{
  "id": 3937,
  "label": "cholestasis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001751",
  "properties": {
    "xrefs": [
      "DOID:13580",
      "ICD9:576.2",
      "MEDGEN:925",
      "MESH:D002779",
      "SCTID:30144000",
      "UMLS:C0008370"
    ],
    "synonyms": [
      "obstruction of bile duct"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Impairment of the bile flow caused by obstruction within the liver, or outside the liver in the bile duct system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4900,
      "label": "bile duct disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6624
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4138",
          "MEDGEN:2240",
          "MESH:D001649",
          "NCIT:C96716",
          "SCTID:118926004",
          "UMLS:C0005395"
        ],
        "synonyms": [
          "bile duct disease",
          "bile duct disease or disorder",
          "bile duct disorder",
          "disease of bile duct",
          "disease or disorder of bile duct",
          "disorder of bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disease involving the bile duct."
      },
      "child_count": 7,
      "reference_id": "MONDO:0002887"
    }
  ],
  "children": [
    {
      "id": 8211,
      "label": "extrahepatic cholestasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3937,
        7855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13619",
          "EFO:1000933",
          "MEDGEN:2241",
          "MESH:D001651",
          "MedDRA:10008637",
          "SCTID:8262006",
          "UMLS:C0005398"
        ],
        "synonyms": [
          "cholestasis of extrahepatic bile duct",
          "extrahepatic bile duct cholestasis",
          "extrahepatic cholestasis (finding)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Impairment of the bile flow caused by an obstruction in the portion of the bile duct system located outside of the liver."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006757"
    },
    {
      "id": 8313,
      "label": "obstructive jaundice",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3937,
        7855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13603",
          "EFO:1001068",
          "MEDGEN:43988",
          "MESH:D041781",
          "MedDRA:10029982",
          "SCTID:44018007",
          "UMLS:C0022354"
        ],
        "synonyms": [
          "obstructive hyperbilirubinemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A finding indicating increased bilirubin levels in the blood and urine, due to intrahepatic or extrahepatic obstruction of the biliary system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006874"
    },
    {
      "id": 10132,
      "label": "biliary atresia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3937,
        7855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13608",
          "GARD:0012010",
          "ICD10CM:Q44.2",
          "ICD9:751.61",
          "MEDGEN:14117",
          "MESH:D001656",
          "MedDRA:10003650",
          "NANDO:1200913",
          "NANDO:2200930",
          "NCIT:C34421",
          "NORD:1114",
          "Orphanet:30391",
          "SCTID:77480004",
          "UMLS:C0005411",
          "icd11.foundation:645741117"
        ],
        "synonyms": [
          "atresia of bile ducts",
          "biliary atresia, congenital",
          "congenital biliary atresia",
          "isolated atresia of bile ducts",
          "non-syndromic biliary atresia",
          "isolated biliary atresia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, biliary tract disease characterized by progressive obliterative cholangiopathy of the intra- and extrahepatic bile ducts, occurring in the embryonic/ perinatal period, leading to severe and persistent neonatal jaundice and acholic stool."
      },
      "child_count": 6,
      "reference_id": "MONDO:0008867"
    },
    {
      "id": 18964,
      "label": "intrahepatic cholestasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3937
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1852",
          "MEDGEN:3042",
          "MESH:D002780",
          "SCTID:235888006",
          "UMLS:C0008372"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A cholestasis characterized by impairment of the bile flow caused by obstruction located in the liver."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019072"
    },
    {
      "id": 22909,
      "label": "parenteral nutrition-associated cholestasis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3937
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022295",
          "MEDGEN:475934",
          "Orphanet:567983",
          "UMLS:C3274301",
          "icd11.foundation:1572634308"
        ],
        "synonyms": [
          "PNAC"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rare hepatic disease characterized by intrahepatic cholestasis and deterioration of liver function in patients receiving parenteral nutrition for extended periods of time (signs may appear as early as within the first two weeks of initiation of parenteral nutrition). The condition commonly occurs in neonates and usually resolves with transition to enteral feeding, although severe cases may progress to liver fibrosis, cirrhosis, and portal hypertension."
      },
      "child_count": 0,
      "reference_id": "MONDO:0035777"
    }
  ],
  "roots": [
    {
      "id": 4900,
      "label": "bile duct disorder"
    }
  ]
}