{
  "id": 3258,
  "label": "heart conduction disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0000992",
  "properties": {
    "xrefs": [
      "DOID:10273",
      "ICD9:426.6",
      "SCTID:44808001"
    ],
    "synonyms": [
      "cardiac conduction disease",
      "cardiac conduction disorder",
      "conduction disease of heart",
      "disease of cardiac conduction",
      "disorder of cardiac conduction"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A disease that has its basis in the disruption of the heart's electrical conduction system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6967,
      "label": "heart disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:114",
          "EFO:0003777",
          "ICD9:429.89",
          "ICD9:429.9",
          "ICD9:V47.2",
          "MEDGEN:5458",
          "MESH:D006331",
          "NCIT:C3079",
          "SCTID:56265001",
          "UMLS:C0018799",
          "icd11.foundation:1512587470"
        ],
        "synonyms": [
          "cardiac disease",
          "disease of heart",
          "disease or disorder of heart",
          "disorder of heart",
          "disorder of heart/pericardium",
          "heart disease",
          "heart disease or disorder",
          "heart disorder",
          "heart trouble",
          "heart/pericardial disease",
          "heart/pericardial disease or disorder",
          "heart/pericardial disorder",
          "heart/pericardial trouble"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease involving the heart and/or pericardium."
      },
      "child_count": 34,
      "reference_id": "MONDO:0005267"
    }
  ],
  "children": [
    {
      "id": 2916,
      "label": "short QT syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3258,
        26601
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050793",
          "GARD:0016650",
          "ICD9:426.89",
          "MEDGEN:378835",
          "MESH:C580439",
          "NCIT:C71060",
          "NORD:2019",
          "OMIMPS:609620",
          "Orphanet:51083",
          "SCTID:698272007",
          "UMLS:C2348199",
          "icd11.foundation:553392015"
        ],
        "synonyms": [
          "short QT syndrome",
          "ventricular arrhythmia associated with short QT syndrome",
          "familial short QT syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A genetic disease of the electrical system of the heart that consists of a constellation of signs and symptoms, consisting of a short QT interval on an EKG (< 300 ms) that does not significantly change with heart rate, tall and peaked T waves, and a structurally normal heart. Short QT syndrome appears to be inherited in an autosomal dominant pattern, and a few affected families have been identified"
      },
      "child_count": 8,
      "reference_id": "MONDO:0000453"
    },
    {
      "id": 2926,
      "label": "atrioventricular block",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3258,
        10115
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050820",
          "HP:0001678",
          "ICD9:426.10",
          "MEDGEN:13956",
          "MESH:D054537",
          "SCTID:233917008",
          "UMLS:C0004245"
        ],
        "synonyms": [
          "AV block",
          "AV nodal block",
          "AVB",
          "atrioventricular block",
          "atrioventricular block (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heart block that is initiated in the atrioventricular node."
      },
      "child_count": 8,
      "reference_id": "MONDO:0000465"
    },
    {
      "id": 2930,
      "label": "sinoatrial node disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3258,
        7113
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050824",
          "MEDGEN:98448",
          "UMLS:C0428908"
        ],
        "synonyms": [
          "disease of sinoatrial node",
          "disease or disorder of sinoatrial node",
          "disorder of sinoatrial node",
          "sinoatrial node disease",
          "sinoatrial node disease or disorder",
          "SA node",
          "sinuatrial node"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease involving the sinoatrial node."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000469"
    },
    {
      "id": 9960,
      "label": "Wolff-Parkinson-White syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3258,
        25068
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:384",
          "EFO:1001450",
          "HP:0001716",
          "ICD9:426.7",
          "MEDGEN:12162",
          "MESH:D014927",
          "NANDO:2200217",
          "NCIT:C35132",
          "OMIM:194200",
          "Orphanet:907",
          "SCTID:17869006",
          "UMLS:C0043202",
          "icd11.foundation:1091030330"
        ],
        "synonyms": [
          "WPW",
          "Wolff-Parkinson-White pattern (finding)",
          "Wolff-Parkinson-White syndrome",
          "Wolff-Parkinson-white syndrome (disease)",
          "ventricular familial preexcitation syndrome",
          "Wpw syndrome",
          "accessory atrioventricular pathways",
          "preexcitation syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A cardiac conduction disorder characterized by an electrocardiographic finding of ventricular pre-excitation, which is a short PR interval and a long QRS interval with a delta wave. Most individuals are asymptomatic; however they can experience periods of palpitations, shortness of breath or syncope during tachycardic episodes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008685"
    },
    {
      "id": 12581,
      "label": "postural orthostatic tachycardia syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3258,
        20466,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111154",
          "EFO:1000645",
          "GARD:0013591",
          "MEDGEN:226970",
          "MESH:D054972",
          "NCIT:C85020",
          "OMIM:604715",
          "Orphanet:443236",
          "SCTID:371073003",
          "UMLS:C1299624",
          "icd11.foundation:1533647472"
        ],
        "synonyms": [
          "POTS",
          "familial orthostatic tachycardia due to norepinephrine transporter deficiency",
          "irritable heart",
          "orthostatic intolerance due to NET deficiency",
          "soldiers heart",
          "Soldiers heart",
          "neurocirculatory asthenia",
          "orthostatic intolerance"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011479"
    },
    {
      "id": 16147,
      "label": "Brugada syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3258,
        4370,
        26601
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050451",
          "GARD:0001030",
          "ICD9:746.89",
          "MEDGEN:222975",
          "MESH:D053840",
          "MedDRA:10059027",
          "NCIT:C142891",
          "NORD:878",
          "OMIMPS:601144",
          "Orphanet:130",
          "SCTID:418818005",
          "UMLS:C1142166",
          "icd11.foundation:1250136584"
        ],
        "synonyms": [
          "Brugada syndrome",
          "Brugada type idiopathic ventricular fibrillation",
          "idiopathic ventricular fibrillation, Brugada type",
          "right bundle branch block, ST segment elevation, and sudden death syndrome",
          "sudden unexplained nocturnal death syndrome",
          "sudden unexpected nocturnal death syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A genetically heterogeneous condition characterized by complete or incomplete right bundle branch block accompanied by ST elevation in leads V1-V3. There is a high incidence of ventricular arrhythmia that may result in sudden death."
      },
      "child_count": 27,
      "reference_id": "MONDO:0015263"
    },
    {
      "id": 18166,
      "label": "catecholaminergic polymorphic ventricular tachycardia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3258,
        9929,
        20013
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060674",
          "GARD:0004421",
          "MEDGEN:1803763",
          "MESH:C536334",
          "NANDO:2200216",
          "NANDO:2200221",
          "OMIMPS:604772",
          "Orphanet:3286",
          "SCTID:419671004",
          "UMLS:C5574922",
          "icd11.foundation:976309888"
        ],
        "synonyms": [
          "CPVT",
          "bidirectional tachycardia induced by catecholamine",
          "catecholaminergic polymorphic ventricular tachycardia",
          "double tachycardia induced by catecholamines",
          "malignant paroxysmal ventricular tachycardia",
          "multifocal ventricular premature beats",
          "ventricular tachycardia, catecholaminergic polymorphic",
          "catecholamine-induced polymorphic ventricular tachycardia",
          "familial polymorphic ventricular tachycardia",
          "polymorphic catecholergic ventricular tachycardia",
          "stress-induced polymorphic ventricular tachycardia",
          "syncopal paroxysmal tachycardia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe genetic arrhythmogenic disorder characterized by adrenergically induced ventricular tachycardia (VT) manifesting as syncope and sudden death."
      },
      "child_count": 21,
      "reference_id": "MONDO:0017990"
    },
    {
      "id": 19311,
      "label": "progressive familial heart block",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3258,
        26601
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111073",
          "GARD:0010005",
          "ICD9:426.6",
          "OMIMPS:113900",
          "Orphanet:871",
          "SCTID:698249005",
          "SCTID:93130009",
          "icd11.foundation:1762068981"
        ],
        "synonyms": [
          "familial Lenègre disease",
          "familial Lev-Lenègre disease",
          "familial progressive heart block",
          "hereditary bundle branch defect",
          "familial progressive cardiac conduction defect"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A hereditary cardiac conduction disorder that may progress to complete atrioventricular (AV) block. The disease is either asymptomatic or manifests as dyspnea, dizziness, syncope, abdominal pain, heart failure or sudden death."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019490"
    },
    {
      "id": 20203,
      "label": "sinoatrial block",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3258
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:19984",
          "MESH:D012848",
          "SCTID:65778007",
          "UMLS:C0037188",
          "icd11.foundation:884453307"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heart block that is initiated in the sinoatrial node."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020806"
    },
    {
      "id": 25029,
      "label": "NKX2.5-related congenital, conduction and myopathic heart disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3258,
        6933
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026559"
        ],
        "synonyms": [
          "NKX2-5-related congenital, conduction and myopathic heart disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heart disease that includes congenital heart defects, abnormal cardiac conduction or myopathy. Congenital heart defects consists of any heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and hypoplastic left heart syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0800441"
    }
  ],
  "roots": [
    {
      "id": 6967,
      "label": "heart disorder"
    }
  ]
}