{
  "id": 3028,
  "label": "immune system cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000621",
  "properties": {
    "xrefs": [
      "DOID:0060083"
    ],
    "synonyms": [
      "cancer of immune system",
      "immune system cancer",
      "malignant immune system neoplasm",
      "malignant neoplasm of immune system"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A malignant neoplasm involving the immune system"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 25,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    },
    {
      "id": 6778,
      "label": "immune system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2914",
          "EFO:0000540",
          "ICD9:279",
          "ICD9:279.1",
          "ICD9:279.10",
          "ICD9:279.19",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:279.8",
          "ICD9:279.9",
          "MEDGEN:5759",
          "MESH:D007154",
          "NANDO:1100004",
          "NANDO:2100202",
          "NCIT:C3507",
          "SCTID:414029004",
          "UMLS:C0021053"
        ],
        "synonyms": [
          "disease of immune system",
          "disease or disorder of immune system",
          "disorder of immune system",
          "immune disease",
          "immune disorder",
          "immune dysfunction",
          "immune system disease or disorder",
          "immune system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from an abnormality in the immune system."
      },
      "child_count": 47,
      "reference_id": "MONDO:0005046"
    }
  ],
  "children": [
    {
      "id": 3023,
      "label": "lymphatic system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        7447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060073"
        ],
        "synonyms": [
          "cancer of lymphatic part of lymphoid system",
          "lymphatic part of lymphoid system cancer",
          "malignant lymphatic part of lymphoid system neoplasm",
          "malignant neoplasm of lymphatic part of lymphoid system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the lymphatic part of lymphoid system"
      },
      "child_count": 8,
      "reference_id": "MONDO:0000612"
    },
    {
      "id": 3161,
      "label": "T-cell childhood acute lymphocytic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        3160,
        6212,
        6706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080145",
          "EFO:1001947",
          "GARD:0007346",
          "MEDGEN:75996",
          "NCIT:C7953",
          "UMLS:C0279583"
        ],
        "synonyms": [
          "T acute lymphoblastic leukaemia",
          "T acute lymphoblastic leukemia",
          "T-cell childhood ALL",
          "T-cell childhood acute lymphoblastic leukaemia",
          "T-cell childhood acute lymphoblastic leukemia",
          "T-cell childhood acute lymphocytic leukemia",
          "T-cell paediatric ALL",
          "T-cell paediatric acute lymphoblastic leukaemia",
          "T-cell paediatric acute lymphocytic leukaemia",
          "T-cell pediatric ALL",
          "T-cell pediatric acute lymphoblastic leukemia",
          "T-cell pediatric acute lymphocytic leukemia",
          "childhood T acute lymphoblastic leukaemia",
          "childhood T acute lymphoblastic leukemia",
          "childhood T-ALL",
          "childhood T-cell acute lymphoblastic leukaemia",
          "childhood T-cell acute lymphoblastic leukemia",
          "childhood precursor T-lymphoblastic leukaemia",
          "childhood precursor T-lymphoblastic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute lymphoblastic leukemia of T-cell origin occurring in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000871"
    },
    {
      "id": 3162,
      "label": "B-cell childhood acute lymphoblastic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        3160,
        19962
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080146",
          "EFO:1001946",
          "GARD:0022835",
          "MEDGEN:83526",
          "NANDO:2200002",
          "NCIT:C9140",
          "UMLS:C0279584"
        ],
        "synonyms": [
          "B acute lymphoblastic leukaemia",
          "B acute lymphoblastic leukemia",
          "B cell childhood ALL",
          "B cell childhood acute lymphoblastic leukaemia",
          "B cell childhood acute lymphoblastic leukemia",
          "B cell childhood acute lymphocytic leukaemia",
          "B cell childhood acute lymphocytic leukemia",
          "B cell paediatric ALL",
          "B cell paediatric acute lymphoblastic leukaemia",
          "B cell paediatric acute lymphocytic leukaemia",
          "B cell pediatric ALL",
          "B cell pediatric acute lymphoblastic leukemia",
          "B cell pediatric acute lymphocytic leukemia",
          "B-cell childhood ALL",
          "B-cell childhood acute lymphocytic leukaemia",
          "B-cell childhood acute lymphocytic leukemia",
          "B-cell childhood acute lymphogenous leukaemia",
          "B-cell childhood acute lymphogenous leukemia",
          "B-cell childhood acute lymphoid leukaemia",
          "B-cell childhood acute lymphoid leukemia",
          "B-cell paediatric ALL",
          "B-cell paediatric acute lymphoblastic leukaemia",
          "B-cell paediatric acute lymphocytic leukaemia",
          "B-cell paediatric acute lymphogenous leukaemia",
          "B-cell paediatric acute lymphoid leukaemia",
          "B-cell pediatric ALL",
          "B-cell pediatric acute lymphoblastic leukemia",
          "B-cell pediatric acute lymphocytic leukemia",
          "B-cell pediatric acute lymphogenous leukemia",
          "B-cell pediatric acute lymphoid leukemia",
          "childhood B acute lymphoblastic leukaemia",
          "childhood B acute lymphoblastic leukemia",
          "childhood B-ALL",
          "childhood precursor B-lymphoblastic leukaemia",
          "childhood precursor B-lymphoblastic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute B-lymphoblastic leukemia occurring in children."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000872"
    },
    {
      "id": 4634,
      "label": "primary central nervous system lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        4753,
        5530,
        6694,
        17548,
        17660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3234",
          "EFO:1000157",
          "GARD:0009318",
          "ICD9:200.5",
          "MEDGEN:79187",
          "MedDRA:10036685",
          "NCIT:C9301",
          "NORD:2002",
          "ONCOTREE:PCNSL",
          "Orphanet:46135",
          "SCTID:307649006",
          "UMLS:C0280803",
          "icd11.foundation:1133193893"
        ],
        "synonyms": [
          "CNS lymphoma",
          "PCNSL",
          "central nervous system lymphoma",
          "lymphoma of central nervous system",
          "malignant lymphomas of CNS",
          "malignant lymphomas of the CNS",
          "microglioma",
          "primary CNS lymphoma",
          "primary brain lymphoma",
          "primary central nervous system lymphoma",
          "primary lymphoma, CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin or Hodgkin lymphoma that arises in the brain or spinal cord as a primary lesion. There is no evidence of lymphoma outside the central nervous system at the time of diagnosis."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002571"
    },
    {
      "id": 4646,
      "label": "thymus cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6916,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3277",
          "GARD:0023177",
          "ICD10CM:C37",
          "ICD9:164.0",
          "MEDGEN:155883",
          "NCIT:C4962",
          "SCTID:363434003",
          "UMLS:C0751552",
          "icd11.foundation:1718833206"
        ],
        "synonyms": [
          "thymic neoplasm",
          "thymic tumor",
          "thymic tumour",
          "Thymus cancer",
          "cancer of Thymus",
          "cancer of the Thymus",
          "cancer of thymus",
          "malignant Thymus neoplasm",
          "malignant Thymus tumor",
          "malignant Thymus tumour",
          "malignant neoplasm of Thymus",
          "malignant neoplasm of the Thymus",
          "malignant neoplasm of thymus",
          "malignant thymus neoplasm",
          "malignant tumor of Thymus",
          "malignant tumor of the Thymus",
          "malignant tumour of Thymus",
          "malignant tumour of the Thymus",
          "thymus cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas, thymic lymphomas, primary thymic carcinomas, and metastatic carcinomas from other anatomic sites."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002586"
    },
    {
      "id": 4790,
      "label": "solitary plasmacytoma of chest wall",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        5839,
        7255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3723",
          "GARD:0023235",
          "MEDGEN:232340",
          "NCIT:C6711",
          "UMLS:C1332936"
        ],
        "synonyms": [
          "chest wall plasmacytoma",
          "chest wall solitary plasmacytoma",
          "plasmacytoma of chest wall",
          "solitary plasmacytoma of chest wall",
          "solitary plasmacytoma of the chest wall"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A solitary plasmacytoma that arises from the chest wall."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002756"
    },
    {
      "id": 6193,
      "label": "dendritic cell sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6569,
        6816,
        19729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7849",
          "GARD:0019082",
          "MEDGEN:226984",
          "NCIT:C27260",
          "ONCOTREE:DCS",
          "Orphanet:86903",
          "SCTID:446643000",
          "UMLS:C1301364"
        ],
        "synonyms": [
          "dendritic cell sarcoma",
          "sarcoma of dendritic cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A sarcoma that involves the dendritic cell."
      },
      "child_count": 12,
      "reference_id": "MONDO:0004380"
    },
    {
      "id": 6467,
      "label": "Waldeyer's ring cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6398,
        23494
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8937",
          "GARD:0027700",
          "ICD10CM:C14.2",
          "ICD9:149.1",
          "MEDGEN:509279",
          "NCIT:C194063",
          "SCTID:187716008",
          "UMLS:C0153406"
        ],
        "synonyms": [
          "cancer of tonsillar ring",
          "malignant neoplasm of Waldeyer's ring",
          "malignant neoplasm of tonsillar ring",
          "malignant tonsillar ring neoplasm",
          "malignant tumour of Waldeyer's ring",
          "tonsillar ring cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A malignant neoplasm involving the tonsillar ring."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004685"
    },
    {
      "id": 7685,
      "label": "breast diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        3053,
        5548,
        18833
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000144",
          "GARD:0024299",
          "MEDGEN:267764",
          "NCIT:C40375",
          "UMLS:C1511306"
        ],
        "synonyms": [
          "breast DLBCL",
          "breast diffuse large B-cell lymphoma",
          "diffuse large B-cell lymphoma of breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A diffuse large B-cell lymphoma that arises from the breast. It is the most common type of primary breast lymphoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006117"
    },
    {
      "id": 7711,
      "label": "colon Burkitt lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        4182,
        8648,
        21140
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024311",
          "MEDGEN:272491",
          "NCIT:C27465",
          "UMLS:C1333083"
        ],
        "synonyms": [
          "Burkitt lymphoma of colon",
          "Burkitts lymphoma of colon",
          "colon Burkitt lymphoma",
          "colon Burkitt's lymphoma",
          "colon Burkitts lymphoma",
          "primary colon Burkitt's lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare Burkitt lymphoma that arises from the colon."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006150"
    },
    {
      "id": 7719,
      "label": "colorectal diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        18833,
        21564
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000191",
          "GARD:0024314",
          "MEDGEN:474460",
          "NCIT:C96503",
          "UMLS:C3272827"
        ],
        "synonyms": [
          "colorectal DLBCL",
          "colorectal diffuse large B-cell lymphoma",
          "colorectum diffuse large B-cell lymphoma",
          "diffuse large B-cell lymphoma of colorectum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A diffuse large B-cell lymphoma that arises from the colon or rectum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006158"
    },
    {
      "id": 7778,
      "label": "gastric mantle cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        18808,
        23066
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000272",
          "GARD:0024339",
          "MEDGEN:234300",
          "NCIT:C27440",
          "UMLS:C1333780"
        ],
        "synonyms": [
          "gastric mantle cell lymphoma",
          "mantle cell lymphoma of stomach",
          "mantle cell lymphoma of the stomach",
          "stomach mantle cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A mantle cell lymphoma that affects the stomach. It may arise as a solitary mass or it may be a component of multifocal lymphomatous polyposis of the gastrointestinal tract. It usually has an aggressive clinical course."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006225"
    },
    {
      "id": 7812,
      "label": "liver diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        6475,
        8660,
        18833
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000323",
          "GARD:0024354",
          "MEDGEN:473542",
          "NCIT:C96843",
          "UMLS:C2184126"
        ],
        "synonyms": [
          "diffuse large B-cell lymphoma of liver",
          "hepatic diffuse large B-cell lymphoma",
          "liver diffuse large B-cell lymphoma",
          "primary hepatic diffuse large B-cell lymphoma",
          "primary liver diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare diffuse large B-cell lymphoma that arises from the liver and the bulk of the tumor is located in the liver."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006268"
    },
    {
      "id": 7907,
      "label": "primary pulmonary diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        18833,
        20058
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000495",
          "GARD:0024392",
          "MEDGEN:1789549",
          "NCIT:C45605",
          "UMLS:C2200138"
        ],
        "synonyms": [
          "diffuse large B-cell lymphoma of lung",
          "high grade MALT lymphoma of the lung",
          "lung diffuse large B-cell lymphoma",
          "primary pulmonary diffuse large B-cell lymphoma",
          "pulmonary diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A diffuse large B-cell lymphoma that is localized to the lungs at the time of presentation. Signs and symptoms include cough, dyspnea, and hemoptysis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006387"
    },
    {
      "id": 7933,
      "label": "small intestinal Burkitt lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        4030,
        8648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024404",
          "MEDGEN:277650",
          "NCIT:C27409",
          "UMLS:C1335991"
        ],
        "synonyms": [
          "Burkitt lymphoma of small intestine",
          "Burkitts lymphoma of small intestine",
          "primary small intestinal Burkitt's lymphoma",
          "small intestinal Burkitt lymphoma",
          "small intestinal Burkitt's lymphoma",
          "small intestine Burkitt lymphoma",
          "small intestine Burkitt's lymphoma",
          "small intestine Burkitts lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A Burkitt lymphoma that arises from the small intestine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006416"
    },
    {
      "id": 7934,
      "label": "small intestinal diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        4030,
        18833
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000534",
          "GARD:0024405",
          "MEDGEN:474155",
          "NCIT:C96055",
          "UMLS:C3272522",
          "icd11.foundation:1578565768"
        ],
        "synonyms": [
          "diffuse large B-cell lymphoma of small intestine",
          "small intestinal diffuse large B-cell lymphoma",
          "small intestine diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A diffuse large B-cell lymphoma that arises from the small intestine."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006417"
    },
    {
      "id": 7935,
      "label": "small intestinal enteropathy-associated T-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        4030,
        6569,
        19298
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000535",
          "GARD:0024406",
          "MEDGEN:275445",
          "NCIT:C39610",
          "UMLS:C1519371"
        ],
        "synonyms": [
          "enteropathy-associated T-cell lymphoma of small intestine",
          "small intestinal EATL",
          "small intestinal enteropathy-type T-cell lymphoma",
          "small intestine enteropathy-associated T-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An enteropathy-associated T-cell lymphoma arising from the small intestine, most commonly the jejunum or ileum. Patients usually present with abdominal pain, often associated with intestinal perforation. There is often a history of celiac disease. The lymphoma cells are usually medium-sized to large and form an ulcerating mucosal lesion with invasion of the small intestinal wall. Villous atrophy is present in the adjacent small intestinal mucosa. In a minority of cases the lymphoma cells are medium-sized and form a monomorphic infiltrate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006418"
    },
    {
      "id": 7963,
      "label": "thyroid gland diffuse large B-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        18833,
        19677
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000587",
          "GARD:0024419",
          "MEDGEN:234429",
          "NCIT:C6046",
          "UMLS:C1336749"
        ],
        "synonyms": [
          "diffuse large B-cell lymphoma of the thyroid",
          "diffuse large B-cell lymphoma of the thyroid gland",
          "diffuse large B-cell lymphoma of thyroid",
          "diffuse large B-cell lymphoma of thyroid gland",
          "primary thyroid gland diffuse large B-cell lymphoma",
          "thyroid diffuse large B-cell lymphoma",
          "thyroid gland diffuse large B-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A diffuse large B-cell lymphoma primarily involving the thyroid gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006462"
    },
    {
      "id": 10907,
      "label": "plasma cell myeloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6702,
        6892
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9538",
          "EFO:0001378",
          "GARD:0007108",
          "ICD10CM:C90.0",
          "ICD9:203.0",
          "ICDO:9732/3",
          "MEDGEN:10122",
          "MESH:D009101",
          "MedDRA:10028228",
          "NCIT:C3242",
          "NORD:1469",
          "OMIM:254500",
          "ONCOTREE:PCM",
          "Orphanet:29073",
          "UMLS:C0026764",
          "icd11.foundation:1582389689",
          "icd11.foundation:526287100"
        ],
        "synonyms": [
          "Kahler disease",
          "Kahler's disease",
          "Multiple Myeloma",
          "medullary plasmacytoma",
          "multiple myeloma",
          "multiple myeloma, resistance to, Somatic mutation",
          "multiple myeloma, susceptibility to, Somatic mutation",
          "multiple myeloma/plasma cell myeloma",
          "myeloid neoplasm of plasma cell",
          "myeloma",
          "myeloma, multiple",
          "myeloma, plasma cell, malignant",
          "myelomatosis",
          "plasma cell myeloid neoplasm",
          "plasma cell myeloma",
          "Al amyloidosis",
          "amyloidosis, systemic",
          "myeloma - multiple"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)"
      },
      "child_count": 9,
      "reference_id": "MONDO:0009693"
    },
    {
      "id": 16569,
      "label": "indolent primary cutaneous B-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        16570,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020164",
          "MEDGEN:1843003",
          "Orphanet:178557",
          "UMLS:C5680499"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0015819"
    },
    {
      "id": 18353,
      "label": "systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2906,
        3028,
        5546,
        7744,
        17660
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070324",
          "GARD:0021562",
          "ICDO:9724/3",
          "MEDGEN:397492",
          "NCIT:C80374",
          "Orphanet:364033",
          "SCTID:721311006",
          "UMLS:C2699747"
        ],
        "synonyms": [
          "EBV-positive T-cell lymphoproliferative disorder of childhood",
          "systemic EBV+ T-cell LPD of childhood",
          "systemic EBV-positive T-cell lymphoma of childhood",
          "systemic EBV-positive T-cell lymphoproliferative disease of childhood",
          "systemic EBV-positive T-cell lymphoproliferative disorder of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare and very aggressive neoplastic disease emerging after a primary acute or chronic active EBV infection. It presents with persisting fever and malaise, hepatosplenomegaly with or without lymphadenopathy, liver failure, severe pancytopenia and a rapid progression towards multi-organ failure and hemophagocytic syndrome with a fatal issue. It is characterized by clonal proliferation of EBV-infected T cells with an activated cytotoxic phenotype."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018223"
    },
    {
      "id": 18937,
      "label": "mast cell sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        6816,
        9280
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:355",
          "EFO:1000364",
          "GARD:0018870",
          "ICD10CM:C96.22",
          "ICD9:202.6",
          "ICDO:9740/3",
          "MEDGEN:11322",
          "MESH:D012515",
          "NCIT:C9348",
          "ONCOTREE:MCSL",
          "Orphanet:66661",
          "SCTID:118615008",
          "UMLS:C0036221",
          "icd11.foundation:1993363632",
          "icd11.foundation:233404891"
        ],
        "synonyms": [
          "MCS",
          "mast cell sarcoma",
          "mast-cell sarcoma",
          "sarcoma of mast cell",
          "MCSL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare entity characterized by localized but destructive growth of a tumor consisting of highly atypical, immature mast cells.(WHO, 2001)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0019024"
    },
    {
      "id": 19300,
      "label": "subcutaneous panniculitis-like T-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        6569,
        16568,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070662",
          "EFO:1000552",
          "GARD:0010193",
          "ICD10CM:C86.3",
          "ICD9:202.70",
          "ICDO:9708/3",
          "MEDGEN:99306",
          "MESH:C537503",
          "NANDO:2200030",
          "NCIT:C6918",
          "OMIM:618398",
          "ONCOTREE:SPTCL",
          "Orphanet:86884",
          "SCTID:404133000",
          "UMLS:C0522624",
          "icd11.foundation:1550338805"
        ],
        "synonyms": [
          "SPTCL",
          "subcutaneous panniculitic T-cell lymphoma",
          "subcutaneous panniculitis-like T-cell lymphoma",
          "subcutaneous panniculitis-like T-cell lymphoma (Alpha/Beta type)",
          "subcutaneous panniculitis-like T-cell lymphoma, Alpha/Beta type",
          "T-CELL LYMPHOMA, SUBCUTANEOUS PANNICULITIS-LIKE"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic cutaneous lymphoma that has been recognized as a distinct subset of peripheral T-cell lymphomas originating and presenting primarily in the subcutaneous fat tissue."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019475"
    },
    {
      "id": 20376,
      "label": "bone marrow cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        4262,
        7055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025293",
          "MEDGEN:438070",
          "NCIT:C35501",
          "UMLS:C2703042"
        ],
        "synonyms": [
          "bone marrow cancer",
          "cancer of bone marrow",
          "malignant bone marrow neoplasm",
          "malignant bone marrow tumor",
          "malignant bone marrow tumour",
          "malignant neoplasm of bone marrow"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). --2003"
      },
      "child_count": 3,
      "reference_id": "MONDO:0021138"
    },
    {
      "id": 26273,
      "label": "primary vitreoretinal large b-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3028,
        5876,
        18833
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:695631"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0979292"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    },
    {
      "id": 6778,
      "label": "immune system disorder"
    }
  ]
}