{
  "id": 3893,
  "label": "pure red-cell aplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001705",
  "properties": {
    "xrefs": [
      "DOID:1340",
      "GARD:0007504",
      "ICD9:284.81",
      "MEDGEN:11154",
      "MESH:D012010",
      "NANDO:2100177",
      "NCIT:C34974",
      "NORD:1636",
      "SCTID:50715003",
      "UMLS:C0034902"
    ],
    "synonyms": [
      "PRCA",
      "Pure Red Cell Aplasia, Acquired",
      "pure red cell aplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A disease characterized by normocytic, normochromic anemia, low hematocrit, reticulocytopenia, and selective erythroid hypoplasia."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4394,
      "label": "anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2355",
          "HP:0001903",
          "ICD9:285.8",
          "ICD9:285.9",
          "MEDGEN:1526",
          "MESH:D000740",
          "NCIT:C2869",
          "SCTID:271737000",
          "UMLS:C0002871"
        ],
        "synonyms": [
          "anaemia (disease)",
          "anemia",
          "anemia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002280"
    }
  ],
  "children": [
    {
      "id": 16139,
      "label": "Diamond-Blackfan anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3893,
        3901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1339",
          "GARD:0006274",
          "MEDGEN:266045",
          "MESH:D029503",
          "MedDRA:10062989",
          "NANDO:1200890",
          "NANDO:2200614",
          "NCIT:C61236",
          "NORD:773",
          "OMIMPS:105650",
          "Orphanet:124",
          "SCTID:88854002",
          "UMLS:C1260899"
        ],
        "synonyms": [
          "Aase syndrome",
          "Aase-Smith II syndrome",
          "Blackfan-Diamond anaemia",
          "Blackfan-Diamond anemia",
          "DBA",
          "Diamond Blackfan Anemia",
          "Diamond-Blackfan anemia",
          "chronic constitutional pure red cell anemia",
          "congenital PRCA",
          "congenital hypoplastic anaemia",
          "congenital hypoplastic anemia",
          "congenital hypoplastic anemia, Blackfan-Diamond type",
          "congenital pure red cell aplasia",
          "erythrogenesis imperfecta",
          "inherited erythroblastopenia",
          "BDS",
          "Blackfan Diamond syndrome",
          "Red cell aplasia, pure hereditary",
          "anaemia Diamond Blackfan type",
          "anaemia congenital erythroid hypoplastic",
          "anemia Diamond Blackfan type",
          "anemia congenital erythroid hypoplastic",
          "aregenerative anaemia chronic congenital",
          "aregenerative anemia chronic congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A congenital aregenerative and often macrocytic anemia with erythroblastopenia."
      },
      "child_count": 44,
      "reference_id": "MONDO:0015253"
    },
    {
      "id": 19806,
      "label": "adult pure red cell aplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3893,
        19739
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010898",
          "MEDGEN:1647585",
          "NANDO:1200889",
          "NANDO:2200613",
          "NCIT:C70548",
          "Orphanet:98872",
          "SCTID:765748009",
          "UMLS:C4707560",
          "icd11.foundation:45753120"
        ],
        "synonyms": [
          "adult pure red-cell aplasia",
          "pure red-cell aplasia of adults",
          "acquired PRCA",
          "acquired pure red cell aplasia",
          "idiopathic pure red cell aplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Adult pure red cell aplasia is a rare acquired aplastic anemia characterized by a severe normocytic anemia with normal peripheral leukocyte and platelet counts, reticulocytopenia, high serum ferritin and transferrin saturation levels and isolated, almost complete absence of erythroblasts in the bone marrow with normal granulopoesis and megakaryopoesis. It presents with signs of severe anemia (fatigue, lethargy, pallor, intolerance of physical exercise and exertional dyspnea) in the absence of hemorrhagic symptoms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020338"
    }
  ],
  "roots": [
    {
      "id": 4394,
      "label": "anemia"
    }
  ]
}