{
  "id": 4032,
  "label": "lacrimal apparatus disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001854",
  "properties": {
    "xrefs": [
      "DOID:1400",
      "EFO:0009455",
      "ICD9:375",
      "ICD9:375.69",
      "ICD9:375.89",
      "ICD9:375.9",
      "MEDGEN:5994",
      "MESH:D007766",
      "NCIT:C26809",
      "SCTID:31053003",
      "UMLS:C0022904"
    ],
    "synonyms": [
      "disease of lacrimal apparatus",
      "disease or disorder of lacrimal apparatus",
      "disorder of lacrimal apparatus",
      "disorder of lacrimal system",
      "lacrimal apparatus disease",
      "lacrimal apparatus disease or disorder",
      "lacrimal system disease",
      "lacrimal system disorder",
      "lachrymal system disorders"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 17,
  "parents": [
    {
      "id": 2924,
      "label": "eye adnexa disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4171
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050815",
          "EFO:0009546",
          "ICD10WHO:H00-H06",
          "MEDGEN:713201",
          "SCTID:118941004",
          "UMLS:C1290855"
        ],
        "synonyms": [
          "disease of ocular adnexa",
          "disease or disorder of ocular adnexa",
          "disorder of ocular adnexa",
          "ocular adnexa disease",
          "ocular adnexa disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          }
        ],
        "definition": "A disease involving the ocular adnexa."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000462"
    },
    {
      "id": 7019,
      "label": "eye disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4171,
        21415
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1242",
          "DOID:5614",
          "EFO:0003966",
          "ICD9:360",
          "ICD9:360.29",
          "ICD9:360.89",
          "ICD9:360.9",
          "ICD9:379.8",
          "ICD9:379.90",
          "MEDGEN:5092",
          "MESH:D005128",
          "NCIT:C26767",
          "SCTID:371405004",
          "UMLS:C0015397"
        ],
        "synonyms": [
          "disease of eye",
          "disease of eyeball of camera-type eye",
          "disease or disorder of eyeball of camera-type eye",
          "disorder of eye",
          "disorder of eyeball of camera-type eye",
          "eye disease",
          "eye disorder",
          "eyeball of camera-type eye disease",
          "eyeball of camera-type eye disease or disorder",
          "globe disease",
          "disease of eyeball",
          "disorder of eye proper",
          "disorder of eyeball",
          "disorder of globe"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma."
      },
      "child_count": 240,
      "reference_id": "MONDO:0005328"
    }
  ],
  "children": [
    {
      "id": 3226,
      "label": "lacrimal passage granuloma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10174",
          "ICD10CM:H04.81",
          "ICD9:375.81",
          "MEDGEN:509875",
          "SCTID:417563003",
          "UMLS:C0155253"
        ],
        "synonyms": [
          "granuloma of lacrimal passages"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0000957"
    },
    {
      "id": 3950,
      "label": "eversion of lacrimal punctum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13651",
          "ICD10CM:H04.52",
          "ICD9:375.51",
          "MEDGEN:509868",
          "SCTID:28244003",
          "UMLS:C0155243",
          "icd11.foundation:129526571"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001766"
    },
    {
      "id": 3951,
      "label": "stenosis of lacrimal punctum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032,
        5315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13653",
          "ICD10CM:H04.56",
          "ICD9:375.52",
          "MEDGEN:509869",
          "SCTID:74783009",
          "UMLS:C0155244"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001767"
    },
    {
      "id": 3952,
      "label": "stenosis of lacrimal passage",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032,
        5315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13654",
          "ICD9:375.53",
          "MEDGEN:509870",
          "SCTID:81345003",
          "UMLS:C0155245"
        ],
        "synonyms": [
          "stenosis of lacrimal canaliculi"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001768"
    },
    {
      "id": 3977,
      "label": "excessive tearing",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13757",
          "ICD10CM:H04.2",
          "ICD9:375.2",
          "ICD9:375.20",
          "MEDGEN:57518",
          "SCTID:193982009",
          "UMLS:C0152227"
        ],
        "synonyms": [
          "epiphora",
          "apparatus disease, lacrimal",
          "apparatus diseases, lacrimal",
          "disease, lacrimal apparatus",
          "diseases, lacrimal apparatus",
          "lacrimal apparatus disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Profuse lacrimation."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001793"
    },
    {
      "id": 4029,
      "label": "primary lacrimal atrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1399",
          "ICD9:375.13",
          "MEDGEN:509859",
          "SCTID:17093002",
          "UMLS:C0155229"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001851"
    },
    {
      "id": 4259,
      "label": "secondary lacrimal atrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1822",
          "ICD9:375.14",
          "MEDGEN:572969",
          "SCTID:75068001",
          "UMLS:C0339121"
        ],
        "synonyms": [
          "consecutive atrophy of lacrimal gland",
          "secondary atrophy of lacrimal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002124"
    },
    {
      "id": 4540,
      "label": "lacrimal system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032,
        4353
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:292",
          "MEDGEN:272790",
          "NCIT:C5102",
          "SCTID:416510003",
          "UMLS:C1334361",
          "icd11.foundation:456911769"
        ],
        "synonyms": [
          "cancer of lacrimal apparatus",
          "lacrimal apparatus cancer",
          "lacrimal system neoplasm",
          "lacrimal system neoplasms",
          "lacrimal system tumor",
          "lacrimal system tumour",
          "malignant lacrimal apparatus neoplasm",
          "malignant neoplasm of lacrimal apparatus",
          "neoplasm of lacrimal system",
          "neoplasm of the lacrimal system",
          "tumor of lacrimal system",
          "tumor of the lacrimal system",
          "tumour of lacrimal system",
          "tumour of the lacrimal system"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A cancer that involves the lacrimal apparatus."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002460"
    },
    {
      "id": 4582,
      "label": "stenosis of lacrimal sac",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3096",
          "ICD10CM:H04.57",
          "ICD9:375.54",
          "MEDGEN:509871",
          "SCTID:11772001",
          "UMLS:C0155246"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002511"
    },
    {
      "id": 5896,
      "label": "acute inflammation of lacrimal passage",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6970",
          "ICD9:375.3",
          "MEDGEN:572973",
          "SCTID:302900006",
          "UMLS:C0339129"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0004055"
    },
    {
      "id": 6670,
      "label": "chronic inflammation of lacrimal passage",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9935",
          "ICD9:375.4",
          "MEDGEN:509865",
          "SCTID:267653001",
          "UMLS:C0155239"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0004923"
    },
    {
      "id": 8190,
      "label": "dry eye syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032,
        4370,
        6538
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10140",
          "DOID:12895",
          "EFO:1000906",
          "ICD10CM:H04.12",
          "ICD9:375.15",
          "MEDGEN:4411",
          "MESH:D007638",
          "MESH:D015352",
          "MedDRA:10013777",
          "MedDRA:100233350",
          "NCIT:C34553",
          "SCTID:302896008",
          "SCTID:46152009",
          "UMLS:C0013238"
        ],
        "synonyms": [
          "dry eye",
          "dry eye syndrome",
          "dry eye(s)",
          "eye(s), dry",
          "keratoconjunctivitis sicca",
          "sicca, keratoconjunctivitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A syndrome characterized by dryness of the cornea and conjunctiva. It is usually caused by a deficiency in tear production. Symptoms include a feeling of burning eyes and a possible foreign body presence in the eye."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006733"
    },
    {
      "id": 19061,
      "label": "IgG4-related dacryoadenitis and sialadenitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3003,
        4032,
        18666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12900",
          "GARD:0007043",
          "MEDGEN:6399",
          "MESH:D008882",
          "MedDRA:10051457",
          "MedDRA:10052317",
          "NANDO:1200929",
          "NCIT:C34819",
          "Orphanet:79078",
          "SCTID:7826003",
          "UMLS:C0026103",
          "icd11.foundation:796087277"
        ],
        "synonyms": [
          "Mikulicz disease",
          "chronic dacryoadenitis and sialadenitis",
          "Mikulicz disease (former)",
          "Mikulicz syndrome (former)",
          "Mikulicz's disease (former)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019191"
    },
    {
      "id": 19417,
      "label": "isolated congenital alacrima",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016799",
          "MEDGEN:896261",
          "Orphanet:91416",
          "SCTID:717262004",
          "UMLS:C4273963"
        ],
        "synonyms": [
          "nonsyndromic congenital alacrima"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Congenital alacrima is characterized by deficient lacrimation (ranging from a complete absence of tears to hyposecretion of tears) that is present from birth."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019627"
    },
    {
      "id": 21539,
      "label": "disorder of lacrimal gland",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:536365",
          "SCTID:95766002",
          "UMLS:C0235228"
        ],
        "synonyms": [
          "disease of lacrimal gland",
          "disease or disorder of lacrimal gland",
          "disorder of lacrimal gland",
          "lacrimal gland disease",
          "lacrimal gland disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A disease that involves the lacrimal gland."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024625"
    },
    {
      "id": 23493,
      "label": "nasolacrimal duct disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:636806",
          "SCTID:95767006",
          "UMLS:C0521744"
        ],
        "synonyms": [
          "disease of nasolacrimal duct",
          "disease or disorder of nasolacrimal duct",
          "disorder of nasolacrimal duct",
          "nasolacrimal duct disease",
          "nasolacrimal duct disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A disease or disorder that involves the nasolacrimal duct."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044984"
    },
    {
      "id": 25091,
      "label": "syndromic lacrimal system disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4032
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022083",
          "MEDGEN:1842875",
          "Orphanet:519274",
          "UMLS:C5681383"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850007"
    }
  ],
  "roots": [
    {
      "id": 2924,
      "label": "eye adnexa disorder"
    },
    {
      "id": 7019,
      "label": "eye disorder"
    }
  ]
}