{
  "id": 3052,
  "label": "integumentary system benign neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000652",
  "properties": {
    "xrefs": [
      "DOID:0060121"
    ],
    "synonyms": [
      "integumental system benign neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A benign neoplasm that involves the integumental system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4198,
      "label": "integumentary system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:16",
          "EFO:0010285",
          "MEDGEN:712400",
          "SCTID:128598002",
          "UMLS:C1290011"
        ],
        "synonyms": [
          "disease of integumental system",
          "disease or disorder of integumental system",
          "disorder of integumental system",
          "integumental system disease",
          "integumental system disease or disorder",
          "integumentary disease",
          "disorder of integument"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A disease involving the integumental system."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002051"
    },
    {
      "id": 6887,
      "label": "benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060072",
          "DOID:0060084",
          "DOID:0060085",
          "EFO:0002422",
          "ICD10CM:D10-D36",
          "ICD10WHO:D10-D36",
          "ICD9:210-229",
          "ICD9:229.8",
          "ICD9:229.9",
          "ICDO:8000/0",
          "MEDGEN:39483",
          "NCIT:C3677",
          "SCTID:20376005",
          "UMLS:C0086692"
        ],
        "synonyms": [
          "benign neoplasm",
          "benign neoplasm (disease)",
          "neoplasm (disease), benign",
          "benign tumor",
          "benign tumour",
          "benign unclassifiable tumor",
          "benign unclassifiable tumour",
          "cell type benign neoplasm",
          "neoplasm, benign",
          "organ system benign neoplasm"
        ],
        "definition": "A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites."
      },
      "child_count": 29,
      "reference_id": "MONDO:0005165"
    }
  ],
  "children": [
    {
      "id": 4316,
      "label": "Bartholin gland benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3031,
        3052,
        20353
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2068",
          "MEDGEN:83868",
          "SCTID:189130001",
          "UMLS:C0347500"
        ],
        "synonyms": [
          "Bartholin gland neoplasm",
          "tumor of Bartholin's gland",
          "tumour of Bartholin's gland",
          "major vestibular gland benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign neoplasm that affects the Bartholin gland. Representative examples include adenoma, adenomyoma, adenocarcinoma, and squamous cell carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002193"
    },
    {
      "id": 8040,
      "label": "hemangioma of subcutaneous tissue",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3052,
        7994,
        19144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13081",
          "GARD:0024438",
          "MEDGEN:146343",
          "NCIT:C8540",
          "SCTID:93473009",
          "UMLS:C0685200"
        ],
        "synonyms": [
          "angioma of subcutaneous tissue",
          "angioma of the subcutaneous tissue",
          "hemangioma of subcutaneous tissue",
          "hemangioma of superficial fascia",
          "hemangioma of the subcutaneous tissue",
          "subcutaneous angioma",
          "subcutaneous hemangioma",
          "subcutaneous tissue angioma",
          "subcutaneous tissue hemangioma",
          "superficial fascia hemangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A hemangioma arising from the subcutaneous soft tissues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006557"
    },
    {
      "id": 8485,
      "label": "adiposis dolorosa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3052,
        8054,
        19144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3928",
          "EFO:1000667",
          "GARD:0005750",
          "ICD9:272.8",
          "MEDGEN:1757",
          "MESH:D000274",
          "MedDRA:10001294",
          "NCIT:C84540",
          "NORD:1046",
          "OMIM:103200",
          "Orphanet:36397",
          "SCTID:71404003",
          "UMLS:C0001529",
          "Wikipedia:Adiposis_dolorosa"
        ],
        "synonyms": [
          "Adiposalgia",
          "Dercum disease",
          "Dercum's Disease",
          "Dercum's disease",
          "Neurolipomatosis",
          "adipose tissue rheumatism",
          "adiposis dolorosa",
          "lipomatosis dolorosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Adiposis dolorosa or Dercum's disease is characterized by the development of multiple, painful, subcutaneous lipomas in association with obesity, asthenia and fatigue, and range of mental disturbances including instability, depression, confusion, dementia and epilepsy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007070"
    },
    {
      "id": 9241,
      "label": "multiple symmetric lipomatosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3052,
        8054,
        19144,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14116",
          "EFO:1000737",
          "GARD:0006957",
          "MEDGEN:7349",
          "NCIT:C4392",
          "NORD:1392",
          "OMIM:151800",
          "Orphanet:2398",
          "SCTID:238902007",
          "UMLS:C0023804"
        ],
        "synonyms": [
          "Madelung disease",
          "Launois-Bensaude lipomatosis",
          "Madelung's Disease",
          "cephalothoracic lipodystrophy",
          "cervical symmetrical lipomatosis",
          "familial benign cervical lipomatosis",
          "lipodystrophy, cephalothoracic",
          "lipomatosis, familial benign cervical",
          "multiple symmetric lipomatosis",
          "multiple symmetrical lipomatosis",
          "Launois-Bensaude syndrome",
          "MSL",
          "Madelung's disease",
          "benign symmetrical lipomatosis",
          "familial symmetric lipomatosis",
          "lipomatosis, multiple symmetric"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare subcutaneous tissue disease characterized by growth of symmetric non-encapsulated masses of adipose tissue mostly around the face and neck with variable clinical repercussions (e.g. reduced neck mobility, compression of respiratory structures)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0007908"
    },
    {
      "id": 9242,
      "label": "familial multiple lipomatosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3052,
        6833,
        19144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070518",
          "GARD:0012925",
          "ICD9:214.8",
          "ICD9:214.9",
          "MEDGEN:698553",
          "MESH:D000071070",
          "OMIM:151900",
          "Orphanet:199276",
          "SCTID:766888002",
          "UMLS:C1275273"
        ],
        "synonyms": [
          "lipoma",
          "lipomatosis, familial multiple",
          "lipomatosis, multiple"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Familial multiple lipomatosis is a rare, benign, genetic skin disease characterized by numerous, painless, encapsulated lipomas located in the subcutaneous adipose tissue of the trunk and extremities, with relative sparing of the neck and shoulders. Association with gastroduodenal lipomatosis, brain anomalies or lipomatosis, and refractory epilepsy has been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007909"
    },
    {
      "id": 20337,
      "label": "intraductal breast papilloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3027,
        3052,
        4204,
        4205
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1626",
          "MEDGEN:65944",
          "NCIT:C3863",
          "SCTID:254848002",
          "SCTID:99571000119102",
          "UMLS:C0238034"
        ],
        "synonyms": [
          "breast papilloma",
          "duct papilloma of breast",
          "duct papilloma of the breast",
          "ductal breast papilloma",
          "intraductal breast papilloma",
          "intraductal papilloma of breast",
          "intraductal papilloma of the breast",
          "mammary duct papilloma",
          "papilloma of breast",
          "papilloma of the breast",
          "breast duct papilloma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A benign papillary neoplasm that arises anywhere in the ductal system of the breast. It is characterized by fibrovascular structures lined by benign epithelial and myoepithelial proliferations. Intraductal breast papillomas are classified as central, when they arise in large ducts, or peripheral, when they arise in the terminal ductal lobular units."
      },
      "child_count": 20,
      "reference_id": "MONDO:0021097"
    },
    {
      "id": 20489,
      "label": "adenoma of nipple",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3052,
        4203,
        4562
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8506/0",
          "MEDGEN:137752",
          "NCIT:C4192",
          "SCTID:302829009",
          "UMLS:C0334378"
        ],
        "synonyms": [
          "adenoma of the nipple",
          "nipple adenoma",
          "papillomatosis, subareolar duct",
          "subareolar duct papillomatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A adenoma that involves the nipple."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021301"
    },
    {
      "id": 20564,
      "label": "benign neoplasm of skin",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3052,
        4599
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:216.8",
          "ICD9:216.9",
          "MEDGEN:2197",
          "NCIT:C2896",
          "SCTID:92384009",
          "UMLS:C0004998"
        ],
        "synonyms": [
          "benign cutaneous neoplasm",
          "benign cutaneous tumor",
          "benign cutaneous tumour",
          "benign neoplasm of the skin",
          "benign skin neoplasm",
          "benign skin tumor",
          "benign skin tumour",
          "benign tumor of skin",
          "benign tumor of the skin",
          "benign tumour of skin",
          "benign tumour of the skin",
          "skin neoplasms, benign",
          "zone of skin benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the zone of skin."
      },
      "child_count": 24,
      "reference_id": "MONDO:0021440"
    }
  ],
  "roots": [
    {
      "id": 4198,
      "label": "integumentary system disorder"
    },
    {
      "id": 6887,
      "label": "benign neoplasm"
    }
  ]
}