasm of skeletal element",
          "malignant neoplasm of the bone",
          "malignant osseous neoplasm",
          "malignant osseous tumor",
          "malignant osseous tumour",
          "malignant skeletal element neoplasm",
          "malignant tumor of bone",
          "malignant tumor of the bone",
          "malignant tumour of bone",
          "malignant tumour of the bone",
          "osseous cancer",
          "skeletal element cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the bone or articular cartilage."
      },
      "child_count": 24,
      "reference_id": "MONDO:0002129"
    },
    {
      "id": 10235,
      "label": "chondrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        20678,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3371",
          "EFO:0000333",
          "GARD:0006055",
          "HP:0006765",
          "ICD9:170.9",
          "ICDO:9220/3",
          "MEDGEN:3054",
          "MESH:D002813",
          "MedDRA:10008734",
          "NANDO:2200050",
          "NCIT:C2946",
          "OMIM:215300",
          "ONCOTREE:CHS",
          "Orphanet:55880",
          "SCTID:443520009",
          "UMLS:C0008479"
        ],
        "synonyms": [
          "chondrosarcoma",
          "chondrosarcoma (disease)",
          "chondrosarcoma, malignant",
          "chondrosarcoma, somatic mutation",
          "chondrosarcoma of bone",
          "primary chondrosarcoma of the bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion."
      },
      "child_count": 12,
      "reference_id": "MONDO:0008977"
    }
  ],
  "children": [
    {
      "id": 5565,
      "label": "periosteal chondrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2966,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5859",
          "DOID:5866",
          "GARD:0023614",
          "ICDO:9221/3",
          "MEDGEN:90806",
          "NCIT:C7357",
          "UMLS:C0334549"
        ],
        "synonyms": [
          "chondrosarcoma (disease) of periosteum",
          "juxtacortical chondrosarcoma",
          "juxtacortical chondrosarcoma (morphologic abnormality)",
          "periosteal chondrosarcoma",
          "periosteum chondrosarcoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A chondrosarcoma arising from the surface of bone. It is characterized by a lobulated growth pattern, high mitotic activity, myxoid stroma formation, and necrotic changes. It occurs in adults. Clinical presentation includes pain, and sometimes swelling."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003680"
    },
    {
      "id": 5568,
      "label": "clear cell chondrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2966,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5867",
          "GARD:0023617",
          "ICDO:9242/3",
          "MEDGEN:226848",
          "NCIT:C6475",
          "UMLS:C1266167"
        ],
        "synonyms": [
          "clear cell chondrosarcoma",
          "clear cell chondrosarcoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare, usually low grade chondrosarcoma characterized by the presence of tumor cells with clear cytoplasm. It usually arises in the epiphyseal ends of long bones."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003684"
    },
    {
      "id": 6751,
      "label": "dedifferentiated chondrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2966,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081247",
          "EFO:0000394",
          "GARD:0024142",
          "ICDO:9243/3",
          "MEDGEN:209021",
          "NCIT:C6476",
          "ONCOTREE:DDCHS",
          "UMLS:C0862878"
        ],
        "synonyms": [
          "Dedifferentiated chondrosarcoma",
          "DDCHS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An aggressive morphologic variant of chondrosarcoma. It is composed of a low grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. Due to the aggressive nature of the disease, its prognosis is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005013"
    }
  ],
  "roots": [
    {
      "id": 4262,
      "label": "bone cancer"
    },
    {
      "id": 10235,
      "label": "chondrosarcoma"
    }
  ]
}