{
  "id": 2996,
  "label": "autoimmune disorder of central nervous system",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000568",
  "properties": {
    "xrefs": [
      "DOID:0060004",
      "EFO:0020092"
    ],
    "synonyms": [
      "central nervous system autoimmune disease",
      "central nervous system hypersensitivity reaction type II disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A hypersensitivity reaction type II disease that involves the central nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4657,
      "label": "central nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:331",
          "EFO:0009386",
          "MEDGEN:892343",
          "MESH:D002493",
          "NCIT:C2934",
          "SCTID:23853001",
          "UMLS:C4021765"
        ],
        "synonyms": [
          "CNS disorder",
          "central nervous disease",
          "central nervous system disease",
          "central nervous system disease or disorder",
          "central nervous system disorder",
          "disease of central nervous system",
          "disease of the central nervous system",
          "disease or disorder of central nervous system",
          "disorder of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the central nervous system."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002602"
    },
    {
      "id": 4981,
      "label": "autoimmune disorder of the nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:438",
          "MEDGEN:155946",
          "MESH:D020274",
          "NCIT:C99383",
          "UMLS:C0751871"
        ],
        "synonyms": [
          "autoimmune disease of nervous system",
          "autoimmune disease, neurologic",
          "autoimmune diseases, nervous system",
          "autoimmune diseases, neurologic",
          "autoimmune disorders of the nervous system",
          "autoimmune disorders, nervous system",
          "autoimmune nervous system diseases",
          "autoimmune nervous system disorder",
          "disease, neurologic autoimmune",
          "diseases, neurologic autoimmune",
          "immune diseases, nervous system",
          "immune disorders, nervous system",
          "nervous system autoimmune disease",
          "nervous system autoimmune diseases",
          "nervous system hypersensitivity reaction type II disease",
          "nervous system immune diseases",
          "nervous system immune disorders",
          "neurologic autoimmune disease",
          "neurologic autoimmune diseases"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder characterized by the degeneration of the nervous system due to autoimmunity. Representative examples include multiple sclerosis, Guillain-Barre syndrome, and myasthenia gravis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002977"
    }
  ],
  "children": [
    {
      "id": 6995,
      "label": "multiple sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        7209,
        8166,
        20199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2377",
          "ICD10CM:G35",
          "ICD10WHO:G35",
          "ICD9:340",
          "MEDGEN:10123",
          "MESH:D009103",
          "NANDO:1200023",
          "NANDO:2100250",
          "NANDO:2200904",
          "NCIT:C3243",
          "Orphanet:802",
          "SCTID:24700007",
          "UMLS:C0026769",
          "icd11.foundation:1298865187"
        ],
        "synonyms": [
          "generalised multiple sclerosis",
          "generalized multiple sclerosis",
          "insular sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005301"
    },
    {
      "id": 7462,
      "label": "Miller Fisher syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2996,
        4370,
        4515
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12889",
          "EFO:0007371",
          "GARD:0003668",
          "MEDGEN:95994",
          "MESH:D019846",
          "MedDRA:10049567",
          "NCIT:C116958",
          "Orphanet:98919",
          "SCTID:1767005",
          "UMLS:C0393799",
          "icd11.foundation:134795253"
        ],
        "synonyms": [
          "Fisher syndrome",
          "Guillain Barre syndrome, Miller Fisher variant",
          "Guillain-Barre syndrome, Miller Fisher variant",
          "Miller Fisher variant of Guillain Barre syndrome",
          "Miller-Fisher syndrome",
          "cranial variant of GBS",
          "cranial variant of Guillain-Barre syndrome",
          "cranial variant of Guillain-Barré syndrome",
          "ophthalmoplegia, ataxia and areflexia syndrome",
          "syndrome, Fisher",
          "syndrome, Miller Fisher",
          "syndrome, Miller-Fisher"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An autoimmune process characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005851"
    },
    {
      "id": 18526,
      "label": "autoimmune encephalopathy with parasomnia and obstructive sleep apnea",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2996,
        5338,
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021749",
          "MEDGEN:1644256",
          "Orphanet:420789",
          "SCTID:765751002",
          "UMLS:C4707562"
        ],
        "synonyms": [
          "anti-IgLON5 disease",
          "anti-IgLON5 syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Autoimmune encephalopathy with parasomnia and obstructive sleep apnea is a rare neurologic disorder characterized by a unique non-REM and REM parasomnia with sleep breathing dysfunction, gait instability and repetitive episodes of respiratory insufficiency, as well as autoantibodies against IgLON5. Patients may present stridor, chorea, limb ataxia, abnormal ocular movements, and bulbar symptoms (i.e. dysphagia, dysarthria, episodic central hypoventilation) with normal brain MRI. Excessive day sleepiness and cognitive deterioration have also been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018489"
    },
    {
      "id": 19568,
      "label": "primary hypophysitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        2997,
        19567,
        20389
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019281",
          "ICD9:253.8",
          "ICD9:279.49",
          "MEDGEN:575013",
          "MESH:D000069281",
          "NCIT:C132055",
          "Orphanet:95506",
          "SCTID:237706000",
          "UMLS:C0342410"
        ],
        "synonyms": [
          "autoimmune hypophysitis",
          "lymphocytic hypophysitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Immune-mediated inflammation of the pituitary gland often associated with other autoimmune diseases (e.g., hashimoto disease; graves disease; and addison disease)."
      },
      "child_count": 12,
      "reference_id": "MONDO:0019835"
    },
    {
      "id": 20055,
      "label": "autoimmune encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        19673
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011979",
          "MEDGEN:1804547",
          "NANDO:2100248",
          "NANDO:2200902",
          "NCIT:C122414",
          "Orphanet:622014",
          "SCTID:95643007",
          "UMLS:C5671289",
          "icd11.foundation:241281019"
        ],
        "synonyms": [
          "autoimmune encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation of the brain secondary to an immune response triggered by the body itself."
      },
      "child_count": 4,
      "reference_id": "MONDO:0020640"
    },
    {
      "id": 22197,
      "label": "autoimmune optic neuritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2996,
        3006,
        7490
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0040089",
          "GARD:0027934"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "An autoimmune form of optic neuritis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0031013"
    },
    {
      "id": 23269,
      "label": "central nervous system lupus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2996,
        9248,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025875",
          "MEDGEN:156265",
          "MESH:D020945",
          "NCIT:C116919",
          "UMLS:C0752332"
        ],
        "synonyms": [
          "CNS lupus",
          "central nervous system lupus",
          "Meningoencephalitides, lupus",
          "central nervous system lupus vasculitis",
          "central nervous system systemic lupus Erythematosis",
          "lupus Meningoencephalitides",
          "lupus meningoencephalitis",
          "meningoencephalitis, lupus",
          "neuropsychiatric systemic lupus erythematosus",
          "systemic lupus Erythematosis, central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Inflammation that includes the brain, spinal cord and surrounding tissues secondary to systemic lupus erythematosus (SLE); it is associated with neurological and/or psychiatric features."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043985"
    },
    {
      "id": 25217,
      "label": "autoimmune epilepsy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2996,
        23785
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080994"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An epilepsy that is characterized by new-onset refractory seizures along with subacute progressive cognitive decline and behavioral or psychiatric dysfunction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850416"
    }
  ],
  "roots": [
    {
      "id": 4657,
      "label": "central nervous system disorder"
    },
    {
      "id": 4981,
      "label": "autoimmune disorder of the nervous system"
    }
  ]
}