{
  "id": 3354,
  "label": "toxic diffuse goiter",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001104",
  "properties": {
    "xrefs": [
      "DOID:10719",
      "ICD10CM:E05.0",
      "ICD9:242.00",
      "MEDGEN:488851",
      "SCTID:267374005",
      "UMLS:C0342122"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6233,
      "label": "hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7998",
          "EFO:0009189",
          "ICD9:242.90",
          "MEDGEN:6972",
          "MESH:D006980",
          "NANDO:2100119",
          "NANDO:2200329",
          "NCIT:C3123",
          "SCTID:34486009",
          "UMLS:C0020550"
        ],
        "synonyms": [
          "overactive thyroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004425"
    },
    {
      "id": 7075,
      "label": "goiter",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12176",
          "EFO:0004283",
          "HP:0000853",
          "ICD9:240.9",
          "MEDGEN:42270",
          "MESH:D006042",
          "NCIT:C26785",
          "SCTID:3716002",
          "UMLS:C0018021"
        ],
        "synonyms": [
          "Thyromegaly",
          "goiter",
          "goiter (disease)",
          "goitre (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005397"
    }
  ],
  "children": [
    {
      "id": 7047,
      "label": "Graves disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3354,
        7262,
        29358
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12361",
          "EFO:0004237",
          "ICD9:242.0",
          "MEDGEN:6677",
          "MESH:D006111",
          "NANDO:2200328",
          "NCIT:C3071",
          "SCTID:353295004",
          "UMLS:C0018213"
        ],
        "synonyms": [
          "Graves disease",
          "Basedow disease",
          "Graves' hyperthyroidism",
          "parry disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005364"
    }
  ],
  "roots": [
    {
      "id": 6233,
      "label": "hyperthyroidism"
    },
    {
      "id": 7075,
      "label": "goiter"
    }
  ]
}