{
  "id": 4213,
  "label": "ventricular septal defect",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002070",
  "properties": {
    "xrefs": [
      "DOID:1657",
      "HP:0001629",
      "ICD10CM:Q21.0",
      "ICD9:745.4",
      "MEDGEN:42366",
      "MESH:D006345",
      "NANDO:2100087",
      "NANDO:2200270",
      "NCIT:C84506",
      "OMIMPS:614429",
      "Orphanet:1480",
      "SCTID:30288003",
      "UMLS:C0018818",
      "icd11.foundation:668140715"
    ],
    "synonyms": [
      "VSD",
      "interventricular communication",
      "interventricular septal defect",
      "ventricular septal defect",
      "ventricular septal defect (disease)",
      "heart septal defects, ventricular",
      "ventricular septal defects"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "The presence of a defect (opening) in the septum that separates the two ventricles of the heart. It can be congenital or acquired."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4221,
      "label": "heart septal defect",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7116
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1681",
          "ICD9:745.8",
          "ICD9:745.9",
          "MEDGEN:6752",
          "MESH:D006343",
          "NCIT:C84482",
          "SCTID:253273004",
          "UMLS:C0018816"
        ],
        "synonyms": [
          "Cardiac septal defects",
          "congenital septal defect",
          "holes in the heart"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A congenital disorder characterized by the presence of an abnormal communication between the atria or the ventricles of the heart due to defects in the cardiac septum."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002078"
    },
    {
      "id": 24272,
      "label": "cardiogenetic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6967
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "hereditary heart disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions, with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology that are characterized by abnormalities in the cardiovascular system."
      },
      "child_count": 146,
      "reference_id": "MONDO:0100547"
    }
  ],
  "children": [
    {
      "id": 14764,
      "label": "ventricular septal defect 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4213,
        23767
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:482407",
          "OMIM:614429",
          "UMLS:C3280777"
        ],
        "synonyms": [
          "GATA4 ventricular septal defect (disease)",
          "ventricular septal defect (disease) caused by mutation in GATA4",
          "ventricular septal defect 1",
          "ventricular septal defect type 1",
          "VSD1"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any ventricular septal defect in which the cause of the disease is a mutation in the GATA4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013746"
    },
    {
      "id": 14766,
      "label": "ventricular septal defect 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4213
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:482413",
          "OMIM:614431",
          "UMLS:C3280783"
        ],
        "synonyms": [
          "CITED2 ventricular septal defect (disease)",
          "ventricular septal defect (disease) caused by mutation in CITED2",
          "ventricular septal defect 2",
          "ventricular septal defect type 2",
          "VSD2"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any ventricular septal defect in which the cause of the disease is a mutation in the CITED2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013748"
    },
    {
      "id": 14767,
      "label": "ventricular septal defect 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4213
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:482415",
          "OMIM:614432",
          "UMLS:C3280785"
        ],
        "synonyms": [
          "NKX2-5 ventricular septal defect (disease)",
          "ventricular septal defect (disease) caused by mutation in NKX2-5",
          "ventricular septal defect 3",
          "ventricular septal defect type 3",
          "VSD3"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any ventricular septal defect in which the cause of the disease is a mutation in the NKX2-5 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013749"
    },
    {
      "id": 18249,
      "label": "double outlet right ventricle",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4213,
        17072
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6406",
          "GARD:0001908",
          "ICD10CM:Q20.1",
          "MEDGEN:41649",
          "MESH:D004310",
          "MedDRA:10013611",
          "NANDO:1200710",
          "NANDO:2100076",
          "NANDO:2200256",
          "NCIT:C98916",
          "Orphanet:3426",
          "SCTID:204299009",
          "UMLS:C0013069",
          "icd11.foundation:141717788"
        ],
        "synonyms": [
          "DORV",
          "double outlet right ventricle"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Double outlet right ventricle (DORV) is a rare cono-truncal anomaly in which both the aorta and pulmonary artery originate, either entirely or predominantly, from the morphologic right ventricle."
      },
      "child_count": 10,
      "reference_id": "MONDO:0018089"
    },
    {
      "id": 24817,
      "label": "anterior deviation infundibular septum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4213
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:756812",
          "SCTID:448619007",
          "UMLS:C3164404"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800107"
    }
  ],
  "roots": [
    {
      "id": 4221,
      "label": "heart septal defect"
    },
    {
      "id": 24272,
      "label": "cardiogenetic disease"
    }
  ]
}