{
  "id": 4104,
  "label": "endocrine pancreas disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001933",
  "properties": {
    "xrefs": [
      "DOID:1428",
      "ICD9:251",
      "MEDGEN:124407",
      "NCIT:C27067",
      "SCTID:17346000",
      "UMLS:C0271633"
    ],
    "synonyms": [
      "disease of endocrine pancreas",
      "disease or disorder of endocrine pancreas",
      "disorder of endocrine pancreas",
      "endocrine pancreas disease",
      "endocrine pancreas disease or disorder",
      "endocrine pancreas disorder",
      "disorder of islets of langerhans",
      "disorder of pancreatic islets"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A disease involving the endocrine pancreas."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 4455,
      "label": "pancreas disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:26",
          "EFO:0009605",
          "ICD10CM:K86.9",
          "ICD9:577.8",
          "ICD9:577.9",
          "MEDGEN:14583",
          "MESH:D010182",
          "NCIT:C26842",
          "SCTID:3855007",
          "UMLS:C0030286",
          "icd11.foundation:1726554290"
        ],
        "synonyms": [
          "disease of pancreas",
          "disease or disorder of pancreas",
          "disorder of pancreas",
          "pancreas disease",
          "pancreas disease or disorder",
          "pancreatic disorder",
          "disease, pancreatic",
          "diseases, pancreatic",
          "pancreatic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the pancreas. Representative examples of non-neoplastic disorders include pancreatitis and pancreatic insufficiency. Representative examples of neoplastic disorders include cystadenomas, carcinomas, lymphomas, and neuroendocrine neoplasms."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002356"
    }
  ],
  "children": [
    {
      "id": 3954,
      "label": "gastrin secretion abnormality",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4104
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13656",
          "ICD9:251.5",
          "MEDGEN:507382",
          "SCTID:47344007",
          "UMLS:C0000774"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0001770"
    },
    {
      "id": 4126,
      "label": "abnormality of glucagon secretion",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4104
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14427",
          "ICD9:251.4",
          "MEDGEN:509540",
          "SCTID:11178005",
          "UMLS:C0154191"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001962"
    },
    {
      "id": 4302,
      "label": "hyperinsulinism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4104,
        4915
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2018",
          "HP:0000842",
          "ICD9:251.1",
          "MEDGEN:43779",
          "MESH:D006946",
          "SCTID:83469008",
          "UMLS:C0020459",
          "icd11.foundation:224022886"
        ],
        "synonyms": [
          "hyperinsulinism",
          "hyperinsulinism (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Abnormally high levels of insulin in the blood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002177"
    },
    {
      "id": 4356,
      "label": "post-surgical hypoinsulinemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4104
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2181",
          "ICD9:251.3",
          "MEDGEN:509539",
          "SCTID:190437000",
          "UMLS:C0154190"
        ],
        "synonyms": [
          "postsurgical hypoinsulinemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0002239"
    },
    {
      "id": 5899,
      "label": "pancreatic cholera",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4104
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6977",
          "ICD9:259.3",
          "MEDGEN:39692",
          "NCIT:C3488",
          "SCTID:39998009",
          "UMLS:C0086768"
        ],
        "synonyms": [
          "Verner Morrison syndrome",
          "WDHA syndrome",
          "WDHH",
          "islet cell WDHA syndrome",
          "pancreatic WDHA syndrome",
          "watery diarrhea syndrome",
          "watery diarrhea with hypokalemic alkalosis",
          "watery diarrhea, hypokalemia, and achlorhydria syndrome",
          "watery diarrhoea syndrome",
          "watery diarrhoea with hypokalemic alkalosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare syndrome characterized by severe watery diarrhea, hypokalemia, and achlorhydria. It is caused by the oversecretion of vasoactive intestinal peptide from the pancreatic islet cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004058"
    },
    {
      "id": 6752,
      "label": "diabetes mellitus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4104,
        4915
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9351",
          "EFO:0000400",
          "HP:0000819",
          "ICD10CM:E08-E13",
          "ICD10WHO:E10-E14",
          "ICD9:250",
          "MEDGEN:8350",
          "MESH:D003920",
          "NANDO:2100157",
          "NANDO:2100158",
          "NCIT:C2985",
          "SCTID:73211009",
          "UMLS:C0011849",
          "icd11.foundation:465177735"
        ],
        "synonyms": [
          "DM",
          "diabetes",
          "diabetes mellitus",
          "diabetes mellitus (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005015"
    },
    {
      "id": 6896,
      "label": "aggressive insulitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4104,
        6778
      ],
      "type_id": 0,
      "properties": {
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Insulitis is an inflammatory infiltration of the islets of Langerhans found especially in young patients with recent onset type 1 diabetes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005175"
    },
    {
      "id": 6897,
      "label": "benign insulitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4104,
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "PMID:20545565",
          "Wikipedia:Insulitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign form of insulitis which is an inflammation of the islets of Langerhans of the pancreas. The pancreas and in some cases the Pancreatic β-cells become infiltrated by polymorphonuclear leukocytes and infiltrated by mononuclear cells, leading to inflammation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005176"
    },
    {
      "id": 7431,
      "label": "pancreatic neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4104,
        20285,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1799",
          "EFO:0007331",
          "GARD:0022052",
          "ICDO:8150/1",
          "MEDGEN:1848937",
          "NCIT:C27031",
          "Orphanet:506052",
          "SCTID:254611009",
          "UMLS:C5848399",
          "icd11.foundation:1421495979"
        ],
        "synonyms": [
          "PNEN",
          "endocrine pancreas neoplasm",
          "endocrine pancreas neoplasm (disease)",
          "endocrine pancreas tumor",
          "endocrine pancreas tumour",
          "neoplasm of endocrine pancreas",
          "pancreatic NEN",
          "pancreatic endocrine neoplasm",
          "pancreatic neuroendocrine neoplasm",
          "tumor of endocrine pancreas",
          "tumour of endocrine pancreas",
          "Islet cell tumors",
          "Islet cell tumours",
          "endocrine pancreas cancer",
          "islet cell neoplasm",
          "islet cell tumor",
          "islet cell tumour",
          "malignant pancreatic endocrine tumor",
          "malignant pancreatic endocrine tumour",
          "Islet of Langerhans tumor",
          "Islet of Langerhans tumour",
          "neuroendocrine neoplasm of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the pancreas. It includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine carcinomas (high grade)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005815"
    },
    {
      "id": 9170,
      "label": "islet cell adenomatosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4104,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:293643",
          "MESH:C563258",
          "NCIT:C4375",
          "OMIM:147630",
          "SCTID:274944000",
          "UMLS:C1578917"
        ],
        "synonyms": [
          "islet cell adenomatosis",
          "INSDM",
          "INSULINOMATOSIS and diabetes mellitus",
          "Insulinomatosis and diabetes mellitus",
          "nesidioblastosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sporadic or inherited disorder characterized by the focal or diffuse proliferation of the cells of the islets of Langerhans in the pancreas. It results in hyperinsulinemia and hypoglycemia."
      },
      "child_count": 2,
      "reference_id": "MONDO:0007834"
    },
    {
      "id": 13568,
      "label": "insulin-resistance syndrome type A",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4104,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0003008",
          "MEDGEN:501111",
          "MESH:C562710",
          "NCIT:C131836",
          "OMIM:610549",
          "Orphanet:2297",
          "UMLS:C0342278",
          "icd11.foundation:343459534"
        ],
        "synonyms": [
          "insulin resistant diabetes mellitus with acanthosis nigricans and hyperandrogenism",
          "type A insulin resistance syndrome",
          "Iran, type a",
          "diabetes mellitus, insulin-resistant, with acanthosis nigricans",
          "diabetes mellitus, insulin-resistant, with acanthosis nigricans, type a",
          "insulin receptor, defect in, with insulin-resistant diabetes mellitus and acanthosis nigricans",
          "insulin-resistant acanthosis nigricans, type A"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Type A insulin-resistance syndrome belongs to the group of extreme insulin-resistance syndromes (which includes leprechaunism, the lipodystrophies, Rabson-Mendenhall syndrome and type B insulin resistance syndrome) and is characterized by the triad of hyperinsulinemia, acanthosis nigricans (skin lesions associated with insulin resistance), and signs of hyperandrogenism in females without lipodystrophy and who are not overweight."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012520"
    },
    {
      "id": 16975,
      "label": "insulin-resistance syndrome type B",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4104
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0003009",
          "MEDGEN:574967",
          "Orphanet:2298",
          "UMLS:C0342337",
          "icd11.foundation:408487090"
        ],
        "synonyms": [
          "insulin-resistance type B"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Type B insulin-resistance syndrome belongs to the group of extreme insulin-resistance syndromes (which includes leprechaunism, the lipodystrophies, Rabson-Mendenhall syndrome, and type A insulin resistance syndrome) and occurs in the context of immune dysfunction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016464"
    }
  ],
  "roots": [
    {
      "id": 4455,
      "label": "pancreas disorder"
    }
  ]
}