{
  "id": 3853,
  "label": "brain cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001657",
  "properties": {
    "xrefs": [
      "CSP:2006-2736",
      "DOID:1319",
      "GARD:0027584",
      "ICD10CM:C71",
      "ICD9:191",
      "ICD9:191.8",
      "ICD9:191.9",
      "ICD9:239.6",
      "MEDGEN:57796",
      "MESH:D001932",
      "NCIT:C3568",
      "SCTID:428061005",
      "UMLS:C0153633",
      "icd11.foundation:189650925"
    ],
    "synonyms": [
      "brain neoplasm",
      "tumor of the brain",
      "tumour of the brain",
      "brain cancer",
      "brain neoplasms, malignant",
      "cancer of brain",
      "cancer of the brain",
      "malignant brain neoplasm",
      "malignant brain tumor",
      "malignant neoplasm of brain",
      "malignant neoplasm of the brain",
      "malignant tumor of brain",
      "malignant tumor of the brain",
      "malignant tumour of brain",
      "malignant tumour of the brain",
      "adult brain tumor",
      "adult brain tumour",
      "adult malignant brain neoplasm",
      "malignant primary brain neoplasm",
      "malignant primary brain tumor",
      "malignant primary brain tumour",
      "malignant tumor of adult brain",
      "malignant tumour of adult brain",
      "BT - brain tumor",
      "BT - brain tumour",
      "brain neoplasm, adult",
      "brain tumor, adult",
      "neoplasm of unspecified nature of brain",
      "primary brain neoplasm",
      "primary brain tumor",
      "primary brain tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A primary or metastatic malignant neoplasm affecting the brain."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4753,
      "label": "central nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7479,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3620",
          "EFO:0000326",
          "GARD:0027614",
          "ICD9:239.7",
          "MEDGEN:87593",
          "MESH:D016543",
          "NANDO:2100007",
          "NCIT:C4627",
          "SCTID:126951006",
          "UMLS:C0348374"
        ],
        "synonyms": [
          "CNS neoplasm",
          "central nervous system tumor",
          "central nervous system tumour",
          "CNS cancer",
          "CNS malignant neoplasms",
          "CNS neoplasms, malignant",
          "cancer of CNS",
          "cancer of central nervous system",
          "cancer of the CNS",
          "cancer of the central nervous system",
          "central nervous system cancer",
          "central nervous system neoplasms, malignant",
          "central nervous system tumours",
          "malignant CNS neoplasm",
          "malignant CNS neoplasms",
          "malignant CNS tumor",
          "malignant CNS tumour",
          "malignant central nervous system neoplasm",
          "malignant central nervous system tumor",
          "malignant central nervous system tumour",
          "malignant neoplasm of CNS",
          "malignant neoplasm of central nervous system",
          "malignant neoplasm of the CNS",
          "malignant neoplasm of the central nervous system",
          "malignant tumor of CNS",
          "malignant tumor of central nervous system",
          "malignant tumor of the CNS",
          "malignant tumor of the central nervous system",
          "malignant tumour of CNS",
          "malignant tumour of central nervous system",
          "malignant tumour of the CNS",
          "malignant tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the central nervous system"
      },
      "child_count": 40,
      "reference_id": "MONDO:0002714"
    },
    {
      "id": 20429,
      "label": "brain neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7209,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003833",
          "MEDGEN:14216",
          "NCIT:C2907",
          "UMLS:C0006118"
        ],
        "synonyms": [
          "brain neoplasm (disease)",
          "brain neoplasms",
          "brain tumor",
          "brain tumour",
          "neoplasm of brain",
          "neoplasm of the brain",
          "tumor of brain",
          "tumor of the Brain",
          "tumour of brain",
          "tumour of the Brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the brain."
      },
      "child_count": 34,
      "reference_id": "MONDO:0021211"
    }
  ],
  "children": [
    {
      "id": 4214,
      "label": "supratentorial cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1659",
          "GARD:0027597",
          "MEDGEN:155589",
          "MESH:D015173",
          "NCIT:C4964",
          "UMLS:C0751589"
        ],
        "synonyms": [
          "malignant supratentorial neoplasm",
          "malignant supratentorial tumor",
          "malignant supratentorial tumour",
          "supratentorial neoplasms, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and brain STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002071"
    },
    {
      "id": 4334,
      "label": "brain germinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853,
        4998
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2127",
          "GARD:0023086",
          "MEDGEN:231457",
          "NCIT:C6284",
          "UMLS:C1332606"
        ],
        "synonyms": [
          "intracranial germinoma",
          "brain germinoma (disease)",
          "germinoma of brain",
          "germinoma of the brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A germinoma (disease) that involves the brain."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002214"
    },
    {
      "id": 4335,
      "label": "brain sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853,
        4336
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2132",
          "GARD:0023087",
          "MEDGEN:272381",
          "NCIT:C5154",
          "UMLS:C1332607"
        ],
        "synonyms": [
          "brain sarcoma",
          "primary brain sarcoma",
          "sarcoma of brain",
          "sarcoma of the brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A sarcoma arising from the brain."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002216"
    },
    {
      "id": 4729,
      "label": "cerebral ventricle cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3541",
          "GARD:0027612",
          "ICD9:191.5",
          "MEDGEN:3325",
          "MESH:D002551",
          "NCIT:C2937",
          "SCTID:126958000",
          "UMLS:C0007798",
          "icd11.foundation:940756217"
        ],
        "synonyms": [
          "brain neoplasms, intraventricular",
          "brain ventricle cancer",
          "cancer of brain ventricle",
          "intraventricular brain neoplasm",
          "intraventricular brain neoplasms",
          "intraventricular brain tumor",
          "intraventricular brain tumour",
          "intraventricular neoplasm of brain",
          "intraventricular neoplasm of the brain",
          "intraventricular neoplasms",
          "intraventricular tumor of brain",
          "intraventricular tumor of the brain",
          "intraventricular tumour of brain",
          "intraventricular tumour of the brain",
          "malignant brain ventricle neoplasm",
          "malignant neoplasm of brain ventricle"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplasm that involves a brain ventricle. It may be a primary neoplasm arising from a brain ventricle, a metastasis from a distant anatomic site, or an extension of an invasive neoplasm from an adjacent brain structure."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002682"
    },
    {
      "id": 5088,
      "label": "infratentorial cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4706",
          "GARD:0027629",
          "MEDGEN:199689",
          "MESH:D015192",
          "NCIT:C4966",
          "UMLS:C0751593"
        ],
        "synonyms": [
          "brain neoplasm, infratentorial",
          "infratentorial neoplasms, malignant",
          "malignant infratentorial neoplasm",
          "malignant infratentorial tumor",
          "malignant infratentorial tumors",
          "malignant infratentorial tumour",
          "malignant infratentorial tumours"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Malignant neoplasms which arise or occur within the intracranial cavity below the tentorium cerebelli. This includes neoplasms within the brain and/or surrounding spaces."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003107"
    },
    {
      "id": 5116,
      "label": "intracranial primitive neuroectodermal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3043,
        3853
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4788",
          "GARD:0027631",
          "MEDGEN:577349",
          "NCIT:C5817",
          "UMLS:C0346292"
        ],
        "synonyms": [
          "brain primitive neuroectodermal tumor",
          "brain primitive neuroectodermal tumour",
          "intracranial primitive neuroectodermal neoplasm",
          "primitive neuroectodermal tumor of brain",
          "primitive neuroectodermal tumour of brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primitive neuroectodermal tumor that involves the brain."
      },
      "child_count": 8,
      "reference_id": "MONDO:0003142"
    },
    {
      "id": 7155,
      "label": "brain glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3853,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060108",
          "GARD:0024195",
          "MEDGEN:91163",
          "NCIT:C162993",
          "SCTID:254937005",
          "UMLS:C0349661"
        ],
        "synonyms": [
          "brain malignant glioma",
          "malignant glioma of brain"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant glioma that involves the brain."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005499"
    },
    {
      "id": 20498,
      "label": "cancer of cerebellum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3853,
        4920
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027887",
          "ICD10CM:C71.6",
          "ICD9:191.6",
          "MEDGEN:57797",
          "NCIT:C3569",
          "SCTID:449420002",
          "UMLS:C0153640"
        ],
        "synonyms": [
          "cancer of cerebellum",
          "cancer of the cerebellum",
          "cerebellar cancer",
          "cerebellar neoplasm, malignant",
          "cerebellar tumor, malignant",
          "cerebellum cancer",
          "malignant cerebellar neoplasm",
          "malignant cerebellar neoplasms",
          "malignant cerebellar tumor",
          "malignant cerebellar tumour",
          "malignant cerebellum neoplasm",
          "malignant neoplasm of cerebellum",
          "malignant neoplasm of the cerebellum",
          "malignant tumor of cerebellum",
          "malignant tumor of the cerebellum",
          "malignant tumour of cerebellum",
          "malignant tumour of the cerebellum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A cancer that involves the cerebellum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021317"
    },
    {
      "id": 29256,
      "label": "metastatic malignant neoplasm in the brain",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3853,
        21604
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028142",
          "MEDGEN:113095",
          "UMLS:C0220650"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm that has spread to the brain from another anatomic site."
      },
      "child_count": 0,
      "reference_id": "MONDO:1040026"
    }
  ],
  "roots": [
    {
      "id": 4753,
      "label": "central nervous system cancer"
    },
    {
      "id": 20429,
      "label": "brain neoplasm"
    }
  ]
}