{
  "id": 3395,
  "label": "hydrocephalus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001150",
  "properties": {
    "xrefs": [
      "DOID:10908",
      "ICD10CM:G91",
      "ICD10WHO:G91",
      "MEDGEN:9335",
      "MESH:D006849",
      "NCIT:C3111",
      "SCTID:230745008",
      "UMLS:C0020255",
      "icd11.foundation:574533444"
    ],
    "synonyms": [
      "hydrocephalus, X-linked",
      "hydrocephalus, nonsyndromic, autosomal recessive"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 7209,
      "label": "brain disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:936",
          "EFO:0005774",
          "ICD9:348.3",
          "ICD9:348.30",
          "ICD9:348.8",
          "ICD9:348.9",
          "MEDGEN:14214",
          "MESH:D001927",
          "NCIT:C96413",
          "SCTID:81308009",
          "UMLS:C0006111"
        ],
        "synonyms": [
          "brain disease",
          "brain disease or disorder",
          "disease of brain",
          "disease or disorder of brain",
          "disorder of brain",
          "encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease affecting the brain or part of the brain."
      },
      "child_count": 71,
      "reference_id": "MONDO:0005560"
    }
  ],
  "children": [
    {
      "id": 4070,
      "label": "obstructive hydrocephalus",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3395
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14159",
          "ICD10CM:G91.1",
          "ICD9:331.4",
          "MEDGEN:108198",
          "NCIT:C116347",
          "SCTID:230746009",
          "UMLS:C0549423"
        ],
        "synonyms": [
          "non-communicating hydrocephalus"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of an obstruction at any location within the ventricular system that prevents cerebrospinal fluid flowing into the subarachnoid space."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001896"
    },
    {
      "id": 4192,
      "label": "communicating hydrocephalus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3395
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1573",
          "ICD10CM:G91.0",
          "ICD9:331.3",
          "MEDGEN:1058",
          "NCIT:C34501",
          "SCTID:271569006",
          "UMLS:C0009451",
          "icd11.foundation:186577228"
        ],
        "synonyms": [
          "non-obstructive hydrocephalus"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of impaired cerebrospinal fluid reabsorption by the arachnoid granulations."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002045"
    },
    {
      "id": 8792,
      "label": "craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3395,
        16468,
        19709,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0000998",
          "MEDGEN:325006",
          "MESH:C563973",
          "OMIM:123155",
          "Orphanet:1538",
          "SCTID:720813007",
          "UMLS:C1838347"
        ],
        "synonyms": [
          "Braddock-Jones-Superneau syndrome",
          "craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome",
          "Braddock Jones Superneau syndrome",
          "Dandy-Walker malformation with sagittal craniosynostosis and hydrocephalus",
          "HDCPH1",
          "hydrocephalus, autosomal dominant",
          "sagittal craniosynostosis, Dandy-Walker malformation and hydrocephalus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Craniosynostosis, Dandy-Walker malformation and hydrocephalus is a malformation disorder characterized by sagittal craniosynostosis, Dandy-Walker malformation, hydrocephalus, craniofacial dysmorphism (including dolichocephaly, hypertelorism, micrognathia, positional ear deformity) and variable developmental delay. The inheritance pattern appears to be autosomal dominant."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007401"
    },
    {
      "id": 16885,
      "label": "congenital hydrocephalus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3395,
        4427,
        20383,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006682",
          "ICD10CM:Q03",
          "ICD10WHO:Q03",
          "MEDGEN:9336",
          "MedDRA:10010506",
          "NANDO:2200822",
          "NCIT:C98876",
          "OMIMPS:236600",
          "Orphanet:2185",
          "SCTID:47032000",
          "UMLS:C0020256",
          "icd11.foundation:1878746673"
        ],
        "synonyms": [
          "congenital hydrocephalus",
          "HYC3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Hydrocephalus that is present at birth."
      },
      "child_count": 32,
      "reference_id": "MONDO:0016349"
    },
    {
      "id": 19209,
      "label": "megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3395,
        12458,
        24020,
        24270,
        29234
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010341",
          "MEDGEN:355095",
          "OMIMPS:603387",
          "Orphanet:83473",
          "SCTID:722036008",
          "UMLS:C1863924"
        ],
        "synonyms": [
          "MPPH syndrome",
          "megalencephaly and perisylvian polymicrogyria with postaxial polydactyly and hydrocephalus",
          "megalencephaly, polymicrogyria, and hydrocephalus (MPPH) syndrome",
          "megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome is characterized by megalencephaly, polymicrogyria, and hydrocephalus with variable polydactyly. It has been described in six unrelated patients. Intellectual deficit or slow development is also present. The mode of inheritance of this syndrome is unknown since all cases were sporadic."
      },
      "child_count": 15,
      "reference_id": "MONDO:0019375"
    },
    {
      "id": 20797,
      "label": "baker Vinters syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3395,
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:419861",
          "MESH:C537899",
          "UMLS:C2931659"
        ],
        "synonyms": [
          "hydrocephalus with cerebral aqueductal dysgenesis and craniofacial anomalies"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A very rare syndrome characterized by craniosynostosis (premature fusion of skull bones), hydrocephalus (an abnormal increase of cerebrospinal fluid in the ventricles of the brain) and abnormal development of the channel or duct in the middle of the brain that connects the third and fourth ventricles. This is an n-of-1 use case where only one patient or family has been described with this disorder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021966"
    },
    {
      "id": 23147,
      "label": "palmer pagon syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3395
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004199",
          "MEDGEN:419886",
          "MESH:C538107",
          "Orphanet:2184",
          "UMLS:C2931734"
        ],
        "synonyms": [
          "familial hydrocephalus with a low-insertion umbilicus",
          "hydrocephaly - low insertion umbilicus"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043164"
    }
  ],
  "roots": [
    {
      "id": 7209,
      "label": "brain disorder"
    }
  ]
}