{
  "id": 3032,
  "label": "benign endocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000627",
  "properties": {
    "xrefs": [
      "DOID:0060089",
      "ICD9:227.8",
      "ICD9:227.9",
      "MEDGEN:87577",
      "NCIT:C4621",
      "SCTID:92085000",
      "UMLS:C0347524"
    ],
    "synonyms": [
      "benign endocrine gland neoplasm",
      "benign endocrine gland tumor",
      "benign endocrine gland tumour",
      "benign endocrine neoplasm",
      "benign endocrine tumor",
      "benign endocrine tumour",
      "benign neoplasm of endocrine gland",
      "benign neoplasm of the endocrine gland",
      "benign tumor of endocrine gland",
      "benign tumor of the endocrine gland",
      "benign tumour of endocrine gland",
      "benign tumour of the endocrine gland",
      "endocrine gland benign neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A non-metastasizing, functioning or non-functioning neoplasm that arises from an endocrine organ. Representative examples include thyroid gland follicular adenoma and parathyroid gland adenoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 14,
  "parents": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003769",
          "ICD9:239.7",
          "MEDGEN:4044",
          "NCIT:C3010",
          "SCTID:387922007",
          "UMLS:C0014132"
        ],
        "synonyms": [
          "endocrine gland neoplasm (disease)",
          "endocrine gland tumor",
          "endocrine gland tumour",
          "endocrine neoplasm",
          "endocrine system neoplasm",
          "endocrine system tumor",
          "endocrine system tumour",
          "endocrine tumor",
          "endocrine tumour",
          "neoplasm of endocrine gland",
          "tumor of endocrine gland",
          "tumour of endocrine gland",
          "malignant endocrine tumor",
          "malignant endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. Representative examples include pituitary gland adenoma, pituitary gland carcinoma, thyroid gland carcinoma, carcinoid tumor, and neuroendocrine carcinoma."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002082"
    },
    {
      "id": 6887,
      "label": "benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060072",
          "DOID:0060084",
          "DOID:0060085",
          "EFO:0002422",
          "ICD10CM:D10-D36",
          "ICD10WHO:D10-D36",
          "ICD9:210-229",
          "ICD9:229.8",
          "ICD9:229.9",
          "ICDO:8000/0",
          "MEDGEN:39483",
          "NCIT:C3677",
          "SCTID:20376005",
          "UMLS:C0086692"
        ],
        "synonyms": [
          "benign neoplasm",
          "benign neoplasm (disease)",
          "neoplasm (disease), benign",
          "benign tumor",
          "benign tumour",
          "benign unclassifiable tumor",
          "benign unclassifiable tumour",
          "cell type benign neoplasm",
          "neoplasm, benign",
          "organ system benign neoplasm"
        ],
        "definition": "A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites."
      },
      "child_count": 29,
      "reference_id": "MONDO:0005165"
    }
  ],
  "children": [
    {
      "id": 3234,
      "label": "liver lipoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        6833,
        21432,
        25554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10190",
          "MEDGEN:232277",
          "NCIT:C5750",
          "UMLS:C1333970"
        ],
        "synonyms": [
          "hepatic lipoma",
          "lipoma of liver",
          "lipoma of the liver",
          "liver lipoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare benign adipose tissue neoplasm of the liver."
      },
      "child_count": 4,
      "reference_id": "MONDO:0000965"
    },
    {
      "id": 4494,
      "label": "liver hemangioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        4441,
        21432,
        25554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:271",
          "MEDGEN:66765",
          "NCIT:C3869",
          "SCTID:93469006",
          "UMLS:C0238246"
        ],
        "synonyms": [
          "angioma of liver",
          "hemangioma of liver",
          "hepatic angioma",
          "liver hemangioma",
          "angioma of the liver",
          "hemangioma of the liver",
          "hepatic hemangioma",
          "liver angioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hemangioma arising from the liver."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002404"
    },
    {
      "id": 5379,
      "label": "bile duct papillary neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2884,
        3032,
        4204,
        20714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5468",
          "ICDO:8503/0",
          "MEDGEN:360303",
          "NCIT:C6881",
          "UMLS:C1879344"
        ],
        "synonyms": [
          "IPN",
          "bile duct papillary epithelial neoplasm",
          "bile duct papillary neoplasm",
          "bile duct papillomatosis",
          "biliary papillomatosis",
          "intraductal papillary neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-invasive, papillary epithelial neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003455"
    },
    {
      "id": 6499,
      "label": "liver leiomyoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        3776,
        21432,
        25554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:917",
          "MEDGEN:232276",
          "NCIT:C5753",
          "UMLS:C1333968"
        ],
        "synonyms": [
          "hepatic leiomyoma",
          "leiomyoma of liver",
          "leiomyoma of the liver",
          "liver leiomyoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign smooth muscle neoplasm arising from the liver. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004723"
    },
    {
      "id": 7675,
      "label": "benign carotid body paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3032,
        20296,
        23665
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000108",
          "GARD:0024294",
          "MEDGEN:396868",
          "NCIT:C79950",
          "UMLS:C2698359"
        ],
        "synonyms": [
          "benign carotid body paraganglioma",
          "carotid body paraganglioma, benign",
          "benign chemodectoma",
          "chemodectoma, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carotid body paraganglioma that is confined to the site of origin, without metastatic potential."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006104"
    },
    {
      "id": 7678,
      "label": "benign thyroid gland neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        16048
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000122",
          "GARD:0024295",
          "ICD10CM:D34",
          "ICD9:226",
          "MEDGEN:102306",
          "NCIT:C3628",
          "SCTID:92439006",
          "UMLS:C0154038"
        ],
        "synonyms": [
          "benign neoplasm of the thyroid",
          "benign neoplasm of the thyroid gland",
          "benign neoplasm of thyroid",
          "benign neoplasm of thyroid gland",
          "benign neoplasm of thyroid glands",
          "benign thyroid gland neoplasm",
          "benign thyroid gland tumor",
          "benign thyroid gland tumour",
          "benign thyroid neoplasm",
          "benign thyroid tumor",
          "benign thyroid tumour",
          "benign tumor of the thyroid",
          "benign tumor of the thyroid gland",
          "benign tumor of thyroid",
          "benign tumor of thyroid gland",
          "benign tumour of the thyroid",
          "benign tumour of the thyroid gland",
          "benign tumour of thyroid",
          "benign tumour of thyroid gland",
          "thyroid gland benign neoplasm",
          "thyroid neoplasm, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm arising from the thyroid gland."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006107"
    },
    {
      "id": 17179,
      "label": "pineocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3032,
        20573,
        21613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081248",
          "EFO:1000476",
          "GARD:0008207",
          "HP:0030407",
          "ICDO:9361/1",
          "MEDGEN:183004",
          "MedDRA:10035059",
          "NANDO:2200092",
          "NCIT:C6966",
          "ONCOTREE:PINC",
          "Orphanet:251912",
          "SCTID:255045009",
          "UMLS:C0917890",
          "icd11.foundation:2055142333"
        ],
        "synonyms": [
          "Pineocytoma (WHO grade I)",
          "benign pinealoma",
          "pinealocytoma",
          "pineocytoma",
          "pineocytoma (disease)",
          "pineocytoma, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Pineocytoma is the least aggressive form of pineal parenchymal tumors, manifesting with symptoms such as Parinaud's syndrome (a group of eye movement abnormalities and pupil dysfunction, including deficiency in upward-gaze and convergence-retraction nystagmus), headaches, balance impairment, urinary incontinence, and changes in mood and that are not known to disseminate in a diffuse manner. They are usually associated with a good prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016723"
    },
    {
      "id": 18830,
      "label": "hepatocellular adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2884,
        3032,
        6714,
        21432,
        22952
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050868",
          "EFO:0000762",
          "GARD:0018847",
          "ICDO:8170/0",
          "MEDGEN:61655",
          "MESH:D018248",
          "MedDRA:10019827",
          "NCIT:C3758",
          "ONCOTREE:LIAD",
          "Orphanet:54272",
          "UMLS:C0206669",
          "icd11.foundation:1481070735"
        ],
        "synonyms": [
          "HCA",
          "adenoma of liver cells",
          "adenoma of the liver cells",
          "adenoma, hepatocellular, benign",
          "hepatocellular adenoma",
          "liver cell adenoma",
          "LIAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign epithelial neoplasm arising from the hepatocytes. Grossly, it appears as a soft, round mass which often contains areas of hemorrhage and necrosis. Morphologically, the neoplastic cells resemble normal hepatocytes and form plates separated by sinusoids. Most patients have a history of contraceptive or anabolic steroids use."
      },
      "child_count": 5,
      "reference_id": "MONDO:0018902"
    },
    {
      "id": 20563,
      "label": "benign neoplasm of pituitary gland",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2882,
        3032,
        3036,
        17888,
        20573
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:60009",
          "GARD:0025319",
          "ICD10CM:D35.2",
          "MEDGEN:141679",
          "NCIT:C4782",
          "SCTID:92296004",
          "UMLS:C0496901",
          "icd11.foundation:1871539651"
        ],
        "synonyms": [
          "benign neoplasm of pituitary",
          "benign neoplasm of the pituitary",
          "benign neoplasm of the pituitary gland",
          "benign pituitary gland neoplasm",
          "benign pituitary gland tumor",
          "benign pituitary gland tumour",
          "benign pituitary neoplasm",
          "benign pituitary tumor",
          "benign pituitary tumour",
          "benign tumor of pituitary",
          "benign tumor of pituitary gland",
          "benign tumor of the pituitary",
          "benign tumor of the pituitary gland",
          "benign tumour of pituitary",
          "benign tumour of pituitary gland",
          "benign tumour of the pituitary",
          "benign tumour of the pituitary gland",
          "pituitary gland benign neoplasm",
          "pituitary neoplasms, benign",
          "pituitary tumor, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the pituitary gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021439"
    },
    {
      "id": 20585,
      "label": "benign neoplasm of parathyroid gland",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        20525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:60008",
          "ICD10CM:D35.1",
          "ICD9:227.1",
          "MEDGEN:57814",
          "NCIT:C3630",
          "SCTID:92272009",
          "UMLS:C0154041",
          "icd11.foundation:455097662"
        ],
        "synonyms": [
          "benign neoplasm of parathyroid",
          "benign neoplasm of the parathyroid",
          "benign neoplasm of the parathyroid gland",
          "benign parathyroid gland neoplasm",
          "benign parathyroid gland tumor",
          "benign parathyroid gland tumour",
          "benign parathyroid neoplasm",
          "benign parathyroid tumor",
          "benign parathyroid tumour",
          "benign tumor of parathyroid",
          "benign tumor of parathyroid gland",
          "benign tumor of the parathyroid",
          "benign tumor of the parathyroid gland",
          "benign tumour of parathyroid",
          "benign tumour of parathyroid gland",
          "benign tumour of the parathyroid",
          "benign tumour of the parathyroid gland",
          "parathyroid gland benign neoplasm",
          "parathyroid tumor benign",
          "parathyroid tumour benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the parathyroid gland."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021463"
    },
    {
      "id": 20630,
      "label": "benign neoplasm of adrenal gland",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025326",
          "ICD10CM:D35.0",
          "ICD9:227.0",
          "MEDGEN:56330",
          "NCIT:C3629",
          "SCTID:91967007",
          "UMLS:C0154040",
          "icd11.foundation:2121003176"
        ],
        "synonyms": [
          "adrenal gland benign neoplasm",
          "benign adrenal gland neoplasm",
          "benign adrenal gland tumor",
          "benign adrenal gland tumour",
          "benign adrenal neoplasm",
          "benign adrenal tumor",
          "benign adrenal tumour",
          "benign neoplasm of the adrenal gland",
          "benign tumor of adrenal gland",
          "benign tumor of the adrenal gland",
          "benign tumour of adrenal gland",
          "benign tumour of the adrenal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the adrenal gland."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021511"
    },
    {
      "id": 20631,
      "label": "benign neoplasm of thymus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        3035,
        6916
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025327",
          "ICD10CM:D15.0",
          "ICD9:212.6",
          "MEDGEN:87526",
          "NCIT:C4458",
          "SCTID:92437008",
          "UMLS:C0345975",
          "icd11.foundation:1583331018"
        ],
        "synonyms": [
          "benign Thymus neoplasm",
          "benign Thymus tumor",
          "benign Thymus tumour",
          "benign neoplasm of the Thymus",
          "benign thymic neoplasm",
          "benign thymic tumor",
          "benign thymic tumour",
          "benign tumor of Thymus",
          "benign tumor of the Thymus",
          "benign tumour of Thymus",
          "benign tumour of the Thymus",
          "thymus benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the thymus."
      },
      "child_count": 3,
      "reference_id": "MONDO:0021512"
    },
    {
      "id": 24719,
      "label": "TMEM127-related tumor predisposition",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        3032,
        9540,
        17682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028019"
        ],
        "synonyms": [
          "TMEM127-related tumor predisposition"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the TMEM127 gene, characterized by an increased risk of paraganglioma and pheochromocytoma, as well as an increased risk of renal cell carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700345"
    },
    {
      "id": 24720,
      "label": "MAX-related tumor predisposition",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2903,
        3032,
        9540,
        17682
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028020"
        ],
        "synonyms": [
          "MAX-related tumor predisposition"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autosomal dominant tumor predisposition disorder caused by pathogenic variants in the MAX gene, characterized by an increased risk of pheochromocytoma and paraganglioma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700346"
    }
  ],
  "roots": [
    {
      "id": 4223,
      "label": "endocrine gland neoplasm"
    },
    {
      "id": 6887,
      "label": "benign neoplasm"
    }
  ]
}