{
  "id": 4246,
  "label": "pituitary cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002109",
  "properties": {
    "xrefs": [
      "DOID:1785",
      "EFO:0005578",
      "GARD:0023064",
      "ICD10CM:C75.1",
      "MEDGEN:96922",
      "NCIT:C4769",
      "SCTID:363482009",
      "UMLS:C0496842",
      "icd11.foundation:1130461249"
    ],
    "synonyms": [
      "pituitary gland neoplasm",
      "pituitary neoplasm",
      "cancer of pituitary gland",
      "malignant neoplasm of pituitary",
      "malignant neoplasm of pituitary gland",
      "malignant neoplasm of the pituitary",
      "malignant neoplasm of the pituitary gland",
      "malignant pituitary gland neoplasm",
      "malignant pituitary gland tumor",
      "malignant pituitary gland tumour",
      "malignant pituitary neoplasm",
      "malignant pituitary tumor",
      "malignant pituitary tumour",
      "malignant tumor of pituitary",
      "malignant tumor of pituitary gland",
      "malignant tumor of the pituitary",
      "malignant tumor of the pituitary gland",
      "malignant tumour of pituitary",
      "malignant tumour of pituitary gland",
      "malignant tumour of the pituitary",
      "malignant tumour of the pituitary gland",
      "pituitary cancer",
      "pituitary gland cancer",
      "pituitary neoplasms, malignant",
      "pituitary tumor, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A primary or metastatic malignant neoplasm affecting the pituitary gland. Representative examples include functioning or non-functioning carcinomas arising from the anterior lobe of the pituitary gland, chordomas, chondrosarcomas, and metastatic carcinomas from the breast, lung, and gastrointestinal tract."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4265,
      "label": "skull cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        7266,
        21561
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1863",
          "GARD:0023073",
          "MEDGEN:1662558",
          "NCIT:C155790",
          "UMLS:C2062986"
        ],
        "synonyms": [
          "cancer of skull",
          "malignant neoplasm of skull",
          "malignant skull neoplasm",
          "skull cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the skull."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002132"
    },
    {
      "id": 4279,
      "label": "reproductive system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:193",
          "MEDGEN:233668",
          "NCIT:C36076",
          "UMLS:C1334618"
        ],
        "synonyms": [
          "reproductive tumor",
          "reproductive tumour",
          "cancer of reproductive organ",
          "cancer of reproductive system",
          "malignant neoplasm of reproductive organ",
          "malignant neoplasm of reproductive system",
          "malignant reproductive organ neoplasm",
          "malignant reproductive system neoplasm",
          "reproductive organ cancer",
          "reproductive system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the reproductive organ"
      },
      "child_count": 16,
      "reference_id": "MONDO:0002149"
    },
    {
      "id": 5646,
      "label": "thalamic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4814,
        5067
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6098",
          "GARD:0027647",
          "MEDGEN:83429",
          "NCIT:C4576",
          "SCTID:188287005",
          "UMLS:C0346902",
          "icd11.foundation:610018988"
        ],
        "synonyms": [
          "cancer of dorsal plus ventral thalamus",
          "dorsal plus ventral thalamus cancer",
          "malignant dorsal plus ventral thalamus neoplasm",
          "malignant neoplasm of dorsal plus ventral thalamus",
          "malignant neoplasm of thalamus",
          "malignant neoplasm of the thalamus",
          "malignant thalamic neoplasm",
          "malignant thalamic neoplasms",
          "malignant thalamic tumor",
          "malignant thalamic tumors",
          "malignant thalamic tumour",
          "malignant thalamic tumours",
          "malignant thalamus neoplasm",
          "malignant thalamus neoplasms",
          "malignant thalamus tumor",
          "malignant thalamus tumors",
          "malignant thalamus tumour",
          "malignant thalamus tumours",
          "malignant tumor of thalamus",
          "malignant tumor of the thalamus",
          "malignant tumour of thalamus",
          "malignant tumour of the thalamus",
          "tumour of thalamus",
          "thalamic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A cancer involving a dorsal plus ventral thalamus."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003766"
    },
    {
      "id": 17888,
      "label": "pituitary tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        4759,
        5314,
        7638,
        8247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021253",
          "ICD9:239.7",
          "MEDGEN:19326",
          "NCIT:C3330",
          "Orphanet:304055",
          "SCTID:127024001",
          "UMLS:C0032019"
        ],
        "synonyms": [
          "neoplasm of pituitary",
          "neoplasm of pituitary gland",
          "neoplasm of the pituitary",
          "neoplasm of the pituitary gland",
          "pituitary gland neoplasm",
          "pituitary gland tumor",
          "pituitary gland tumour",
          "pituitary neoplasm",
          "pituitary tumor",
          "tumor of pituitary",
          "tumor of pituitary gland",
          "tumor of the pituitary",
          "tumor of the pituitary gland",
          "tumour of pituitary",
          "tumour of pituitary gland",
          "tumour of the pituitary",
          "tumour of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland."
      },
      "child_count": 45,
      "reference_id": "MONDO:0017611"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:170",
          "ICD9:194.9",
          "MEDGEN:56319",
          "MESH:D004701",
          "NCIT:C3575",
          "UMLS:C0153658"
        ],
        "synonyms": [
          "endocrine neoplasm",
          "Endocrine tumour",
          "cancer of endocrine gland",
          "endocrine cancer",
          "endocrine gland cancer",
          "endocrine neoplasm, malignant",
          "malignant endocrine gland neoplasm",
          "malignant endocrine gland tumor",
          "malignant endocrine gland tumour",
          "malignant endocrine neoplasm",
          "malignant endocrine tumor",
          "malignant endocrine tumour",
          "malignant neoplasm of endocrine gland",
          "malignant neoplasm of the endocrine gland",
          "malignant tumor of endocrine gland",
          "malignant tumor of the endocrine gland",
          "malignant tumour of the endocrine gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0021069"
    }
  ],
  "children": [
    {
      "id": 5697,
      "label": "growth hormone-producing pituitary gland carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4185,
        4246,
        4505,
        19647
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6256",
          "GARD:0023687",
          "MEDGEN:277331",
          "NCIT:C5963",
          "UMLS:C1334587"
        ],
        "synonyms": [
          "Growth hormone producing pituitary gland carcinoma",
          "Growth hormone-producing pituitary gland carcinoma",
          "malignant Growth hormone producing neoplasm of pituitary",
          "malignant Growth hormone producing neoplasm of pituitary gland",
          "malignant Growth hormone producing neoplasm of the pituitary",
          "malignant Growth hormone producing neoplasm of the pituitary gland",
          "malignant Growth hormone producing pituitary gland neoplasm",
          "malignant Growth hormone producing pituitary gland tumor",
          "malignant Growth hormone producing pituitary gland tumour",
          "malignant Growth hormone producing pituitary neoplasm",
          "malignant Growth hormone producing pituitary tumor",
          "malignant Growth hormone producing pituitary tumour",
          "malignant Growth hormone producing tumor",
          "malignant Growth hormone producing tumor of pituitary",
          "malignant Growth hormone producing tumor of pituitary gland",
          "malignant Growth hormone producing tumor of the pituitary",
          "malignant Growth hormone producing tumor of the pituitary gland",
          "malignant Growth hormone producing tumour",
          "malignant Growth hormone producing tumour of pituitary",
          "malignant Growth hormone producing tumour of pituitary gland",
          "malignant Growth hormone producing tumour of the pituitary",
          "malignant Growth hormone producing tumour of the pituitary gland",
          "malignant Growth hormone secreting neoplasm of pituitary",
          "malignant Growth hormone secreting neoplasm of pituitary gland",
          "malignant Growth hormone secreting neoplasm of the pituitary",
          "malignant Growth hormone secreting neoplasm of the pituitary gland",
          "malignant Growth hormone secreting pituitary gland neoplasm",
          "malignant Growth hormone secreting pituitary gland tumor",
          "malignant Growth hormone secreting pituitary gland tumour",
          "malignant Growth hormone secreting pituitary neoplasm",
          "malignant Growth hormone secreting pituitary tumor",
          "malignant Growth hormone secreting pituitary tumour",
          "malignant Growth hormone secreting tumor of pituitary",
          "malignant Growth hormone secreting tumor of pituitary gland",
          "malignant Growth hormone secreting tumor of the pituitary",
          "malignant Growth hormone secreting tumor of the pituitary gland",
          "malignant Growth hormone secreting tumour of pituitary",
          "malignant Growth hormone secreting tumour of pituitary gland",
          "malignant Growth hormone secreting tumour of the pituitary",
          "malignant Growth hormone secreting tumour of the pituitary gland",
          "malignant Somatotrophinoma of pituitary",
          "malignant Somatotrophinoma of pituitary gland",
          "malignant Somatotrophinoma of the pituitary gland",
          "malignant pituitary Somatotrophinoma",
          "malignant pituitary gland Somatotrophinoma",
          "malignant pituitary gland somatotropinoma",
          "malignant pituitary somatotropinoma",
          "malignant somatotropinoma of pituitary",
          "malignant somatotropinoma of pituitary gland",
          "malignant somatotropinoma of the pituitary",
          "malignant somatotropinoma of the pituitary gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces growth hormone. It may be associated with acromegaly."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003828"
    },
    {
      "id": 7895,
      "label": "pituicytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4246,
        5133,
        5202,
        17149
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081280",
          "EFO:1000477",
          "GARD:0020711",
          "ICD9:237.0",
          "ICDO:9432/1",
          "MEDGEN:458776",
          "NCIT:C94524",
          "ONCOTREE:PTCY",
          "Orphanet:251623",
          "SCTID:608817003",
          "UMLS:C2986550"
        ],
        "synonyms": [
          "pituicytoma",
          "pituicytoma (WHO grade I)",
          "posterior pituitary astrocytoma",
          "PTCY"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An extremely rare, WHO grade I, circumscribed and slow-growing tumor that arises from the neurohypophysis or infundibulum and described in adults. It is characterized by the presence of elongated, spindle-shaped neoplastic glial cells that form storiform patterns or interlacing fascicular arrangements. Signs and symptoms include visual disturbances, headache, amenorrhea, and decreased libido."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006372"
    },
    {
      "id": 17862,
      "label": "pituitary adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4185,
        4246,
        4505,
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4916",
          "GARD:0009371",
          "HP:0011763",
          "ICDO:8272/3",
          "MEDGEN:91096",
          "NCIT:C4536",
          "ONCOTREE:PTCA",
          "Orphanet:300385",
          "SCTID:254955001",
          "UMLS:C0346300"
        ],
        "synonyms": [
          "cancer of pituitary",
          "cancer of pituitary gland",
          "cancer of the pituitary",
          "cancer of the pituitary gland",
          "pituitary gland cancer",
          "carcinoma of pituitary",
          "carcinoma of pituitary gland",
          "carcinoma of the pituitary",
          "carcinoma of the pituitary gland",
          "pituitary adenocarcinoma (disease)",
          "pituitary carcinoma",
          "pituitary gland adenocarcinoma",
          "pituitary gland carcinoma",
          "PTCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly."
      },
      "child_count": 12,
      "reference_id": "MONDO:0017582"
    },
    {
      "id": 25249,
      "label": "pituitary blastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4246,
        7213
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081244",
          "GARD:0026634",
          "MEDGEN:1656462",
          "NCIT:C155304",
          "UMLS:C4743978"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pituitary cancer that is characterized by features of Cushing disease, with elevated blood ACTH levels and hypercortisolism arising within the fetal anterior pituitary and associated with DICER1 mutations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0858916"
    }
  ],
  "roots": [
    {
      "id": 4265,
      "label": "skull cancer"
    },
    {
      "id": 4279,
      "label": "reproductive system cancer"
    },
    {
      "id": 5646,
      "label": "thalamic cancer"
    },
    {
      "id": 17888,
      "label": "pituitary tumor"
    },
    {
      "id": 20310,
      "label": "malignant endocrine neoplasm"
    }
  ]
}