{
  "id": 3493,
  "label": "arteriovenous hemangioma/malformation",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001256",
  "properties": {
    "xrefs": [
      "CSP:0571-2717",
      "DOID:11294",
      "HP:0100026",
      "ICDO:9123/0",
      "MEDGEN:137780",
      "MESH:D001165",
      "NCIT:C2882",
      "SCTID:233982006",
      "UMLS:C0334533"
    ],
    "synonyms": [
      "arteriovenous angioma",
      "arteriovenous hemangioma",
      "arteriovenous hemangioma/malformation",
      "racemose aneurysm (morphologic abnormality)",
      "racemose hemangioma (morphologic abnormality)",
      "arteriovenous malformation",
      "cirsoid aneurysm"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A benign vascular lesion characterized by the presence of a complex network of communicating arterial and venous vascular structures."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 7994,
      "label": "hemangioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21322
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:255",
          "EFO:1000635",
          "HP:0001028",
          "ICD10CM:D18.0",
          "ICD9:228.0",
          "ICD9:228.00",
          "ICD9:228.09",
          "ICDO:9120/0",
          "MEDGEN:5477",
          "MESH:D006391",
          "NCIT:C3085",
          "ONCOTREE:HEMA",
          "SCTID:400210000",
          "UMLS:C0018916"
        ],
        "synonyms": [
          "benign hemangioma",
          "hemangioma",
          "hemangioma, benign",
          "angioma",
          "benign angioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A benign vascular lesion characterized by the formation of capillary-sized or cavernous vascular channels."
      },
      "child_count": 28,
      "reference_id": "MONDO:0006500"
    }
  ],
  "children": [
    {
      "id": 8561,
      "label": "arteriovenous malformations of the brain",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3493,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060688",
          "GARD:0003020",
          "MEDGEN:214590",
          "MESH:D002538",
          "NANDO:2100229",
          "NANDO:2200851",
          "NCIT:C2936",
          "OMIM:108010",
          "Orphanet:46724",
          "SCTID:234142008",
          "UMLS:C0917804",
          "icd11.foundation:153256729"
        ],
        "synonyms": [
          "arteriovenous malformation of the brain, somatic",
          "arteriovenous malformations of the brain",
          "cerebral arteriovenous malformation",
          "intracranial arteriovenous malformation",
          "intracranial haemorrhage in brain cerebrovascular malformations, susceptibility to, somatic mutation",
          "intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to, somatic mutation",
          "Bavm",
          "cerebral arteriovenous malformations",
          "intracranial AVM",
          "intracranial haemorrhage in brain arteriovenous malformations, susceptibility to",
          "intracranial hemorrhage in brain arteriovenous malformations, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cerebral arteriovenous malformation (AVM) is a congenital malformative communication between the veins and the arteries in the brain in the form of a nidus, an anatomical structure composed of dilated and tangled supplying arterioles and drainage veins with no intervening capillary bed, that can be asymptomatic or cause, depending on the location and the size of the AVM, headaches of varying severity, generalized or focal seizures, focalneurological defects (weakness, numbness, speech difficulties, vision loss) or potentially fatal intracranial hemorrhage in case the AVM ruptures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007154"
    },
    {
      "id": 16108,
      "label": "vein of Galen aneurysm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3493,
        5807,
        6420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005467",
          "MEDGEN:140912",
          "MESH:C536535",
          "NCIT:C98642",
          "Orphanet:1053",
          "SCTID:253194008",
          "UMLS:C0431420",
          "icd11.foundation:1884295064"
        ],
        "synonyms": [
          "vein of Galen arteriovenous malformations",
          "Galen vein aneurysm",
          "Galenic arteriovenous malformation",
          "VGAM",
          "ectasia or varix of the vein of Galen",
          "vein of Galen aneurysm malformation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Vein of Galen aneurysm is a rare formof arteriovenous malformation in which the embryonic precursor to the vein of Galen, a vein at the base of the brain, dilates causing too much blood to rush to the heart. This can lead to rapid heart failure. Other features may include increased head circumference resulting from hydrocephalus, unusually prominent veins on the face and scalp, developmental delay, persistent headache, and other neurological findings. Vein of Galen aneurysm is often recognized on an ultrasound late in pregnancy. In other cases, it is diagnosed after birth. Although the exact cause remains unknown, this condition appears to result from a defect in early fetal development. Treatment is aimed at decreasing the blood flow through the malformation while maximizing the blood supply to the brain. Minimally invasive surgical techniques are preferred, such as endovascular embolization."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015196"
    },
    {
      "id": 16257,
      "label": "cerebrofacial arteriovenous metameric syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3493
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012662",
          "MEDGEN:825110",
          "Orphanet:141189",
          "SCTID:703266007",
          "UMLS:C3839265",
          "icd11.foundation:1402414905"
        ],
        "synonyms": [
          "CAMS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disorder characterized by vascular malformations that encompasses a spectrum of phenotypic expression involving arteriovenous malformations (AVMs) of the cerebral, orbital, and facial region."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015405"
    },
    {
      "id": 16329,
      "label": "facial arteriovenous malformation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3493
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012663",
          "MEDGEN:1842762",
          "Orphanet:156230",
          "UMLS:C5680665",
          "icd11.foundation:926860967"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Facial arteriovenous malformation is a rare vascular anomaly characterized by abnormal communication between arteries and veins, bypassing the capillary bed, located in the facial area. Lesions may be asymptomatic or may manifest with pain, ulceration, pulsation, tinnitus, minor bleeding or potentially life-threatening hemorrhage, blurred vision, impaired hearing, headache, paresthesia, enlargement of facial bones with intraosseous lesions, intraosseous hemangiomas, and speech, breathing and swallowing difficulties, as well as neuropathy."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015500"
    },
    {
      "id": 18821,
      "label": "Cobb syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3493,
        5091,
        16218,
        19142,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011892",
          "ICD9:239.2",
          "MEDGEN:91079",
          "MedDRA:10068841",
          "NCIT:C4485",
          "Orphanet:53721",
          "SCTID:254774003",
          "UMLS:C0346068",
          "icd11.foundation:1451924695"
        ],
        "synonyms": [
          "Cobb's syndrome",
          "SAMS 1-31",
          "cutaneomeningospinal angiomatosis",
          "spinal arteriovenous metameric syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cobb syndrome is defined by the association of vascular cutaneous (venous or arteriovenous), muscular (arteriovenous), osseous (arteriovenous) and medullary (arteriovenous) lesions at the same metamere or spinal segment. This segmental distribution may involve one or many of the 31 metameres present in humans. Only 16% of the medullary lesions are multiple and have a clearly metameric distribution."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018893"
    },
    {
      "id": 19066,
      "label": "Foix-Alajouanine syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3493
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004163",
          "ICD9:323.9",
          "MEDGEN:141629",
          "Orphanet:79093",
          "SCTID:230379007",
          "UMLS:C0472347",
          "icd11.foundation:937824238"
        ],
        "synonyms": [
          "Subacute angiohypertrophic myelomalacia",
          "Subacute ascending necrotizing myelitis",
          "Subacute necrotizing myelitis",
          "angiodysgenetic necrotizing myelopathy",
          "familial osteosclerosis with abnormalities of the nervous system and meninges"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Foix-Alajouanine syndrome, also called subacute ascending necrotising myelitis, results from chronic congestion of the extrinsic pial veins of the spinal cord and of the intrinsic subpial network. It is characterized by progressive ascending deficit over a period of several months or years."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019196"
    },
    {
      "id": 19684,
      "label": "dural sinus malformation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3493
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019368",
          "MEDGEN:824993",
          "Orphanet:97339",
          "UMLS:C3839148",
          "icd11.foundation:454640405"
        ],
        "synonyms": [
          "cranial dural arteriovenous fistula",
          "cranial dural arteriovenous malformations"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019972"
    }
  ],
  "roots": [
    {
      "id": 7994,
      "label": "hemangioma"
    }
  ]
}