{
  "id": 3448,
  "label": "acute respiratory failure",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001208",
  "properties": {
    "xrefs": [
      "ICD10CM:J96.0",
      "ICD9:518.81",
      "MEDGEN:75540",
      "NCIT:C27043",
      "SCTID:65710008",
      "UMLS:C0264490",
      "icd11.foundation:875272781"
    ],
    "synonyms": [
      "acute respiratory failure",
      "respiratory failure, acute"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "Life-threatening respiratory failure that develops rapidly. Causes include injury, sepsis, drug overdose, and pancreatitis. It manifests with dyspnea and cyanosis and may lead to cardiovascular shock."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 20092,
      "label": "acute disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24492
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:799.89",
          "MEDGEN:1738",
          "MESH:D000208",
          "SCTID:2704003",
          "UMLS:C0001314"
        ],
        "synonyms": [
          "acute disease",
          "acute diseases",
          "disease, acute"
        ],
        "definition": "Disease having a short and relatively severe course."
      },
      "child_count": 119,
      "reference_id": "MONDO:0020683"
    },
    {
      "id": 20352,
      "label": "respiratory failure",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6971
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11162",
          "EFO:0009686",
          "ICD9:518.83",
          "MEDGEN:257837",
          "MESH:D012131",
          "NCIT:C26872",
          "SCTID:39871006",
          "UMLS:C1145670",
          "icd11.foundation:370028006"
        ],
        "synonyms": [
          "failure, respiratory",
          "respiratory failure",
          "acute respiratory failure",
          "chronic respiratory failure",
          "acute and chronic respiratory failure",
          "acute-on-chronic respiratory failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021113"
    }
  ],
  "children": [
    {
      "id": 3447,
      "label": "neonatal respiratory failure",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11161",
          "ICD10CM:P28.5",
          "ICD9:770.84",
          "MEDGEN:105483",
          "SCTID:95619009",
          "UMLS:C0521648"
        ],
        "synonyms": [
          "respiratory failure of newborn"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001207"
    },
    {
      "id": 7995,
      "label": "acute respiratory distress syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3448,
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000637",
          "ICD10CM:J80",
          "MEDGEN:1812214",
          "MedDRA:10001052",
          "NCIT:C3353",
          "UMLS:C2887484",
          "icd11.foundation:1189702844"
        ],
        "synonyms": [
          "ARDS",
          "acute respiratory distress syndrome",
          "shock lung",
          "ALI",
          "Stiff lung",
          "acute lung injury",
          "increased-permeability pulmonary edema",
          "increased-permeability pulmonary oedema",
          "non-cardiogenic pulmonary edema",
          "non-cardiogenic pulmonary oedema"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006502"
    },
    {
      "id": 8364,
      "label": "pulmonary edema",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11396",
          "EFO:1001134",
          "ICD10CM:J81",
          "MEDGEN:11026",
          "MESH:D011654",
          "MedDRA:10037375",
          "NCIT:C26868",
          "SCTID:19242006",
          "UMLS:C0034063"
        ],
        "synonyms": [
          "edema, pulmonary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure)."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006932"
    }
  ],
  "roots": [
    {
      "id": 20092,
      "label": "acute disease"
    },
    {
      "id": 20352,
      "label": "respiratory failure"
    }
  ]
}