{ "id": 2972, "label": "salivary gland carcinoma", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0000521", "properties": { "xrefs": [ "DOID:0050904", "GARD:0027535", "MEDGEN:215302", "NANDO:2200076", "NCIT:C9272", "ONCOTREE:SACA", "UMLS:C0948750" ], "synonyms": [ "salivary gland cancer", "carcinoma of saliva-secreting gland", "carcinoma of salivary gland", "carcinoma of the salivary gland", "saliva-secreting gland carcinoma", "salivary gland carcinoma", "salivary carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma that arises from the major or minor salivary glands. Representative examples include carcinoma ex pleomorphic adenoma, adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma." }, "isLeaf": false, "isRoot": false, "child_count": 13, "parents": [ { "id": 6453, "label": "salivary gland cancer", "isLeaf": false, "isRoot": false, "parents": [ 7170, 7266, 20523 ], "type_id": 0, "properties": { "xrefs": [ "DOID:8850", "GARD:0027698", "ICD10CM:C08", "ICD9:142.8", "MEDGEN:65079", "MESH:D012468", "NCIT:C3811", "SCTID:255072001", "UMLS:C0220636" ], "synonyms": [ "cancer of saliva-secreting gland", "cancer of salivary gland", "cancer of the salivary gland", "malignant neoplasm of saliva-secreting gland", "malignant neoplasm of salivary gland", "malignant neoplasm of salivary gland duct", "malignant neoplasm of the salivary gland", "malignant saliva-secreting gland neoplasm", "malignant salivary gland neoplasm", "malignant salivary gland tumor", "malignant salivary gland tumour", "malignant tumor of salivary gland", "malignant tumor of the salivary gland", "malignant tumour of salivary gland", "malignant tumour of the salivary gland", "saliva-secreting gland cancer", "salivary gland cancer", "malignant neoplasm of major salivary gland", "malignant tumour of the major salivary gland" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A primary or metastatic malignant neoplasm that affects the major or minor salivary glands. Representative examples include carcinoma, lymphoma, and sarcoma." }, "child_count": 9, "reference_id": "MONDO:0004669" }, { "id": 23483, "label": "oral cavity carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 7170, 7738, 21254 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0027982", "MEDGEN:57468", "NCIT:C8990", "UMLS:C0151546" ], "synonyms": [ "oral cavity cancer", "carcinoma of mouth", "carcinoma of oral cavity", "carcinoma of the oral cavity", "mouth carcinoma", "oral cavity carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma." }, "child_count": 27, "reference_id": "MONDO:0044925" } ], "children": [ { "id": 5139, "label": "salivary gland adenoid cystic carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 2972, 6713 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4866", "GARD:0023398", "MEDGEN:79034", "NCIT:C8026", "SCTID:422833009", "UMLS:C0279751" ], "synonyms": [ "adenoid cystic cancer", "adenoid cystic carcinoma (morphologic abnormality)", "adenoid cystic carcinoma of salivary gland", "adenoid cystic carcinoma of the salivary gland", "cylindroma (morphologic abnormality)", "saliva-secreting gland adenoid cystic carcinoma", "salivary gland adenoid cystic cancer", "salivary gland adenoid cystic carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "An adenoid cystic carcinoma arising from the salivary gland. It is characterized by the presence of epithelial and myoepithelial cells forming tubular, cribriform, and solid patterns. It usually presents as a slow growing mass. Patients may experience pain because of the tumor propensity for perineural invasion. The tumor may follow an aggressive clinical course with recurrences and mestastases to distant sites including lungs, bones, brain, and liver." }, "child_count": 4, "reference_id": "MONDO:0003175" }, { "id": 7827, "label": "major salivary gland carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 2972, 23418 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000344", "GARD:0027745", "MEDGEN:235287", "NCIT:C5907", "UMLS:C1334549" ], "synonyms": [ "major salivary gland cancer", "carcinoma of Major salivary gland", "carcinoma of major salivary gland", "carcinoma of the major salivary gland", "major salivary gland carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma that arises from the parotid gland, submandibular gland, or sublingual gland." }, "child_count": 12, "reference_id": "MONDO:0006284" }, { "id": 7921, "label": "salivary gland basal cell adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2972, 6712, 7027 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000515", "GARD:0024399", "ICDO:8147/3", "MEDGEN:412203", "NCIT:C3678", "UMLS:C2243086" ], "synonyms": [ "basal cell adenocarcinoma", "basal cell adenocarcinoma of salivary gland", "basal cell adenocarcinoma of the salivary gland", "saliva-secreting gland skin basal cell carcinoma", "salivary gland basal cell adenocarcinoma", "skin basal cell carcinoma of saliva-secreting gland" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A rare adenocarcinoma of the major and minor salivary glands, originating from basaloid, myoepithelial and ductal cells. While morphologically resembling basal cell carcinomas, it is a distinct entity. The tumor is not encapsulated, may invade locally, and less frequently may metastasize. It usually occurs in older patients." }, "child_count": 0, "reference_id": "MONDO:0006402" }, { "id": 7922, "label": "salivary gland carcinoma ex pleomorphic adenoma", "isLeaf": false, "isRoot": false, "parents": [ 2972, 4552 ], "type_id": 0, "properties": { "xrefs": [ "DOID:297", "EFO:1000516", "GARD:0027752", "MEDGEN:274190", "NCIT:C40410", "UMLS:C1519172" ], "synonyms": [ "saliva-secreting gland carcinoma ex pleomorphic adenoma", "salivary gland carcinoma ex pleomorphic adenoma", "pleomorphic adenoma carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma that arises from a pleomorphic adenoma in the salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive." }, "child_count": 2, "reference_id": "MONDO:0006403" }, { "id": 7923, "label": "salivary gland large cell carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2972, 6943, 7257 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000517", "GARD:0027753", "MEDGEN:810975", "NCIT:C35735", "UMLS:C2111671" ], "synonyms": [ "large cell salivary gland carcinoma", "large cell undifferentiated salivary gland carcinoma", "saliva-secreting gland large cell carcinoma", "salivary gland large cell carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A rare, highly aggressive carcinoma that arises from the salivary gland, predominantly the parotid gland. It is characterized by the presence of large pleomorphic malignant cells with abundant cytoplasm. Patients usually present with a rapidly growing mass." }, "child_count": 0, "reference_id": "MONDO:0006404" }, { "id": 7924, "label": "salivary gland small cell carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2894, 2972, 21456 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000519", "GARD:0024400", "MEDGEN:234786", "NCIT:C35703", "UMLS:C1335982" ], "synonyms": [ "anaplastic small cell carcinoma of salivary gland", "anaplastic small cell carcinoma of the salivary gland", "neuroendocrine carcinoma of salivary gland", "neuroendocrine carcinoma of the salivary gland", "saliva-secreting gland small cell carcinoma", "salivary gland anaplastic small cell carcinoma", "salivary gland small cell carcinoma", "small cell carcinoma of saliva-secreting gland", "small cell salivary gland carcinoma", "salivary gland neuroendocrine carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "An infrequent small cell carcinoma that arises from the salivary glands and is characterized by the presence of a high number of mitotic figures." }, "child_count": 0, "reference_id": "MONDO:0006405" }, { "id": 20102, "label": "salivary gland epithelial myoepithelial carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2972, 5321 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0027873", "MEDGEN:234769", "NCIT:C35701", "UMLS:C1335900" ], "synonyms": [ "salivary gland epithelial myoepithelial carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma that arises from the salivary glands, most often the parotid gland. It presents as a slow growing and painless mass. It is characterized by the presence of duct-like structures lined by two layers of cells, an inner layer composed of epithelial-type cells and an outer layer composed of clear, myoepithelial-type cells." }, "child_count": 0, "reference_id": "MONDO:0020694" }, { "id": 20263, "label": "salivary gland mucoepidermoid carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 2972, 23487 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0081293", "GARD:0025273", "MEDGEN:277630", "NCIT:C5908", "SCTID:423708008", "UMLS:C1335903" ], "synonyms": [ "mucoepidermoid carcinoma of salivary gland", "mucoepidermoid carcinoma of the salivary gland", "saliva-secreting gland mucoepidermoid carcinoma", "salivary gland mucoepidermoid carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma that arises from the salivary glands. It is the most common primary carcinoma of the salivary glands and usually presents as a firm and painless mass. It is characterized by the presence of epidermoid cells, mucus producing cells, and cells of intermediate type. The majority of cases have a favorable outcome." }, "child_count": 2, "reference_id": "MONDO:0021009" }, { "id": 23416, "label": "salivary gland squamous cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 2972, 6701, 17510 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1001967", "GARD:0017929", "MEDGEN:83545", "NCIT:C7991", "Orphanet:500481", "UMLS:C0279697" ], "synonyms": [ "SCC of salivary gland", "SCC of the salivary gland", "epidermoid carcinoma of salivary gland", "epidermoid carcinoma of the salivary gland", "saliva-secreting gland squamous cell carcinoma", "salivary gland SCC", "salivary gland epidermoid carcinoma", "salivary gland squamous cell cancer", "salivary gland squamous cell carcinoma", "squamous cell carcinoma of salivary gland", "squamous cell carcinoma of the salivary gland", "squamous cell carcinoma of salivary glands" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" }, { "ref": "MONDO:0024623", "name": "otorhinolaryngologic disease" } ], "definition": "A squamous cell carcinoma arising from the salivary glands. The majority of patients are in their sixth through eight decades. It usually presents as a rapidly enlarging mass, which may be painful. It usually has an aggressive clinical course." }, "child_count": 6, "reference_id": "MONDO:0044740" }, { "id": 23477, "label": "salivary duct carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2972, 7734 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0027981", "MEDGEN:220969", "NCIT:C5904", "ONCOTREE:SDCA", "UMLS:C1301194" ], "synonyms": [ "carcinoma of duct of salivary gland", "carcinoma of salivary duct", "carcinoma of the salivary duct", "duct of salivary gland carcinoma", "high grade salivary duct carcinoma", "salivary duct carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites." }, "child_count": 0, "reference_id": "MONDO:0044915" }, { "id": 23549, "label": "minor salivary gland carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 2972, 20497 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0027985", "MEDGEN:233710", "NCIT:C5957", "UMLS:C1334771" ], "synonyms": [ "carcinoma of minor salivary gland", "carcinoma of the minor salivary gland", "minor salivary gland cancer", "minor salivary gland carcinoma" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A carcinoma that arises from the minor salivary glands. Representative examples include adenoid cystic carcinoma, acinic cell carcinoma, polymorphous low grade adenocarcinoma, and mucinous adenocarcinoma." }, "child_count": 2, "reference_id": "MONDO:0045069" }, { "id": 25185, "label": "salivary gland mucinous adenocarcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2972, 6700 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080800", "GARD:0028070", "MEDGEN:364330", "NCIT:C62193", "UMLS:C1882973" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A salivary gland carcinoma that is characterized by the presence of large pools of extracellular mucin in which clusters of malignant epithelial cells are found." }, "child_count": 0, "reference_id": "MONDO:0850273" }, { "id": 25186, "label": "mammary analog secretory carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 2972 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080808", "GARD:0028071", "MEDGEN:875770", "NCIT:C123384", "UMLS:C4042906" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0006858", "name": "mouth disorder" } ], "definition": "A salivary gland carcinoma that has material basis in a chromosomal translocation that results in an ETV6-NTRK3 fusion gene." }, "child_count": 0, "reference_id": "MONDO:0850281" } ], "roots": [ { "id": 6453, "label": "salivary gland cancer" }, { "id": 23483, "label": "oral cavity carcinoma" } ] }