{
  "id": 4167,
  "label": "lymphangioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002013",
  "properties": {
    "xrefs": [
      "DOID:1475",
      "ICD9:228.1",
      "ICDO:9170/0",
      "MEDGEN:6153",
      "MESH:D008202",
      "NANDO:2201032",
      "NCIT:C8965",
      "Orphanet:2415",
      "SCTID:254836000",
      "SCTID:400178008",
      "UMLS:C0024221"
    ],
    "synonyms": [
      "benign lymphangioma (morphologic abnormality)",
      "lymphangioma",
      "lymphangioma, benign",
      "congenital lymphangioma",
      "LM"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A benign lesion composed of dilated lymphatic channels. Painless swelling is the usual clinical manifestation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 3034,
      "label": "cardiovascular organ benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        21585
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060091",
          "MEDGEN:1843462",
          "UMLS:C0848083"
        ],
        "synonyms": [
          "cardiovascular system benign neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the cardiovascular system."
      },
      "child_count": 18,
      "reference_id": "MONDO:0000629"
    },
    {
      "id": 22949,
      "label": "lymphatic vessel neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        7447,
        21330
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1857625",
          "NCIT:C3723",
          "UMLS:C2103272"
        ],
        "synonyms": [
          "lymph vessel neoplasm",
          "lymph vessel tumor",
          "lymph vessel tumour",
          "lymphatic vessel neoplasm",
          "lymphatic vessel tumor",
          "lymphatic vessel tumour",
          "neoplasm of lymph vessel",
          "neoplasm of lymphatic vessel",
          "neoplasm of the lymph vessel",
          "neoplasm of the lymphatic vessel",
          "tumor of lymph vessel",
          "tumor of lymphatic vessel",
          "tumor of the lymph vessel",
          "tumor of the lymphatic vessel",
          "tumour of lymph vessel",
          "tumour of lymphatic vessel",
          "tumour of the lymph vessel",
          "tumour of the lymphatic vessel"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from the lymphatic vessels."
      },
      "child_count": 3,
      "reference_id": "MONDO:0036870"
    }
  ],
  "children": [
    {
      "id": 3345,
      "label": "colonic lymphangioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167,
        4392
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10657",
          "GARD:0022878",
          "MEDGEN:232381",
          "NCIT:C5500",
          "UMLS:C1333094"
        ],
        "synonyms": [
          "colon lymphangioma",
          "colonic lymphangioma",
          "lymphangioma of colon",
          "lymphangioma of the colon"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A lymphangioma arising from the colon."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001093"
    },
    {
      "id": 4378,
      "label": "capillary lymphangioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3777,
        4167,
        21322
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2286",
          "GARD:0023102",
          "MEDGEN:569678",
          "SCTID:445492005",
          "UMLS:C0334543"
        ],
        "synonyms": [
          "capillary lymphangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A lymphangioma that involves the capillary."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002262"
    },
    {
      "id": 8285,
      "label": "lymphangioendothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001026",
          "GARD:0024485",
          "MEDGEN:7411",
          "NCIT:C3203",
          "SCTID:403975006",
          "UMLS:C0024217"
        ],
        "synonyms": [
          "acquired progressive lymphangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A lymphangioma characterized by the presence of collagen bundle formation. It has an indolent clinical course and may be associated with skin plaques."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006841"
    },
    {
      "id": 8805,
      "label": "Gorham-Stout disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167,
        5126,
        7203
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006542",
          "ICD9:733.99",
          "MEDGEN:45248",
          "MedDRA:10071283",
          "NANDO:1200878",
          "NANDO:1200880",
          "NORD:1200",
          "OMIM:123880",
          "Orphanet:73",
          "SCTID:1515008",
          "UMLS:C0029438",
          "icd11.foundation:1318015458"
        ],
        "synonyms": [
          "Gorham disease",
          "Gorham syndrome",
          "Gorham-Stout disease",
          "idiopathic massive osteolysis",
          "progressive massive osteolysis",
          "vanishing bone disease",
          "cystic angiomatosis of bone diffuse",
          "cystic angiomatosis of bone, diffuse",
          "osteolysis massive",
          "osteolysis, massive"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Gorham-Stout disease (GSD) is a rare disease of massive osteolysis associated with proliferation and dilation of lymphatic vessels. GSD may affect any bone in the body and can be monostotic or polyostotic. Symptoms at presentation are dependent upon the location(s) of the disease; the most common symptom is localized pain. The disease may be discovered after a pathological fracture."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007414"
    },
    {
      "id": 10971,
      "label": "cystic hygroma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3081",
          "EFO:1000888",
          "GARD:0006234",
          "ICDO:9173/0",
          "MEDGEN:60195",
          "MESH:D018191",
          "MedDRA:10058949",
          "NCIT:C3724",
          "OMIM:257350",
          "Orphanet:79486",
          "SCTID:399882002",
          "UMLS:C0206620"
        ],
        "synonyms": [
          "cystic hygroma",
          "cystic lymphangioma",
          "hygroma",
          "cystic hygroma, fetal",
          "cystic hygroma, foetal",
          "macrocystic lymphatic malformation",
          "nuchal bleb, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A benign lymphatic neoplasm usually arising from the neck and characterized by cystic dilation of the lymphatic vessels."
      },
      "child_count": 1,
      "reference_id": "MONDO:0009761"
    },
    {
      "id": 14359,
      "label": "lymphedema-posterior choanal atresia syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016898",
          "MEDGEN:462225",
          "OMIM:613611",
          "Orphanet:99141",
          "UMLS:C3150875"
        ],
        "synonyms": [
          "CATLPH",
          "choanal atresia and lymphedema"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013324"
    },
    {
      "id": 16260,
      "label": "diffuse lymphatic malformation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081031",
          "GARD:0019961",
          "MEDGEN:825766",
          "NANDO:1200879",
          "NANDO:2201033",
          "Orphanet:141209",
          "SCTID:703298001",
          "UMLS:C3839921",
          "icd11.foundation:913891613"
        ],
        "synonyms": [
          "GLA",
          "Gla",
          "diffuse lymphangioma",
          "diffuse lymphangiomatosis",
          "disseminated lymphangioma",
          "disseminated lymphangiomatosis",
          "disseminated lymphatic malformation",
          "generalised lymphatic anomaly",
          "generalized lymphatic anomaly"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A rare developmental defect during embryogenesis characterized by multifocal dilated lymphatic vessels involving multiple organs and tissues. Patients mostly present in infancy and childhood. Clinical course and prognosis depend on the affected sites and extent of the condition, deterioration of lung function being a major cause of morbidity and mortality."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015408"
    },
    {
      "id": 18700,
      "label": "mixed cystic lymphatic malformation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021912",
          "MEDGEN:1805965",
          "Orphanet:458792",
          "UMLS:C5680000"
        ],
        "synonyms": [
          "mixed cystic lymphangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018717"
    },
    {
      "id": 18705,
      "label": "multifocal lymphangioendotheliomatosis-thrombocytopenia syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010467",
          "MEDGEN:1804470",
          "NCIT:C60672",
          "Orphanet:464321",
          "UMLS:C5575322"
        ],
        "synonyms": [
          "DKFZp434L132",
          "MALT1 wt allele",
          "MLT",
          "MLT1",
          "cutaneovisceral angiomatosis-thrombocytopenia syndrome",
          "mucosa associated lymphoid tissue lymphoma translocation Gene 1 wt allele",
          "multifocal lymphangioendotheliomatosis with thrombocytopenia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Human MALT1 wild-type allele is located in the vicinity of 18q21 and is approximately 79 kb in length. This allele, which encodes mucosa associated lymphoid tissue lymphoma translocation gene 1 protein, plays a role in the modulation of the nuclear factor kappa B complex signaling cascade. The gene is involved in a chromosomal translocation t(11;18)(q21;q21) with the BIRC2 gene in mucosa-associated lymphoid tissue lymphomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018735"
    },
    {
      "id": 19169,
      "label": "macrocystic lymphatic malformation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006010",
          "MEDGEN:104729",
          "NANDO:1200881",
          "NCIT:C53316",
          "Orphanet:79489",
          "UMLS:C0205828",
          "icd11.foundation:1525487462"
        ],
        "synonyms": [
          "cavernous lymphangioma",
          "cavernous lymphatic malformation",
          "macrocystic lymphangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A lymphangioma characterized by the presence of thin-walled cavernous lymphatic spaces."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019328"
    },
    {
      "id": 19170,
      "label": "microcystic lymphatic malformation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013020",
          "MEDGEN:1843242",
          "NCIT:C45485",
          "Orphanet:79490",
          "UMLS:C4738056",
          "icd11.foundation:1796778763"
        ],
        "synonyms": [
          "capillary lymphatic malformation",
          "cutaneous lymphangioma circumscriptum",
          "microcystic infiltrating lymphatic malformation",
          "microcystic lymphangioma",
          "superficial lymphangioma",
          "superficial lymphatic malformation",
          "capillary lymphangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019329"
    },
    {
      "id": 21574,
      "label": "skin lymphangioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4167,
        20564
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025454",
          "MEDGEN:232399",
          "NCIT:C27509",
          "UMLS:C1333176"
        ],
        "synonyms": [
          "cutaneous lymphangioma",
          "skin lymphangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A lymphangioma arising from the skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024673"
    }
  ],
  "roots": [
    {
      "id": 3034,
      "label": "cardiovascular organ benign neoplasm"
    },
    {
      "id": 22949,
      "label": "lymphatic vessel neoplasm"
    }
  ]
}