{
  "id": 4056,
  "label": "toxic shock syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001881",
  "properties": {
    "xrefs": [
      "DOID:14115",
      "GARD:0009560",
      "ICD10CM:A48.3",
      "ICD9:040.82",
      "MEDGEN:109414",
      "MESH:D012772",
      "NCIT:C35498",
      "NORD:1782",
      "Orphanet:36234",
      "SCTID:18504008",
      "UMLS:C0600327",
      "icd11.foundation:114886962"
    ],
    "synonyms": [
      "TSS",
      "TSS, toxic shock syndrome",
      "bacterial TSS",
      "bacterial toxic-shock syndrome",
      "shock syndrome (TSS), toxic",
      "syndrome (TSS), toxic shock",
      "toxic shock syndrome",
      "toxic shock syndrome, (TSS)",
      "staphylococcal toxic shock syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A rare acute life-threatening systemic bacterial noncontagious illness caused by exotoxins from bacteria of either the Streptococcus pyogenes or Staphylococcus aureus type. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2838,
      "label": "commensal bacterial infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050339"
        ],
        "synonyms": [
          "opportunistic bacterial infectious disease"
        ],
        "definition": "A bacterial infectious disease that results in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000315"
    },
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    }
  ],
  "children": [
    {
      "id": 19988,
      "label": "streptococcal toxic-shock syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4056,
        20725
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019709",
          "MEDGEN:575664",
          "MedDRA:10044251",
          "Orphanet:99918",
          "SCTID:240451000",
          "UMLS:C0343532",
          "icd11.foundation:197163558"
        ],
        "synonyms": [
          "Streptococcus caused toxic shock syndrome",
          "Streptococcus toxic shock syndrome",
          "streptococcal TSS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Streptococcal toxic-shock syndrome (streptococcal TSS) is an acute disease mediated by the production of superantigenic toxins characterized by the sudden onset of fever and other febrile symptoms, pain, multisystem organ involvement and potentially leading to coma, shock and death due to a Streptococcus pyogenes infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020544"
    },
    {
      "id": 19989,
      "label": "staphylococcal toxic-shock syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4056,
        17872
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019710",
          "ICD9:040.89",
          "MEDGEN:811401",
          "MedDRA:10044250",
          "Orphanet:99919",
          "SCTID:240450004",
          "UMLS:C3714602",
          "icd11.foundation:788554020"
        ],
        "synonyms": [
          "Staphylococcus caused toxic shock syndrome",
          "Staphylococcus toxic shock syndrome",
          "staphylococcal TSS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Staphylococcal toxic shock syndrome (staphylococcal TSS) is an acute disease mediated by the production of superantigenic toxins, characterized by high fever, skin rash followed by skin peeling, hypotension, vomiting, diarrhea and potentially leading to multisystem organ failure and caused by a Staphylococcus aureus bacterial infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020545"
    }
  ],
  "roots": [
    {
      "id": 2838,
      "label": "commensal bacterial infectious disease"
    },
    {
      "id": 4370,
      "label": "syndromic disease"
    }
  ]
}