{
  "id": 3689,
  "label": "neutropenia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001475",
  "properties": {
    "xrefs": [
      "DOID:1227",
      "HP:0001875",
      "ICD9:288.0",
      "ICD9:288.00",
      "MEDGEN:163121",
      "MESH:D009503",
      "SCTID:303011007",
      "UMLS:C0853697",
      "icd11.foundation:926492960"
    ],
    "synonyms": [
      "neutropenia",
      "neutropenic disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A decrease in the number of neutrophils found in the blood."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 3806,
      "label": "agranulocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5664
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12987",
          "ICD10CM:D70",
          "ICD10WHO:D70",
          "ICD9:288.8",
          "MEDGEN:7932",
          "MESH:D000380",
          "NCIT:C2863",
          "SCTID:417672002",
          "UMLS:C0001824",
          "icd11.foundation:1913706366"
        ],
        "synonyms": [
          "granulocytopenia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001609"
    }
  ],
  "children": [
    {
      "id": 3481,
      "label": "transient neonatal neutropenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3689
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11245",
          "GARD:0022906",
          "ICD10CM:P61.5",
          "ICD9:776.7",
          "MEDGEN:510688",
          "SCTID:55444004",
          "UMLS:C0158997"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001241"
    },
    {
      "id": 16076,
      "label": "constitutional neutropenia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3689,
        10564
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019809",
          "MEDGEN:1785816",
          "NCIT:C61242",
          "Orphanet:101987",
          "UMLS:C3805116",
          "icd11.foundation:87096615"
        ],
        "synonyms": [
          "congenital neutropenia",
          "genetic infantile agranulocytosis",
          "infantile genetic agranulocytosis",
          "Kostmann disease",
          "Kostmann neutropenia",
          "Kostmann syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare disorder characterized by recurrent infantile infections and absence of neutrophils in the peripheral blood."
      },
      "child_count": 26,
      "reference_id": "MONDO:0015134"
    },
    {
      "id": 18709,
      "label": "neonatal alloimmune neutropenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3689
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021929",
          "MEDGEN:543869",
          "Orphanet:464370",
          "SCTID:14333004",
          "UMLS:C0272176"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare acquired neutropenia characterized by isolated neutropenia in a newborn due to maternal alloimmunization against human neutrophil antigens (HNA) inherited from the father and present on fetal neutrophils, and subsequent increased breakdown of the latter. The condition is self-limiting and resolves after several weeks. It usually presents with only mild bacterial infections or may even be asymptomatic, although severe forms with sepsis and fatal outcome have also been reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018739"
    },
    {
      "id": 29331,
      "label": "ELANE-related neutropenia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3689,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028170"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Any neutropenia in which the cause of the disease is a mutation in the ELANE gene."
      },
      "child_count": 4,
      "reference_id": "MONDO:1060165"
    }
  ],
  "roots": [
    {
      "id": 3806,
      "label": "agranulocytosis"
    }
  ]
}