{
  "id": 3186,
  "label": "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000914",
  "properties": {
    "xrefs": [
      "DOID:0111035",
      "GARD:0001049",
      "MEDGEN:1634330",
      "MESH:D046589",
      "MedDRA:10065551",
      "NCIT:C84606",
      "NORD:883",
      "OMIM:125310",
      "Orphanet:136",
      "SCTID:390936003",
      "UMLS:C4551768",
      "icd11.foundation:1621899838"
    ],
    "synonyms": [
      "cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy",
      "CADASIL",
      "CADASIL syndrome",
      "CADASIL type 1",
      "CADASIL1",
      "CASIL",
      "autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy type 1",
      "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1",
      "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1",
      "dementia, hereditary multi-infarct type",
      "hereditary multi-infarct dementia",
      "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy",
      "familial vascular leukoencephalopathy"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A CADASIL characterized by migraine, strokes, and white matter lesions that has material basis in heterozygous mutation in the NOTCH3 gene on chromosome 19p13."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2903,
      "label": "autosomal dominant disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050736",
          "ICD9:758.5",
          "MEDGEN:539206",
          "SCTID:11164009",
          "UMLS:C0265385"
        ],
        "synonyms": [
          "autosomal dominant disease or disorder",
          "autosomal dominant hereditary disorder",
          "autosomal dominant inherited disorder",
          "disease or disorder, autosomal dominant",
          "disease, autosomal dominant"
        ],
        "definition": "Autosomal dominant form of disease."
      },
      "child_count": 192,
      "reference_id": "MONDO:0000426"
    },
    {
      "id": 8822,
      "label": "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        5714,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13945",
          "GARD:0024558",
          "ICD9:323.9",
          "ICD9:447.8",
          "MEDGEN:199687",
          "NANDO:1200545",
          "OMIMPS:125310",
          "UMLS:C0751587"
        ],
        "synonyms": [
          "CADASIL",
          "cerebral arteriopathy with subcortical infaracts and leukoencephalopathy",
          "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy",
          "Casil",
          "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy",
          "dementia, hereditary multi-infarct type"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 9,
      "reference_id": "MONDO:0007432"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2903,
      "label": "autosomal dominant disease"
    },
    {
      "id": 8822,
      "label": "cerebral arteriopathy with subcortical infarcts and leukoencephalopathy"
    }
  ]
}