{
  "id": 3640,
  "label": "trachea squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001419",
  "properties": {
    "xrefs": [
      "DOID:12003",
      "EFO:1000600",
      "MEDGEN:91059",
      "NCIT:C4448",
      "SCTID:254620000",
      "UMLS:C0345946",
      "icd11.foundation:1439188070"
    ],
    "synonyms": [
      "epidermoid carcinoma of the trachea",
      "epidermoid carcinoma of trachea",
      "squamous cell carcinoma of the trachea",
      "squamous cell carcinoma of trachea",
      "trachea epidermoid carcinoma",
      "trachea squamous cell carcinoma",
      "tracheal epidermoid carcinoma",
      "tracheal squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A rare squamous cell carcinoma that arises from the mucosal lining of the trachea. It usually grows as an intraluminal mass and later invades extraluminal structures. The majority of patients present with hemoptysis, coughing, dyspnea, or stridor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 5144,
      "label": "trachea carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3628,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4876",
          "EFO:1000599",
          "MEDGEN:315650",
          "NCIT:C9347",
          "UMLS:C1744708"
        ],
        "synonyms": [
          "cancer of trachea",
          "trachea cancer",
          "cancer of the trachea",
          "carcinoma of the trachea",
          "carcinoma of trachea",
          "trachea carcinoma",
          "tracheal carcinoma",
          "Pancoast's tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the trachea."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003184"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    }
  ],
  "children": [
    {
      "id": 6445,
      "label": "trachea carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3640,
        6473
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8802",
          "ICD10CM:D02.1",
          "ICD9:231.1",
          "MEDGEN:57816",
          "NCIT:C3639",
          "SCTID:92772005",
          "UMLS:C0154070"
        ],
        "synonyms": [
          "carcinoma in situ of the trachea",
          "carcinoma in situ of trachea",
          "severe epithelial dysplasia of trachea",
          "stage 0 trachea carcinoma",
          "trachea carcinoma in situ",
          "trachea in situ carcinoma",
          "tracheal carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the tracheal mucosa and is confined to the epithelial layer without evidence of further tissue invasion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004661"
    }
  ],
  "roots": [
    {
      "id": 5144,
      "label": "trachea carcinoma"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    }
  ]
}