{
  "id": 3004,
  "label": "autoimmune disorder of gastrointestinal tract",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000588",
  "properties": {
    "xrefs": [
      "DOID:0060031"
    ],
    "synonyms": [
      "alimentary part of gastrointestinal system autoimmune disease",
      "alimentary part of gastrointestinal system hypersensitivity reaction type II disease",
      "autoimmune disease of alimentary part of gastrointestinal system"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A hypersensitivity reaction type II disease that involves the alimentary part of gastrointestinal system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6151,
      "label": "digestive system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:77",
          "ICD10CM:K00-K95",
          "ICD9:520-579",
          "ICD9:V47.3",
          "MEDGEN:892790",
          "MESH:D005767",
          "NANDO:1100013",
          "NCIT:C2990",
          "SCTID:53619000",
          "UMLS:C4023588",
          "icd11.foundation:1256772020"
        ],
        "synonyms": [
          "digestive disease",
          "digestive system disease",
          "digestive system disease or disorder",
          "digestive system disorder",
          "disease of digestive system",
          "disease or disorder of digestive system",
          "disorder of digestive system",
          "gastroenterological system disease",
          "gastroenterological system disorder",
          "gastrointestinal disorder",
          "gastrointestinal system disease",
          "gastrointestinal system disorder",
          "stomach or intestinal disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the digestive system."
      },
      "child_count": 31,
      "reference_id": "MONDO:0004335"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [
    {
      "id": 6854,
      "label": "celiac disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3004,
        5714,
        20033,
        21546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10608",
          "EFO:0001060",
          "ICD10CM:K90.0",
          "ICD9:579.0",
          "MEDGEN:3291",
          "MESH:D002446",
          "NCIT:C26714",
          "OMIMPS:212750",
          "Orphanet:555",
          "SCTID:396331005",
          "UMLS:C0007570",
          "icd11.foundation:2005943638"
        ],
        "synonyms": [
          "celiac disease",
          "celiac sprue",
          "coeliac sprue",
          "gluten intolerance",
          "gluten-induced enteropathy",
          "non tropical sprue"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005130"
    },
    {
      "id": 6871,
      "label": "type 1 diabetes mellitus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2997,
        3004,
        6752
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9744",
          "ICD10CM:E10",
          "ICD10WHO:E10",
          "MEDGEN:41522",
          "MESH:D003922",
          "NANDO:2200460",
          "NCIT:C2986",
          "OMIM:222100",
          "Orphanet:243377",
          "SCTID:46635009",
          "UMLS:C0011854",
          "icd11.foundation:1651053999"
        ],
        "synonyms": [
          "IDDM",
          "T1D",
          "T1DM",
          "diabetes mellitis type 1",
          "diabetes mellitis type I",
          "immune mediated diabetes",
          "insulin dependent diabetes",
          "juvenile diabetes",
          "type 1 diabetes",
          "type I diabetes",
          "type I diabetes mellitus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A chronic condition characterized by minimal or absent production of insulin by the pancreas."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005147"
    },
    {
      "id": 16099,
      "label": "autoimmune pancreatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2997,
        3004,
        6723,
        17611
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0040091",
          "GARD:0010911",
          "MEDGEN:750633",
          "MESH:D000081012",
          "MedDRA:10069002",
          "NANDO:1200925",
          "NANDO:2200943",
          "Orphanet:103919",
          "SCTID:448542008",
          "UMLS:C2609129",
          "icd11.foundation:2057951941"
        ],
        "synonyms": [
          "AIP",
          "lymphoplasmocytic sclerosing pancreatitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Autoimmune pancreatitis (AIP) is a rare pancreatic disease characterized by chronic non-alcoholic pancreatitis that presents with abdominal pain, steatorrhea, obstructive jaundice and responds well to steroid therapy and is seen in two subforms: type 1 AIP which affects elderly males, involves other organs and has increased immunoglobin G4 (IgG4) levels and type 2 AIP which affects both sexes equally but presents at a younger age and has no other organ involvement or increased IgG4 levels."
      },
      "child_count": 8,
      "reference_id": "MONDO:0015175"
    },
    {
      "id": 16828,
      "label": "autoimmune hepatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2997,
        3002,
        3004,
        4367
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2048",
          "EFO:0005676",
          "GARD:0005871",
          "ICD10CM:K75.4",
          "ICD9:571.42",
          "MEDGEN:1666753",
          "MESH:D019693",
          "MedDRA:10003827",
          "NANDO:1200441",
          "NANDO:1200442",
          "NANDO:2100264",
          "NCIT:C27029",
          "NORD:1897",
          "Orphanet:2137",
          "SCTID:408335007",
          "UMLS:C4721555",
          "icd11.foundation:1235727122"
        ],
        "synonyms": [
          "autoimmune liver disease",
          "autoimmune hepatitis",
          "autoimmune chronic active hepatitis",
          "autoimmune hepatitis with centrilobular necrosis",
          "chronic autoimmune hepatitis",
          "AIH",
          "autoimmune chronic hepatitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hepatitis caused by autoantibodies. Drugs, infections, and toxins may trigger the production of the autoantibodies against the liver parenchyma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0016264"
    },
    {
      "id": 18641,
      "label": "IgG4-related sclerosing cholangitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2997,
        3004,
        17611,
        18642
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021867",
          "MEDGEN:927778",
          "NANDO:1200928",
          "Orphanet:447764",
          "SCTID:722870008",
          "UMLS:C4302109",
          "icd11.foundation:1676971795"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018645"
    },
    {
      "id": 19530,
      "label": "autoimmune enteropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3004,
        20033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008689",
          "ICD9:279.49",
          "MEDGEN:83322",
          "MESH:C538273",
          "NANDO:2200923",
          "NCIT:C94694",
          "Orphanet:94075",
          "SCTID:235728001",
          "UMLS:C0341305"
        ],
        "synonyms": [
          "immune-mediated protracted diarrhea of infancy",
          "immune-mediated protracted diarrhoea of infancy",
          "severe immune-mediated enteropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Severe-immune mediated enteropathy describes a variety of intestinal disorders that can range from a serious, early-onset systemic disease (IPEX) to a mild isolated gastrointestinal disease. In children it manifests with severe diarrhea and dehydration in the presence of characteristic antibodies (anti-enterocyte and anti-goblet cell) and in adults with chronic diarrhea, malabsorption and weight loss."
      },
      "child_count": 8,
      "reference_id": "MONDO:0019787"
    },
    {
      "id": 22198,
      "label": "autoimmune gastritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3004,
        6709
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0040090",
          "MEDGEN:854482",
          "NCIT:C95752",
          "UMLS:C3887639",
          "icd11.foundation:248006617"
        ],
        "synonyms": [
          "autoimmune gastritis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Inflammation of the body fundic mucosa of the stomach. It results from the development of autoantibodies against the parietal and chief cells. It is associated with the presence of intestinal metaplasia and an increased risk of developing gastric carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0031014"
    }
  ],
  "roots": [
    {
      "id": 6151,
      "label": "digestive system disorder"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}