{
  "id": 3153,
  "label": "bone resorption disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000837",
  "properties": {
    "xrefs": [
      "DOID:0080011",
      "MEDGEN:14188",
      "MESH:D001862",
      "UMLS:C0005974"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A disease that has its basis in the disruption of bone resorption. Bone resorption is a process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3151,
      "label": "bone remodeling disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7061
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080005"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A bone disease that results in formation or resorption abnormalities located in bone."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000833"
    }
  ],
  "children": [
    {
      "id": 6992,
      "label": "osteoporosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3153,
        24803,
        25070
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11476",
          "EFO:0003882",
          "ICD10CM:M81",
          "ICD9:733.0",
          "ICD9:733.00",
          "ICD9:733.09",
          "MEDGEN:14535",
          "MESH:D010024",
          "NCIT:C3298",
          "OMIM:166710",
          "SCTID:64859006",
          "UMLS:C0029456",
          "icd11.foundation:2113001430"
        ],
        "synonyms": [
          "bone mineral density variation QTL, osteoporosis",
          "osteoporosis, postmenopausal",
          "osteoporosis, postmenopausal, susceptibility",
          "osteoporosis, susceptibility to",
          "fracture, hip, susceptibility to",
          "osteoporosis, involutional"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss)."
      },
      "child_count": 21,
      "reference_id": "MONDO:0005298"
    },
    {
      "id": 7494,
      "label": "osteitis fibrosa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3153
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3341",
          "EFO:0007413",
          "MEDGEN:14529",
          "MESH:D010002",
          "NCIT:C34875",
          "SCTID:84727000",
          "UMLS:C0029405"
        ],
        "synonyms": [
          "Von Recklinghausen disease of Bone",
          "Von Recklinghausen's disease of Bone",
          "osteitis fibrosa cystica"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disorder that is characterized by bone cysts and fractures, resulting from hyperparathyroidism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005890"
    },
    {
      "id": 23239,
      "label": "lytic metastatic bone lesion",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3153
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:137065",
          "MESH:D010014",
          "NCIT:C35371",
          "SCTID:203522001",
          "UMLS:C0302313"
        ],
        "synonyms": [
          "lytic metastatic bone lesion",
          "osteolysis",
          "osteolytic lesion",
          "Osteolyses"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Dissolution of bone that particularly involves the removal or loss of calcium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043731"
    }
  ],
  "roots": [
    {
      "id": 3151,
      "label": "bone remodeling disease"
    }
  ]
}