{
  "id": 4221,
  "label": "heart septal defect",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002078",
  "properties": {
    "xrefs": [
      "DOID:1681",
      "ICD9:745.8",
      "ICD9:745.9",
      "MEDGEN:6752",
      "MESH:D006343",
      "NCIT:C84482",
      "SCTID:253273004",
      "UMLS:C0018816"
    ],
    "synonyms": [
      "Cardiac septal defects",
      "congenital septal defect",
      "holes in the heart"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A congenital disorder characterized by the presence of an abnormal communication between the atria or the ventricles of the heart due to defects in the cardiac septum."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 7116,
      "label": "congenital heart disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6967,
        21294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1682",
          "EFO:0005207",
          "ICD9:746.84",
          "ICD9:746.89",
          "ICD9:746.9",
          "MEDGEN:57501",
          "MESH:D006330",
          "NCIT:C95834",
          "SCTID:13213009",
          "UMLS:C0152021",
          "icd11.foundation:2004408087"
        ],
        "synonyms": [
          "heart malformation",
          "congenital anomaly of heart",
          "congenital heart defect",
          "congenital heart defects",
          "Abnormality, heart",
          "abnormalities, heart",
          "defect, congenital heart",
          "defects, congenital heart",
          "heart abnormalities",
          "heart abnormality",
          "heart defect, congenital",
          "heart, malformation Of"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and patent foramen ovale."
      },
      "child_count": 46,
      "reference_id": "MONDO:0005453"
    }
  ],
  "children": [
    {
      "id": 4213,
      "label": "ventricular septal defect",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4221,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1657",
          "HP:0001629",
          "ICD10CM:Q21.0",
          "ICD9:745.4",
          "MEDGEN:42366",
          "MESH:D006345",
          "NANDO:2100087",
          "NANDO:2200270",
          "NCIT:C84506",
          "OMIMPS:614429",
          "Orphanet:1480",
          "SCTID:30288003",
          "UMLS:C0018818",
          "icd11.foundation:668140715"
        ],
        "synonyms": [
          "VSD",
          "interventricular communication",
          "interventricular septal defect",
          "ventricular septal defect",
          "ventricular septal defect (disease)",
          "heart septal defects, ventricular",
          "ventricular septal defects"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "The presence of a defect (opening) in the septum that separates the two ventricles of the heart. It can be congenital or acquired."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002070"
    },
    {
      "id": 8134,
      "label": "atrial septal defect",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4221,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1882",
          "EFO:1000825",
          "ICD10CM:Q21.1",
          "MEDGEN:6753",
          "MESH:D006344",
          "MedDRA:10003664",
          "MedDRA:10019308",
          "MedDRA:10068864",
          "NANDO:2100085",
          "NCIT:C84473",
          "NORD:820",
          "OMIMPS:108800",
          "Orphanet:1478",
          "SCTID:253366007",
          "UMLS:C0018817",
          "icd11.foundation:1285985084"
        ],
        "synonyms": [
          "ASD",
          "Atrial Septal Defects",
          "atrial septal defect",
          "atrial septum defect",
          "auricular septal defect",
          "congenital atrial septal defect",
          "interatrial septal defect",
          "interauricular communication",
          "interatrial communication"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Interauricular communication is a congenital malformation characterized by a communication between the atrial chambers of the heart."
      },
      "child_count": 30,
      "reference_id": "MONDO:0006664"
    },
    {
      "id": 19775,
      "label": "familial atrioventricular septal defect",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4221,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050651",
          "GARD:0000802",
          "ICD10CM:Q21.2",
          "ICD9:745.6",
          "ICD9:745.60",
          "ICD9:745.69",
          "NCIT:C101029",
          "NORD:821",
          "OMIMPS:606215",
          "Orphanet:98722",
          "SCTID:15459006"
        ],
        "synonyms": [
          "Atrioventricular Septal Defect",
          "AV septal defect",
          "AVCD",
          "AVSD",
          "ECD",
          "atrioventricular canal defect",
          "atrioventricular septal defect",
          "common AV canal",
          "common atrioventricular canal",
          "endocardial cushion defect"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A spectrum of septal defects involving the atrial septum; ventricular septum; and the atrioventricular valves (tricuspid valve; bicuspid valve). These defects are due to incomplete growth and fusion of the endocardial cushions which are important in the formation of two atrioventricular canals, site of future atrioventricular valves."
      },
      "child_count": 12,
      "reference_id": "MONDO:0020290"
    }
  ],
  "roots": [
    {
      "id": 7116,
      "label": "congenital heart disease"
    }
  ]
}