{
  "id": 3002,
  "label": "autoimmune disorder of exocrine system",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000586",
  "properties": {
    "xrefs": [
      "DOID:0060029"
    ],
    "synonyms": [
      "exocrine system autoimmune disease",
      "exocrine system hypersensitivity reaction type II disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A hypersensitivity reaction type II disease that involves the exocrine system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 3797,
      "label": "benign lymphoepithelial lesion of salivary gland",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3002,
        3387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12899",
          "ICD9:527.8",
          "MEDGEN:120595",
          "NCIT:C3949",
          "SCTID:45517002",
          "UMLS:C0266995",
          "icd11.foundation:1330363110"
        ],
        "synonyms": [
          "Godwin tumor",
          "Godwin tumour",
          "benign lymphoepithelial lesion of salivary gland",
          "benign lymphoepithelial lesion of the salivary gland",
          "benign salivary gland lymphoepithelial lesion"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A benign lesion that involves the salivary glands, usually the parotid gland. It affects females more often than males and it may be a manifestation of autoimmune diseases such as Sjogren syndrome. There is an increased incidence of benign lymphoepithelial lesions in HIV-positive patients. It is characterized by the presence of a marked lymphocytic infiltrate and epi-myoepithelial islands in the affected salivary gland. Patients usually present with firm and painless swelling of the affected salivary gland. There is an increased risk for development of lymphoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001598"
    },
    {
      "id": 11224,
      "label": "Sjogren syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3002,
        3387,
        4370,
        21539
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12894",
          "EFO:0000699",
          "ICD10CM:M35.0",
          "ICD9:710.2",
          "MEDGEN:282890",
          "MESH:D012859",
          "NANDO:1200279",
          "NANDO:1200280",
          "NANDO:2200420",
          "NCIT:C26883",
          "OMIM:270150",
          "Orphanet:289390",
          "Orphanet:378",
          "SCTID:83901003",
          "UMLS:C1527336",
          "icd11.foundation:899463360"
        ],
        "synonyms": [
          "Sjogren syndrome",
          "Sjögren syndrome",
          "Sjögren-Gougerot syndrome",
          "primary Sjogren-Gougerot syndrome",
          "primary Sjögren-Gougerot syndrome",
          "sicca syndrome",
          "syndrome, Sjogren's",
          "Sjogren's syndrome",
          "primary Sjögren syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "An autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain"
      },
      "child_count": 0,
      "reference_id": "MONDO:0010030"
    },
    {
      "id": 16828,
      "label": "autoimmune hepatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2997,
        3002,
        3004,
        4367
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2048",
          "EFO:0005676",
          "GARD:0005871",
          "ICD10CM:K75.4",
          "ICD9:571.42",
          "MEDGEN:1666753",
          "MESH:D019693",
          "MedDRA:10003827",
          "NANDO:1200441",
          "NANDO:1200442",
          "NANDO:2100264",
          "NCIT:C27029",
          "NORD:1897",
          "Orphanet:2137",
          "SCTID:408335007",
          "UMLS:C4721555",
          "icd11.foundation:1235727122"
        ],
        "synonyms": [
          "autoimmune liver disease",
          "autoimmune hepatitis",
          "autoimmune chronic active hepatitis",
          "autoimmune hepatitis with centrilobular necrosis",
          "chronic autoimmune hepatitis",
          "AIH",
          "autoimmune chronic hepatitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hepatitis caused by autoantibodies. Drugs, infections, and toxins may trigger the production of the autoantibodies against the liver parenchyma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0016264"
    }
  ],
  "roots": [
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}