{
  "id": 3007,
  "label": "intrinsic cardiomyopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000591",
  "properties": {
    "xrefs": [
      "DOID:0060036",
      "GARD:0022809"
    ],
    "synonyms": [
      "intrinsic cardiomyopathy",
      "primary cardiomyopathy"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A cardiomyopathy that is due to abnormalities in heart muscle cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 6735,
      "label": "cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5798,
        6967
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050700",
          "EFO:0000318",
          "ICD10CM:I42",
          "ICD10WHO:I42",
          "ICD9:425",
          "ICD9:425.4",
          "ICD9:425.9",
          "MEDGEN:209232",
          "MESH:D009202",
          "MedDRA:10007636",
          "NCIT:C34830",
          "Orphanet:167848",
          "SCTID:85898001",
          "UMLS:C0878544",
          "icd11.foundation:282225286"
        ],
        "synonyms": [
          "Cardiomyopathies",
          "cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive."
      },
      "child_count": 24,
      "reference_id": "MONDO:0004994"
    }
  ],
  "children": [
    {
      "id": 6298,
      "label": "myocarditis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3007,
        21547,
        21552
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:820",
          "EFO:0009609",
          "GARD:0007137",
          "ICD10CM:I40",
          "ICD9:429.0",
          "MEDGEN:44553",
          "MESH:D009205",
          "NCIT:C34831",
          "NORD:1882",
          "SCTID:50920009",
          "UMLS:C0027059",
          "icd11.foundation:1018829714"
        ],
        "synonyms": [
          "inflammation of myocardium",
          "myocardial inflammation (finding)",
          "myocardium inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Myocarditis is a condition that is characterized by inflammation of the heart muscle (myocardium). Some affected people have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. Myocarditis can be caused by a variety of factors including infections (viral, bacterial, parasitic, and fungal), allergic reactions to certain medications, and exposure to certain chemicals. It can also be associated with other inflammatory conditions such as lupus, Wegener's granulomatosis, giant cell arteritis and Takayasu's arteritis. Most cases occur sporadically in people with no family history of the condition. Treatment aims to address the underlying cause of the condition. Medications and rarely, a heart transplant may be needed if the heart muscle becomes weak."
      },
      "child_count": 21,
      "reference_id": "MONDO:0004496"
    },
    {
      "id": 6757,
      "label": "dilated cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3007
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12930",
          "EFO:0000407",
          "GARD:0000221",
          "HP:0001644",
          "ICD10CM:I42.0",
          "ICD9:425.4",
          "MEDGEN:2880",
          "MESH:D002311",
          "MedDRA:10056370",
          "NANDO:2100057",
          "NANDO:2200232",
          "NCIT:C84673",
          "Orphanet:217604",
          "SCTID:195021004",
          "UMLS:C0007193",
          "icd11.foundation:1916294688"
        ],
        "synonyms": [
          "dilated cardiomyopathy",
          "familial dilated cardiomyopathy",
          "idiopathic dilation cardiomyopathy",
          "primary dilated cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. It may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. It is a cause of congestive heart failure."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005021"
    },
    {
      "id": 6777,
      "label": "hypertrophic cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3007
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11984",
          "EFO:0000538",
          "HP:0001639",
          "ICD10CM:I42.1",
          "ICD10CM:I42.2",
          "ICD9:425.1",
          "ICD9:425.11",
          "ICD9:425.4",
          "MEDGEN:2881",
          "MESH:D002312",
          "MedDRA:10020871",
          "NANDO:1200286",
          "NANDO:1200288",
          "NANDO:2100054",
          "NANDO:2200229",
          "NANDO:2201042",
          "NCIT:C34449",
          "Orphanet:217569",
          "SCTID:233873004",
          "UMLS:C0007194",
          "icd11.foundation:1830681485"
        ],
        "synonyms": [
          "hypertrophic cardiomyopathy",
          "hypertrophic subaortic stenosis",
          "obstructive hypertrophic cardiomyopathy",
          "familial hypertrophic cardiomyopathy",
          "HCM - hypertrophic cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005045"
    },
    {
      "id": 6919,
      "label": "restrictive cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3007
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:397",
          "EFO:0002630",
          "GARD:0020531",
          "ICD9:425.4",
          "MEDGEN:40111",
          "MESH:D002313",
          "MedDRA:10038748",
          "NANDO:1200292",
          "NANDO:1200293",
          "NANDO:2100058",
          "NANDO:2200233",
          "NCIT:C62798",
          "Orphanet:217632",
          "SCTID:415295002",
          "UMLS:C0007196",
          "icd11.foundation:316495940"
        ],
        "synonyms": [
          "restrictive cardiomyopathy",
          "familial restrictive cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005201"
    },
    {
      "id": 17077,
      "label": "arrhythmogenic right ventricular cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3007
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050431",
          "GARD:0005847",
          "ICD9:425.4",
          "MEDGEN:87618",
          "MESH:D019571",
          "MedDRA:10058093",
          "NANDO:2100055",
          "NANDO:2200230",
          "NCIT:C84571",
          "Orphanet:247",
          "SCTID:281170005",
          "UMLS:C0349788",
          "icd11.foundation:1931494126"
        ],
        "synonyms": [
          "ARVD",
          "arrhythmogenic RVD",
          "arrhythmogenic right ventricular cardiomyopathy",
          "arrhythmogenic right ventricular dysplasia",
          "right ventricular dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease that consists in progressive dystrophy of primarily the right ventricular myocardium with fibro-fatty replacement and ventricular dilation, and that is clinically characterized by ventricular arrhythmias and a risk of sudden cardiac death."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016587"
    },
    {
      "id": 18829,
      "label": "left ventricular noncompaction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3007,
        6933,
        24336
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060480",
          "GARD:0010985",
          "MEDGEN:450531",
          "NANDO:2200231",
          "NCIT:C99544",
          "OMIMPS:604169",
          "Orphanet:54260",
          "UMLS:C1960469"
        ],
        "synonyms": [
          "LVNC",
          "Lv non-compaction syndrome",
          "left ventricular hypertrabeculation",
          "left ventricular non-compaction cardiomyopathy",
          "left ventricular non-compaction syndrome",
          "left ventricular noncompaction (disease)",
          "spongy myocardium"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Left ventricular noncompaction (LVNC) is a rare cardiomyopathy characterized anatomically by prominent left ventricular trabeculae and deep intratrabecular recesses causing progressive systolic and diastolic dysfunction, conduction abnormalities, and occasionally thromboembolic events."
      },
      "child_count": 39,
      "reference_id": "MONDO:0018901"
    }
  ],
  "roots": [
    {
      "id": 6735,
      "label": "cardiomyopathy"
    }
  ]
}