{
  "id": 3356,
  "label": "kidney failure",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001106",
  "properties": {
    "xrefs": [
      "DOID:1074",
      "EFO:1002048",
      "ICD9:404.12",
      "ICD9:404.13",
      "ICD9:586",
      "MEDGEN:11177",
      "MESH:D051437",
      "NCIT:C4376",
      "SCTID:42399005",
      "UMLS:C0035078",
      "icd11.foundation:761526554"
    ],
    "synonyms": [
      "failure, renal",
      "renal failure",
      "renal failure syndrome",
      "renal insufficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6948,
      "label": "kidney disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4253
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:557",
          "EFO:0003086",
          "ICD9:583.81",
          "MEDGEN:9635",
          "MESH:D007674",
          "NCIT:C3149",
          "SCTID:90708001",
          "UMLS:C0022658"
        ],
        "synonyms": [
          "disease of kidney",
          "disease or disorder of kidney",
          "disorder of kidney",
          "kidney disease",
          "kidney disease or disorder",
          "kidney disorder",
          "renal disease",
          "renal disorder",
          "nephropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A disease involving the kidney."
      },
      "child_count": 57,
      "reference_id": "MONDO:0005240"
    }
  ],
  "children": [
    {
      "id": 4571,
      "label": "acute kidney injury",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3356,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3021",
          "ICD10CM:N17",
          "MEDGEN:388570",
          "MESH:D058186",
          "NCIT:C26808",
          "UMLS:C2609414",
          "icd11.foundation:476391827"
        ],
        "synonyms": [
          "AKI",
          "ARF",
          "acute kidney failure",
          "acute renal failure",
          "kidney failure, acute"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002492"
    },
    {
      "id": 8430,
      "label": "uremia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4676",
          "EFO:1001226",
          "MEDGEN:12008",
          "MESH:D014511",
          "MedDRA:10046369",
          "SCTID:44730006",
          "UMLS:C0041948"
        ],
        "synonyms": [
          "uremia of renal origin"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of renal insufficiency. Most uremic toxins are end products of protein or nitrogen catabolism, such as urea or creatinine. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms."
      },
      "child_count": 1,
      "reference_id": "MONDO:0007008"
    },
    {
      "id": 21358,
      "label": "chronic renal failure syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3356,
        6994
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:585.9",
          "MEDGEN:9637",
          "MESH:D051436",
          "NANDO:2100023",
          "NCIT:C9438",
          "SCTID:90688005",
          "UMLS:C0022661"
        ],
        "synonyms": [
          "CRF - chronic renal failure",
          "Chronic renal disease",
          "chronic kidney failure",
          "chronic renal failure",
          "chronic renal failure disease",
          "kidney failure, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Impairment of the renal function due to chronic kidney damage."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024327"
    }
  ],
  "roots": [
    {
      "id": 6948,
      "label": "kidney disorder"
    }
  ]
}