{
  "id": 3927,
  "label": "hyperparathyroidism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001741",
  "properties": {
    "xrefs": [
      "DOID:13543",
      "EFO:0008506",
      "ICD9:252.0",
      "ICD9:252.00",
      "MEDGEN:6967",
      "MESH:D006961",
      "NANDO:2100123",
      "NANDO:2200343",
      "NCIT:C48259",
      "SCTID:66999008",
      "UMLS:C0020502",
      "icd11.foundation:9633776"
    ],
    "synonyms": [
      "hyperparathyroidism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 3463,
      "label": "parathyroid gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11201",
          "EFO:0005754",
          "ICD9:252",
          "ICD9:252.8",
          "ICD9:252.9",
          "MEDGEN:893009",
          "MESH:D010279",
          "NCIT:C26844",
          "SCTID:73132005",
          "UMLS:C4025822",
          "icd11.foundation:962023213"
        ],
        "synonyms": [
          "disease of parathyroid gland",
          "disease or disorder of parathyroid gland",
          "disorder of parathyroid gland",
          "parathyroid disease",
          "parathyroid gland disease",
          "parathyroid gland disease or disorder",
          "parathyroid gland diseases",
          "parathyroid gland disorder",
          "parathyroid gland disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the parathyroid gland."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001223"
    }
  ],
  "children": [
    {
      "id": 8390,
      "label": "secondary hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3927
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12466",
          "EFO:1001173",
          "HP:0000867",
          "MEDGEN:9368",
          "MESH:D006962",
          "MedDRA:10020708",
          "NCIT:C113335",
          "SCTID:91478007",
          "UMLS:C0020503",
          "icd11.foundation:1442752937"
        ],
        "synonyms": [
          "secondary hyperparathyroidism",
          "secondary hyperparathyroidism (disease)",
          "secondary hyperparathyroidism NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Overproduction of parathyroid hormone in response to influence external to the parathyroid glands."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006964"
    },
    {
      "id": 11973,
      "label": "primary hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3927
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11202",
          "EFO:0008519",
          "HP:0008200",
          "ICD10CM:E21.0",
          "ICD9:252.01",
          "MEDGEN:66354",
          "MESH:D049950",
          "NCIT:C48280",
          "SCTID:36348003",
          "UMLS:C0221002",
          "icd11.foundation:817194045"
        ],
        "synonyms": [
          "primary hyperparathyroidism",
          "primary hyperparathyroidism (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones."
      },
      "child_count": 1,
      "reference_id": "MONDO:0010837"
    },
    {
      "id": 16765,
      "label": "hereditary hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3927,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020408",
          "MEDGEN:1843372",
          "OMIMPS:145000",
          "Orphanet:208596",
          "UMLS:C5680826"
        ],
        "synonyms": [
          "genetic hyperparathyroidism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of hyperparathyroidism that is caused by an inherited genomic modification in an individual."
      },
      "child_count": 4,
      "reference_id": "MONDO:0016166"
    },
    {
      "id": 20370,
      "label": "tertiary hyperparathyroidism",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3927
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:588.89",
          "MEDGEN:488837",
          "NCIT:C114821",
          "SCTID:78200003",
          "UMLS:C0271858",
          "icd11.foundation:10683191"
        ],
        "synonyms": [
          "tertiary hyperparathyroidism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An overproduction of parathyroid hormone that is autonomous and often associated with chronic secondary hyperparathyroidism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021132"
    }
  ],
  "roots": [
    {
      "id": 3463,
      "label": "parathyroid gland disorder"
    }
  ]
}