{
  "id": 4158,
  "label": "idiopathic pulmonary arterial hypertension",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0001999",
  "properties": {
    "xrefs": [
      "DOID:14557",
      "GARD:0027594",
      "ICD10CM:I27.0",
      "ICD9:416.0",
      "MEDGEN:468368",
      "MedDRA:10065151",
      "Orphanet:275766",
      "SCTID:697898008",
      "UMLS:C3203102",
      "icd11.foundation:265520344"
    ],
    "synonyms": [
      "IPAH",
      "idiopathic pulmonary arterial hypertension",
      "primary pulmonary arterial hypertension",
      "primary pulmonary hypertension"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A sporadic form of pulmonary arterial hypertension (PAH) characterized by elevated pulmonary arterial resistance leading to right heart failure. IPAH is progressive and potentially fatal and not associated with an underlying condition or family history of PAH. The etiology is unknown."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3703,
      "label": "chronic pulmonary heart disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6388
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12326",
          "ICD9:416.8",
          "ICD9:416.9",
          "MEDGEN:116042",
          "NANDO:2200299",
          "NCIT:C34478",
          "SCTID:87837008",
          "UMLS:C0238074"
        ],
        "synonyms": [
          "Cor pulmonale"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Heart disease which occurs as a result of a primary pulmonary disease. Cor pulmonale most often manifests as right ventricular hypertrophy; it can also lead to right ventricular failure."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001493"
    },
    {
      "id": 16614,
      "label": "pulmonary arterial hypertension",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001361",
          "GARD:0007501",
          "MEDGEN:425404",
          "MESH:D000081029",
          "MedDRA:10064911",
          "NANDO:1200425",
          "NANDO:2100103",
          "NANDO:2200298",
          "NORD:1634",
          "Orphanet:182090",
          "Orphanet:422",
          "SCTID:11399002",
          "UMLS:C2973725",
          "icd11.foundation:1931148955"
        ],
        "synonyms": [
          "PAH",
          "pulmonary arterial hypertension",
          "PAH with overt features of venous/capillaries involvement",
          "PVOD/PCH",
          "PPH",
          "idiopathic pulmonary hypertension"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Pulmonary arterial hypertension (PAH) is a group of diseases characterized by mean pulmonary artery pressure >20 mmHg and elevated pulmonary arterial resistance leading to right heart failure. PAH is progressive and potentially fatal. PAH may be idiopathic and/ or familial, have overt features of venous/capillary involvement (pulmonary veno-occlusive disease, PVOD/pulmonary capillary hemangiomatosis, PCH), induced by drug or toxin (drug-or toxin-induced PAH), or associated with other diseases like congenital heart disease, connective tissue disease, HIV, schistosomiasis, portal hypertension (PAH associated with other disease)."
      },
      "child_count": 5,
      "reference_id": "MONDO:0015924"
    },
    {
      "id": 24405,
      "label": "idiopathic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29381
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:548250",
          "UMLS:C0277553"
        ],
        "synonyms": [
          "idiopathic disorder"
        ],
        "definition": "A disease or disorder for which the cause is of uncertain or unknown."
      },
      "child_count": 79,
      "reference_id": "MONDO:0700007"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3703,
      "label": "chronic pulmonary heart disease"
    },
    {
      "id": 16614,
      "label": "pulmonary arterial hypertension"
    },
    {
      "id": 24405,
      "label": "idiopathic disease"
    }
  ]
}