{
  "id": 3527,
  "label": "Horner syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001294",
  "properties": {
    "xrefs": [
      "DOID:11486",
      "ICD10CM:G90.2",
      "ICD9:337.09",
      "MEDGEN:5616",
      "MESH:D006732",
      "NCIT:C28155",
      "SCTID:192915005",
      "UMLS:C0019937",
      "icd11.foundation:178756462"
    ],
    "synonyms": [
      "Horner syndrome",
      "Horner's syndrome",
      "Bernard-Horner syndrome",
      "oculosympathetic palsy"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Horner's syndrome is a rare condition characterized by miosis (constriction of thepupil), ptosis (drooping of the upper eyelid), and anhidrosis (absence of sweating of the face). It iscaused by damage to the sympathetic nerves of the face. The underlying causes of Horner's syndrome vary greatly and may include a tumor, stroke, or other damage to a part of the brain called the brain stem ; injury to the carotid artery ;and trauma to the brachial plexus. In rare cases, Horner's syndrome is congenital (present from birth) and associated with a lack of pigmentation of the iris (colored part of the eye). Treatment of Horner's syndrome depends on the underlying cause."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 3533,
      "label": "autonomic neuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3525,
        6950
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2042-2001",
          "CSP:2049-9000",
          "DOID:0060054",
          "DOID:11504",
          "MEDGEN:82621",
          "NCIT:C27033",
          "SCTID:277879009",
          "UMLS:C0259749"
        ],
        "synonyms": [
          "autonomic nervous system peripheral neuropathy",
          "autonomic peripheral neuropathy",
          "peripheral neuropathy of autonomic nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An inherited or acquired peripheral neuropathy affecting the autonomic nervous system. It results in disruption of the involuntary body functions. Inherited causes include Fabry disease and porphyrias. Acquired causes include diabetes, uremia, hepatic disorders, vitamin deficiencies, toxins, and drug toxicities."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001300"
    }
  ],
  "children": [
    {
      "id": 9087,
      "label": "congenital Horner syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3527
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006670",
          "HP:0006837",
          "MEDGEN:327111",
          "MESH:C564178",
          "OMIM:143000",
          "Orphanet:91413",
          "UMLS:C1840475"
        ],
        "synonyms": [
          "congenital Claude-Bernard-Horner syndrome",
          "congenital Horner syndrome",
          "congenital Horner syndrome (disease)",
          "HORNER syndrome, congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Congenital Horner syndrome is a rare neurological disorder characterized by relative pupillary miosis and blepharoptosis, evident at birth, caused by interruption of the oculosympathetic innervation at any point along the neural pathway from the hypothalamus to the orbit. Often additional symptoms, such as enophthalmos, facial anhidrosis, iris heterochromia, conjunctival congestion, transient hypotonia and/or pupillary dilation lag, may be present. Association with birth trauma, neoplasms or vascular malformations has been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007735"
    }
  ],
  "roots": [
    {
      "id": 3533,
      "label": "autonomic neuropathy"
    }
  ]
}