{
  "id": 3823,
  "label": "dementia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001627",
  "properties": {
    "xrefs": [
      "DOID:1307",
      "HP:0000726",
      "ICD10CM:F02",
      "ICD9:290.8",
      "ICD9:294.1",
      "ICD9:294.8",
      "MEDGEN:99229",
      "MESH:D003704",
      "NCIT:C4786",
      "SCTID:52448006",
      "UMLS:C0497327",
      "icd11.foundation:1468768235",
      "icd11.foundation:546689346"
    ],
    "synonyms": [
      "dementia",
      "dementia (disease)"
    ],
    "definition": "Loss of intellectual abilities interfering with an individual's social and occupational functions. Causes include Alzheimer's disease, brain injuries, brain tumors, and vascular disorders."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4186,
      "label": "cognitive disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4172
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1561",
          "ICD9:294.9",
          "MEDGEN:40371",
          "MESH:D019965",
          "NCIT:C92196",
          "SCTID:443265004",
          "UMLS:C0009241"
        ],
        "synonyms": [
          "cognitive disorder"
        ],
        "definition": "A disease affects cognitive processes."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002039"
    }
  ],
  "children": [
    {
      "id": 6434,
      "label": "vascular dementia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3823,
        12183
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8725",
          "EFO:0004718",
          "ICD10CM:F01",
          "ICD10CM:F01.5",
          "ICD10WHO:F01",
          "ICD9:290.4",
          "MEDGEN:41447",
          "MESH:D015140",
          "NCIT:C34525",
          "SCTID:429998004",
          "UMLS:C0011269",
          "icd11.foundation:1365258270"
        ],
        "synonyms": [
          "vascular dementia",
          "multi infarct dementia",
          "multifocal dementia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004648"
    },
    {
      "id": 6717,
      "label": "Alzheimer disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3823,
        7220
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10652",
          "HP:0002511",
          "ICD10CM:G30",
          "ICD10WHO:G30",
          "ICD9:290.1",
          "ICD9:331.0",
          "MEDGEN:1853",
          "MESH:D000544",
          "NCIT:C2866",
          "Orphanet:238616",
          "SCTID:142811000119104",
          "UMLS:C0002395",
          "birnlex:2092",
          "icd11.foundation:1611724421"
        ],
        "synonyms": [
          "AD",
          "Alzheimer dementia",
          "Alzheimer disease",
          "Alzheimer's dementia",
          "Alzheimer's disease",
          "Alzheimers disease",
          "presenile and senile dementia",
          "Alzheimer disease, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004975"
    },
    {
      "id": 8874,
      "label": "Lewy body dementia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2963,
        3823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12217",
          "EFO:0006792",
          "ICD10CM:G31.83",
          "ICD9:331.82",
          "MEDGEN:199874",
          "NCIT:C84826",
          "OMIM:127750",
          "Orphanet:1648",
          "SCTID:312991009",
          "UMLS:C0752347"
        ],
        "synonyms": [
          "DLB",
          "Lewy body dementia",
          "Lewy body disease",
          "cortical Lewy body disease",
          "dementia with Lewy bodies",
          "lewy body dementia, susceptibility to",
          "Lewy body variant of Alzheimer disease",
          "dementia, Lewy body",
          "diffuse Lewy body disease",
          "diffuse Lewy body disease with gaze palsy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007488"
    },
    {
      "id": 16360,
      "label": "hereditary dementia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3823,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020028",
          "MEDGEN:1842422",
          "Orphanet:158124",
          "UMLS:C5680680"
        ],
        "synonyms": [
          "genetic dementia"
        ],
        "definition": "An instance of dementia that is caused by an inherited genomic modification in an individual."
      },
      "child_count": 30,
      "reference_id": "MONDO:0015547"
    },
    {
      "id": 19687,
      "label": "dementia pugilistica",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081291",
          "GARD:0019371",
          "MEDGEN:508441",
          "MESH:D020208",
          "Orphanet:97353",
          "SCTID:230283005",
          "UMLS:C0149843"
        ],
        "synonyms": [
          "Boxer's dementia",
          "chronic traumatic encephalopathy",
          "punch-drunk syndrome"
        ],
        "definition": "Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from diffuse axonal injury; intracranial hemorrhages; brain edema; and other conditions. Clinical features may include dementia; focal neurologic deficits; persistent vegetative state; akinetic mutism; or coma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019976"
    },
    {
      "id": 19688,
      "label": "parkinsonism with dementia of Guadeloupe",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3823,
        20335
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019372",
          "MEDGEN:899794",
          "Orphanet:97355",
          "SCTID:715737004",
          "UMLS:C4275027",
          "icd11.foundation:773801248"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Parkinsonism with dementia of Guadeloupe is characterized by symmetrical bradykinesia, predominantly axial rigidity, postural instability with early falls and cognitive decline with prominent features of frontal lobe dysfunction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019977"
    },
    {
      "id": 20098,
      "label": "AIDS dementia complex",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3823,
        20721
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002608",
          "GARD:0008250",
          "ICD9:294.8",
          "MEDGEN:177",
          "MESH:D015526",
          "NCIT:C2864",
          "SCTID:421529006",
          "UMLS:C0001849"
        ],
        "synonyms": [
          "AIDS dementia",
          "AIDS dementia complex",
          "ADC",
          "ADC - Acquired immune deficiency syndrome dementia complex",
          "AIDS - Acquired immune deficiency syndrome dementia complex",
          "AIDS Dementia",
          "AIDS Dementia Complex",
          "AIDS Encephalopathies",
          "AIDS Encephalopathy",
          "AIDS RELAT DEMENTIA COMPLEX",
          "AIDS related Dementia Complex",
          "AIDS related cognitive impairment",
          "AIDS with dementia (disorder)",
          "AIDS-related Dementia Complex",
          "Acquired immune deficiency syndrome dementia complex",
          "Acquired immune deficiency syndrome-related dementia",
          "Acquired-Immune Deficiency Syndrome Dementia Complex",
          "Complex, AIDS Dementia",
          "Complex, AIDS-related Dementia",
          "DEMENTIA COMPLEX ACQUIRED IMMUNE DEFIC SYNDROME",
          "DEMENTIA COMPLEX AIDS RELAT",
          "Dementia Complex, AIDS",
          "Dementia Complex, AIDS related",
          "Dementia Complex, AIDS-related",
          "Dementia Complex, Acquired Immune Deficiency Syndrome",
          "Dementia associated with AIDS",
          "Dementia associated with acquired immunodeficiency syndrome",
          "Dementia, HIV",
          "Dementias, HIV",
          "Encephalopathies, AIDS",
          "Encephalopathies, HIV",
          "Encephalopathy, AIDS",
          "Encephalopathy, HIV",
          "HIV 1 Associated Cognitive Motor Complex",
          "HIV 1 Cognitive and Motor Complex",
          "HIV ASSOC COGNITIVE MOTOR COMPLEX",
          "HIV Associated Cognitive Motor Complex",
          "HIV Dementia",
          "HIV Dementias",
          "HIV Encephalopathies",
          "HIV Encephalopathy",
          "HIV associated cognitive and motor complex",
          "HIV encephalitis",
          "HIV-1 Cognitive and Motor Complex",
          "HIV-1-Associated Cognitive Motor Complex",
          "HIV-Associated Cognitive Motor Complex",
          "HIV-associated dementia",
          "acquired immune deficiency syndrome dementia complex",
          "acquired immune deficiency syndrome-related dementia"
        ],
        "definition": "A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0020689"
    },
    {
      "id": 22809,
      "label": "progressive dementia with neuroserpin inclusion bodies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3823
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022208",
          "ICD10CM:G40.3",
          "MEDGEN:1842194",
          "Orphanet:530303",
          "UMLS:C5680143"
        ],
        "synonyms": [
          "late-onset familial encephalopathy with neuroserpin inclusion bodies"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035161"
    },
    {
      "id": 24344,
      "label": "childhood-onset dementia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3823
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "childhood dementia",
          "pediatric dementia"
        ],
        "definition": "Dementia beginning in childhood or adolescence. This term denotes a group of conditions that cause early-onset progressive neurocognitive decline."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100625"
    }
  ],
  "roots": [
    {
      "id": 4186,
      "label": "cognitive disorder"
    }
  ]
}