{
  "id": 3018,
  "label": "hypersensitivity reaction disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000605",
  "properties": {
    "xrefs": [
      "DOID:0060056",
      "EFO:1002003",
      "MEDGEN:759636",
      "NCIT:C3114",
      "SCTID:473010000",
      "UMLS:C3532523"
    ],
    "synonyms": [
      "allergic reaction",
      "sensitive",
      "sensitivity",
      "hypersensitive",
      "hypersensitivity",
      "hypersensitivity reaction"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6778,
      "label": "immune system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2914",
          "EFO:0000540",
          "ICD9:279",
          "ICD9:279.1",
          "ICD9:279.10",
          "ICD9:279.19",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:279.8",
          "ICD9:279.9",
          "MEDGEN:5759",
          "MESH:D007154",
          "NANDO:1100004",
          "NANDO:2100202",
          "NCIT:C3507",
          "SCTID:414029004",
          "UMLS:C0021053"
        ],
        "synonyms": [
          "disease of immune system",
          "disease or disorder of immune system",
          "disorder of immune system",
          "immune disease",
          "immune disorder",
          "immune dysfunction",
          "immune system disease or disorder",
          "immune system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from an abnormality in the immune system."
      },
      "child_count": 47,
      "reference_id": "MONDO:0005046"
    }
  ],
  "children": [
    {
      "id": 4539,
      "label": "type IV hypersensitivity disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2916",
          "MEDGEN:9371",
          "NCIT:C3115",
          "UMLS:C0020522"
        ],
        "synonyms": [
          "DTH",
          "delayed hypersensitivity reaction",
          "delayed-type hypersensitivity",
          "delayed-type hypersensitivity response",
          "disorder of type IV hypersensitivity",
          "type 4 hypersensitivity reaction",
          "type IV hypersensitivity",
          "type IV hypersensitivity reaction",
          "hypersensitivity reaction type IV disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disease that has its basis in the disruption of type IV hypersensitivity."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002459"
    },
    {
      "id": 6969,
      "label": "allergic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1205",
          "ICD9:995.3",
          "ICD9:V15.09",
          "MEDGEN:9370",
          "MESH:D006967",
          "NCIT:C114476",
          "SCTID:609328004",
          "UMLS:C0020517"
        ],
        "synonyms": [
          "allergic disease or disorder",
          "allergic form of disease or disorder",
          "allergic form of immune system disease",
          "allergic reaction",
          "allergic response",
          "allergy",
          "disorder of type I hypersensitivity",
          "type I hypersensitivity disease",
          "allergic hypersensitivity disease",
          "hypersensitivity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005271"
    },
    {
      "id": 8242,
      "label": "hypersensitivity vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018,
        18813
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9809",
          "EFO:1000974",
          "GARD:0024475",
          "ICD9:446.2",
          "ICD9:446.20",
          "ICD9:446.29",
          "MEDGEN:445500",
          "MedDRA:10020764",
          "NCIT:C82863",
          "SCTID:60555002",
          "UMLS:C2973529"
        ],
        "synonyms": [
          "leukocytoclastic vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A small vessel vasculitis affecting the skin and/or internal organs. It is characterized by the presence of neutrophils and fibrinoid necrosis in small arteries and venules. It may be idiopathic or the result of drug treatment, infections, food intake, collagen vascular disorders, inflammatory bowel disease, or cancer."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006794"
    },
    {
      "id": 8426,
      "label": "type III hypersensitivity disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1557",
          "EFO:1001222",
          "MEDGEN:7021",
          "MESH:D007105",
          "MedDRA:10045265",
          "NCIT:C114346",
          "UMLS:C0020951"
        ],
        "synonyms": [
          "disorder of type III hypersensitivity",
          "type 3 hypersensitivity reaction",
          "type III hypersensitivity",
          "type III hypersensitivity reaction",
          "hypersensitivity reaction type III disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa."
      },
      "child_count": 4,
      "reference_id": "MONDO:0007004"
    },
    {
      "id": 9157,
      "label": "IgE responsiveness, atopic",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3018,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:327063",
          "MESH:C564133",
          "NCIT:C3116",
          "OMIM:147050",
          "UMLS:C1840253"
        ],
        "synonyms": [
          "IgE responsiveness, atopic",
          "IgE, elevated level of",
          "immediate hypersensitivity",
          "type 1 hypersensitivity",
          "type 1 hypersensitivity reaction",
          "type I hypersensitivity",
          "type I hypersensitivity reaction",
          "type I immediate hypersensitivity reaction",
          "Atopic hypersensitivity",
          "IGER",
          "IgE response underlying allergic asthma and rhinitis",
          "IgE responsiveness, ATOPIC",
          "IgE, level of",
          "Immunoglobulin E, basic level of, in serum",
          "atopy, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007817"
    },
    {
      "id": 11734,
      "label": "immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2997,
        3018,
        4370,
        5714,
        16071,
        19530
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0090110",
          "GARD:0001850",
          "ICD9:250.81",
          "MEDGEN:83339",
          "MESH:C580192",
          "NANDO:2200924",
          "NCIT:C131009",
          "OMIM:304790",
          "Orphanet:37042",
          "SCTID:237618001",
          "UMLS:C0342288",
          "icd11.foundation:1060287444"
        ],
        "synonyms": [
          "DMSD",
          "IDDM-secretory diarrhea syndrome",
          "IDDM-secretory diarrhoea syndrome",
          "IPEX",
          "X linked polyendocrinopathy",
          "X-linked autoimmunity-allergic dysregulation syndrome",
          "XLAAD",
          "XPID",
          "autoimmune enteropathy type 1",
          "autoimmunity-immunodeficiency syndrome, X-linked",
          "diabetes mellitus, congenital insulin-dependent, with fatal secretory diarrhea",
          "diabetes mellitus, congenital insulin-dependent, with fatal secretory diarrhoea",
          "diarrhea, polyendocrinopathy, fatal infection syndrome, X-linked",
          "immune dysfunction and diarrhea syndrome",
          "immune dysfunction and diarrhoea syndrome",
          "immune dysregulation, polyendocrinopathy, and enteropathy X-linked syndrome",
          "immunodysregulation, polyendocrinopathy, and enteropathy, X-linked",
          "immunodysregulation, polyendocrinopathy, and enteropathy, X-linked, X-linked recessive",
          "IDDM secretory diarrhea syndrome",
          "IDDM secretory diarrhoea syndrome",
          "IMMUNODYSREGULATION, polyendocrinopathy, and enteropathy, X-linked",
          "IPEX syndrome",
          "Iddm-secretory diarrhea syndrome",
          "Iddm-secretory diarrhoea syndrome",
          "Immunodysregulation, polyendocrinopathy and enteropathy X-linked",
          "autoimmunity-immunodeficiency syndrome X-linked",
          "enteropathy, autoimmune, with hemolytic Anaemia and polyendocrinopathy",
          "enteropathy, autoimmune, with hemolytic Anemia and polyendocrinopathy",
          "immunodeficiency, polyendocrinopathy, and enteropathy, X-linked, formerly",
          "islets of Langerhans, absence of",
          "polyendocrinopathy, immune dysfunction and diarrhea X-linked",
          "polyendocrinopathy, immune dysfunction and diarrhoea X-linked",
          "polyendocrinopathy, immune dysfunction, and diarrhea, X-linked"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Immunodysregulation - polyendocrinopathy - enteropathy - X-linked (IPEX) syndrome is a severe congenital systemic autoimmune disease characterized by refractory diarrhea, endocrinopathies, cutaneous involvement, and infections."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010580"
    },
    {
      "id": 20791,
      "label": "progestogen hypersensitivity",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:708.8",
          "MEDGEN:220359",
          "MESH:C535299",
          "SCTID:400009001",
          "UMLS:C1260879"
        ],
        "synonyms": [
          "APD",
          "PH",
          "autoimmune progesterone dermatitis",
          "autoimmune progesterone dermatitis/urticaria",
          "autoimmune progesterone urticaria",
          "progesterone dermatitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Progestogen hypersensitivity (PH), also referred to as autoimmune progesterone dermatitis (APD), is a rare immediate or delayed hypersensitivity reaction to endogenous progesterone and/or synthetic progestins characterized by diverse cutaneous manifestations, bronchospasm, and/or anaphylaxis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021952"
    },
    {
      "id": 21708,
      "label": "type II hypersensitivity reaction disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3018,
        8586
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "disorder of type II hypersensitivity",
          "type II hypersensitivity disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disease that has its basis in the disruption of type II hypersensitivity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0025512"
    },
    {
      "id": 23490,
      "label": "pseudoallergy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:V15.09",
          "MEDGEN:783416",
          "SCTID:609397002",
          "UMLS:C3662262"
        ],
        "synonyms": [
          "non-allergic hypersensitivity to substance",
          "pseudoallergy to substance"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0044981"
    },
    {
      "id": 23805,
      "label": "anaphylaxis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1373755",
          "MESH:D000707",
          "MedDRA:10002198",
          "NCIT:C107101",
          "SCTID:39579001",
          "UMLS:C4316895",
          "icd11.foundation:1868068711"
        ],
        "synonyms": [
          "anaphylactic shock",
          "systemic anaphylaxis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An acute hypersensitivity reaction that occurs from exposure to an allergen. It results from the release of histamine and histamine-like substances from mast cells, and can present with breathing difficulty due to narrowed airways, dizziness and hypotension, skin rash, weak pulse, nausea and vomiting."
      },
      "child_count": 2,
      "reference_id": "MONDO:0100053"
    }
  ],
  "roots": [
    {
      "id": 6778,
      "label": "immune system disorder"
    }
  ]
}