{
  "id": 3754,
  "label": "hepatic coma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001548",
  "properties": {
    "xrefs": [
      "DOID:12550",
      "GARD:0027582",
      "ICD9:070.42",
      "MEDGEN:6803",
      "SCTID:72836002",
      "UMLS:C0019147",
      "icd11.foundation:1021642894"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A syndrome characterized by central nervous system dysfunction in association with liver failure, including portal-systemic shunts. Clinical features include lethargy and confusion (frequently progressing to coma); asterixis; nystagmus, pathologic; brisk oculovestibular reflexes; decorticate and decerebrate posturing; muscle spasticity; and bilateral extensor plantar reflexes (see reflex, babinski). electroencephalography may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3899,
      "label": "hepatic encephalopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7181,
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13413",
          "GARD:0027587",
          "ICD9:572.2",
          "MEDGEN:5513",
          "MESH:D006501",
          "NCIT:C79596",
          "SCTID:13920009",
          "UMLS:C0019151",
          "icd11.foundation:1769383160"
        ],
        "synonyms": [
          "portal-systemic encephalopathy",
          "Hepatoencephalopathy",
          "encephalopathy, hepatic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. It is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded.Signs and symptomsmay be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. They may includepersonality or moodchanges, intellectual impairment, abnormal movements,a depressed level of consciousness, and other symptoms.There are several theories regarding the exact cause, butdevelopment of the condition isprobablyat least partiallydue to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. Treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001711"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3899,
      "label": "hepatic encephalopathy"
    }
  ]
}