{
  "id": 3151,
  "label": "bone remodeling disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000833",
  "properties": {
    "xrefs": [
      "DOID:0080005"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A bone disease that results in formation or resorption abnormalities located in bone."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7061,
      "label": "bone disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6893
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080001",
          "EFO:0004260",
          "ICD10CM:M80-M85",
          "ICD9:731.8",
          "ICD9:733.99",
          "MEDGEN:14182",
          "MESH:D001847",
          "NANDO:2100291",
          "NANDO:2100293",
          "SCTID:76069003",
          "UMLS:C0005940"
        ],
        "synonyms": [
          "bone element disease",
          "bone element disease or disorder",
          "disease of bone element",
          "disease or disorder of bone element",
          "disorder of bone element",
          "rare bone disease related to a common gene or pathway defect"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Diseases of bones."
      },
      "child_count": 27,
      "reference_id": "MONDO:0005381"
    }
  ],
  "children": [
    {
      "id": 3153,
      "label": "bone resorption disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080011",
          "MEDGEN:14188",
          "MESH:D001862",
          "UMLS:C0005974"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disease that has its basis in the disruption of bone resorption. Bone resorption is a process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products."
      },
      "child_count": 3,
      "reference_id": "MONDO:0000837"
    },
    {
      "id": 3155,
      "label": "fibrous dysplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080031",
          "GARD:0006444",
          "ICD9:733.29",
          "MEDGEN:120444",
          "MESH:D005357",
          "MedDRA:10016664",
          "NCIT:C34609",
          "NORD:1147",
          "Orphanet:249",
          "SCTID:10623005",
          "SCTID:254145001",
          "UMLS:C0259779",
          "icd11.foundation:1704766818"
        ],
        "synonyms": [
          "fibrous dysplasia of bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A genetic, non-inheritable disorder caused by osteoblastic differentiation defects that result in the replacement of bone marrow and trabecular bone by fibrous stroma and immature bone. It usually affects a single bone and less frequently multiple bones. Skull, femur, tibia, and humerus are the most frequently affected bones. It manifests with pain, deformities, and fractures."
      },
      "child_count": 3,
      "reference_id": "MONDO:0000845"
    },
    {
      "id": 3323,
      "label": "osteomalacia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151,
        25070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10573",
          "HP:0002749",
          "ICD9:268.2",
          "MEDGEN:14533",
          "MESH:D010018",
          "NCIT:C26838",
          "SCTID:4598005",
          "UMLS:C0029442"
        ],
        "synonyms": [
          "osteomalacia",
          "osteomalacia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet. The most common symptoms are bone pain and muscle weakness. When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003"
      },
      "child_count": 2,
      "reference_id": "MONDO:0001068"
    },
    {
      "id": 4308,
      "label": "hyperostosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:205",
          "ICD10CM:M89.3",
          "ICD9:733.99",
          "MEDGEN:9366",
          "MESH:D015576",
          "NCIT:C34712",
          "SCTID:203514008",
          "UMLS:C0020492"
        ],
        "synonyms": [
          "bone hypertrophy",
          "hypertrophy of bone",
          "hypertrophy of bone (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Excessive thickening of bone."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002185"
    },
    {
      "id": 4938,
      "label": "osteosclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4254",
          "MEDGEN:10502",
          "MESH:D010026",
          "NANDO:2201022",
          "NCIT:C41236",
          "SCTID:49347007",
          "UMLS:C0029464",
          "icd11.foundation:2061303143"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Abnormally high bone density."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002933"
    },
    {
      "id": 7175,
      "label": "rickets",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10609",
          "EFO:0005583",
          "GARD:0005700",
          "HP:0002748",
          "ICD9:268.0",
          "MEDGEN:48470",
          "MESH:D012279",
          "NCIT:C26878",
          "SCTID:41345002",
          "UMLS:C0035579"
        ],
        "synonyms": [
          "rachitis",
          "rickets",
          "rickets (disease)",
          "vitamin D hydroxylation-deficient rickets",
          "active rickets",
          "hypovitaminosis D",
          "nutritional rickets",
          "vitamin D deficiency disease",
          "vitamin-D deficiency rickets"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005520"
    }
  ],
  "roots": [
    {
      "id": 7061,
      "label": "bone disorder"
    }
  ]
}