{
  "id": 3274,
  "label": "chronic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001014",
  "properties": {
    "xrefs": [
      "DOID:1036",
      "ICD9:208.10",
      "MEDGEN:220905",
      "NCIT:C3483",
      "SCTID:92812005",
      "UMLS:C1279296"
    ],
    "synonyms": [
      "chronic leukaemia (disease)",
      "chronic leukemia",
      "chronic leukemia (disease)",
      "leukaemia (disease), chronic",
      "leukemia (disease), chronic",
      "adult chronic leukaemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6789,
      "label": "leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1240",
          "EFO:0000565",
          "HP:0001909",
          "ICD9:207",
          "ICD9:207.8",
          "ICD9:207.80",
          "ICD9:208",
          "ICD9:208.8",
          "ICD9:208.80",
          "ICD9:208.9",
          "ICD9:208.90",
          "ICDO:9800/3",
          "MEDGEN:9725",
          "MESH:D007938",
          "NANDO:2100002",
          "NCIT:C3161",
          "SCTID:93143009",
          "UMLS:C0023418"
        ],
        "synonyms": [
          "blood (leukemia)",
          "leukaemia (disease)",
          "leukemia",
          "leukemia (disease)",
          "leukemia, disease",
          "leukemia, malignant",
          "leukemias",
          "leukemias, general",
          "leukaemia NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005059"
    }
  ],
  "children": [
    {
      "id": 3282,
      "label": "prolymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6710
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1039",
          "GARD:0011965",
          "ICD9:204.80",
          "ICDO:9832/3",
          "MEDGEN:6062",
          "MESH:D015463",
          "NCIT:C3181",
          "SCTID:110006004",
          "UMLS:C0023486"
        ],
        "synonyms": [
          "prolymphocytic leukaemia (B or T)",
          "prolymphocytic leukaemia (B or T-cell)",
          "prolymphocytic leukemia",
          "prolymphocytic leukemia (B or T)",
          "prolymphocytic leukemia (B or T-cell)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A mature B- or T- cell leukemia with progressive clinical course. It is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen."
      },
      "child_count": 6,
      "reference_id": "MONDO:0001023"
    },
    {
      "id": 6403,
      "label": "chronic monocytic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3274,
        6392
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8593",
          "GARD:0024075",
          "ICD9:206.1",
          "ICD9:206.10",
          "ICD9:206.11",
          "MEDGEN:9729",
          "NCIT:C34774",
          "SCTID:188745007",
          "UMLS:C0023466"
        ],
        "synonyms": [
          "monocytic leukemia, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (myeloid progenitor cells) in the bone marrow and other sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004614"
    },
    {
      "id": 6693,
      "label": "B-cell chronic lymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6694,
        6710,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1040",
          "EFO:0000095",
          "GARD:0006104",
          "ICD10CM:C91.1",
          "ICD9:204.1",
          "MEDGEN:44120",
          "MESH:D015451",
          "MedDRA:10008958",
          "NCIT:C3163",
          "NORD:971",
          "OMIM:151400",
          "Orphanet:67038",
          "UMLS:C0023434"
        ],
        "synonyms": [
          "B cell CLL",
          "B cell chronic lymphocytic leukaemia",
          "B cell chronic lymphocytic leukemia",
          "B cell lymphocytic leukaemia",
          "B cell lymphocytic leukemia",
          "B-CLL",
          "B-cell CLL",
          "B-cell chronic lymphocytic leukemia",
          "B-cell chronic lymphogenous leukaemia",
          "B-cell chronic lymphogenous leukemia",
          "B-cell chronic lymphoid leukaemia",
          "B-cell chronic lymphoid leukemia",
          "B-cell lymphocytic leukaemia",
          "B-cell lymphocytic leukemia",
          "BCLL",
          "CLL",
          "Chronic Lymphocytic Leukemia",
          "chronic B-cell lymphocytic leukaemia",
          "chronic B-cell lymphocytic leukemia",
          "chronic lymphatic leukemia",
          "chronic lymphocytic leukaemia (CLL)",
          "chronic lymphocytic leukemia",
          "chronic lymphocytic leukemia (CLL)",
          "chronic lymphogenous leukaemia",
          "chronic lymphogenous leukemia",
          "hematopoeitic - chronic lymphocytic leukaemia (CLL)",
          "hematopoeitic - chronic lymphocytic leukemia (CLL)",
          "lymphoplasmacytic leukemia",
          "leukemia, chronic LYMPHOCYTIC",
          "leukemia, chronic lymphatic",
          "leukemia, lymphocytic, chronic",
          "small lymphocytic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004948"
    },
    {
      "id": 16452,
      "label": "chronic eosinophilic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3274,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080367",
          "GARD:0020104",
          "ICDO:9964/3",
          "MEDGEN:91106",
          "MESH:C580364",
          "MedDRA:10065854",
          "NCIT:C4563",
          "ONCOTREE:CELNOS",
          "Orphanet:168940",
          "SCTID:188733003",
          "UMLS:C0346421"
        ],
        "synonyms": [
          "CEL",
          "CEL/hypereosinophilic syndrome",
          "chronic eosinophilic leukemia",
          "chronic eosinophilic leukemia/hypereosinophilic syndrome",
          "eosinophilic leukaemia",
          "eosinophilic leukemia",
          "CELNOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0015687"
    },
    {
      "id": 19277,
      "label": "chronic neutrophilic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3274,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080187",
          "EFO:1000179",
          "GARD:0010585",
          "ICDO:9963/3",
          "MEDGEN:6061",
          "MESH:D015467",
          "NCIT:C3179",
          "ONCOTREE:CNL",
          "Orphanet:86829",
          "SCTID:188734009",
          "UMLS:C0023481",
          "icd11.foundation:426734182"
        ],
        "synonyms": [
          "chronic neutrophilic leukemia",
          "neutrophilic leukaemia",
          "neutrophilic leukemia",
          "CNL"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare chronic myeloproliferative neoplasm characterized by neutrophilic leukocytosis. There is no detectable Philadelphia chromosome or BCR/ABL fusion gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019451"
    },
    {
      "id": 19294,
      "label": "T-cell large granular lymphocyte leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2906,
        3274,
        6778,
        7079
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050751",
          "GARD:0009812",
          "ICD9:204.80",
          "ICDO:9768/1",
          "ICDO:9831/1",
          "ICDO:9831/3",
          "MEDGEN:363038",
          "MedDRA:10065862",
          "NCIT:C4664",
          "ONCOTREE:TLGL",
          "Orphanet:86872",
          "SCTID:277569004",
          "UMLS:C1955861",
          "icd11.foundation:83430037"
        ],
        "synonyms": [
          "LGLL",
          "T gamma lymphoproliferative disorder",
          "T-LGL",
          "T-LGL leukaemia",
          "T-LGL leukemia",
          "T-cell LGL leukaemia",
          "T-cell LGL leukemia",
          "T-cell large gran. lymph. leuk.",
          "T-cell large granular lymphocyte leukemia",
          "T-cell large granular lymphocytic leukaemia",
          "T-cell large granular lymphocytic leukemia",
          "T-gamma lymphoproliferative disorder",
          "Tgamma large granular lymphocyte leukaemia",
          "Tgamma large granular lymphocyte leukemia",
          "large cell granular lymphogenous leukaemia",
          "large cell granular lymphogenous leukemia",
          "large cell granular lymphoid leukaemia",
          "large cell granular lymphoid leukemia",
          "large granular lymphocytic leukemia",
          "large granular lymphocytosis",
          "leukemia, large granular LYMPHOCYTIC, malignant",
          "proliferation of large granular lymphocytes",
          "LGL leukaemia",
          "LGL leukemia",
          "TLGL",
          "large granular lymphocyte leukaemia",
          "large granular lymphocyte leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "T-cell large granular lymphocyte leukemia (T-cell LGL leukemia) is a lymphoproliferative malignancy that arises from the mature T-cell (CD3+) lineage."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019469"
    },
    {
      "id": 19295,
      "label": "aggressive NK-cell leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2906,
        3274,
        5443,
        6706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1035",
          "GARD:0010493",
          "ICDO:9948/3",
          "MEDGEN:266235",
          "MedDRA:10028811",
          "NANDO:2200012",
          "NCIT:C8647",
          "ONCOTREE:ANKL",
          "Orphanet:86873",
          "SCTID:721310007",
          "UMLS:C1292777",
          "icd11.foundation:153957345"
        ],
        "synonyms": [
          "ANKCL",
          "NK cell leukaemia",
          "NK cell leukemia",
          "NK-cell LGL leukaemia",
          "NK-cell LGL leukemia",
          "NK-cell large granular lymphocyte leukaemia",
          "NK-cell large granular lymphocyte leukemia",
          "NK-cell leukaemia",
          "NK-cell leukemia",
          "aggressive NK-cell leukaemia (morphologic abnormality)",
          "aggressive NK-cell leukemia",
          "aggressive NK-cell leukemia (morphologic abnormality)",
          "aggressive NK-cell leukemia/lymphoma",
          "aggressive NK-cell lymphoma",
          "leukaemia (disease) of natural killer cell",
          "leukemia (disease) of natural killer cell",
          "natural Killer cell leukemia",
          "natural killer cell leukaemia (disease)",
          "natural killer cell leukemia",
          "natural killer cell leukemia (disease)",
          "ANKL",
          "aggressive NK cell leukaemia",
          "aggressive NK cell leukemia",
          "aggressive natural killer cell leukaemia",
          "aggressive natural killer cell leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019470"
    },
    {
      "id": 19790,
      "label": "chronic myelomonocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        7847,
        19728
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080188",
          "EFO:1001779",
          "GARD:0008225",
          "ICD10CM:C93.1",
          "ICDO:9945/3",
          "MEDGEN:44125",
          "MESH:D015477",
          "MedDRA:10009018",
          "NANDO:2200014",
          "NCIT:C3178",
          "ONCOTREE:CMML",
          "Orphanet:98823",
          "SCTID:127225006",
          "UMLS:C0023480",
          "icd11.foundation:2073226578"
        ],
        "synonyms": [
          "CMML",
          "chronic myelomonocytic leukaemia (CMML)",
          "chronic myelomonocytic leukemia",
          "chronic myelomonocytic leukemia (CMML)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020311"
    }
  ],
  "roots": [
    {
      "id": 6789,
      "label": "leukemia"
    }
  ]
}