{ "id": 4253, "label": "urinary system disorder", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0002118", "properties": { "xrefs": [ "DOID:18", "EFO:0009690", "ICD9:V47.4", "MEDGEN:21791", "MESH:D014570", "NCIT:C3430", "SCTID:128606002", "UMLS:C0042075" ], "synonyms": [ "disease of renal system", "disease or disorder of renal system", "disease, urinary tract", "disease, urologic", "disease, urological", "diseases, urinary tract", "diseases, urologic", "diseases, urological", "disorder of renal system", "disorder of the urinary system", "disorder of urinary system", "renal system disease", "renal system disease or disorder", "urinary disease", "urinary system disorder", "urinary tract disease", "urinary tract diseases", "urinary tract disorder", "urologic disease", "urologic disorder", "urological disease", "urological diseases", "urological disorder", "urological disorders" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A disease involving the renal system." }, "isLeaf": false, "isRoot": false, "child_count": 20, "parents": [ { "id": 29379, "label": "disease by body system or component", "isLeaf": false, "isRoot": false, "parents": [ 24492 ], "type_id": 0, "properties": { "definition": "A grouping class for human diseases classified by the body system or anatomical component primarily affected." }, "child_count": 19, "reference_id": "MONDO:7770006" } ], "children": [ { "id": 4057, "label": "bacteriuria", "isLeaf": true, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "CSP:3045-9976", "DOID:1412", "HP:0012461", "MEDGEN:491", "MESH:D001437", "MedDRA:10004056", "UMLS:C0004659", "icd11.foundation:626563645" ], "synonyms": [ "bacteriuria", "bacteriuria (disease)" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "The presence of bacteria in the urine which is normally bacteria-free. These bacteria are from the urinary tract and are not contaminants of the surrounding tissues. Bacteriuria can be symptomatic or asymptomatic. Significant bacteriuria is an indicator of urinary tract infection." }, "child_count": 0, "reference_id": "MONDO:0001882" }, { "id": 4098, "label": "ureteral disorder", "isLeaf": false, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1426", "MEDGEN:98018", "MESH:D014515", "NCIT:C27148", "SCTID:128073008", "UMLS:C0403608" ], "synonyms": [ "disease of ureter", "disease or disorder of ureter", "disorder of ureter", "ureter disease", "ureter disease or disorder", "ureter disorder", "ureteric disease", "ureteric disorder" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A non-neoplastic or neoplastic disorder affecting the ureter." }, "child_count": 8, "reference_id": "MONDO:0001926" }, { "id": 4120, "label": "pyuria", "isLeaf": true, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1439", "HP:0012085", "MEDGEN:11078", "MESH:D011776", "UMLS:C0034359", "icd11.foundation:2000630356" ], "synonyms": [ "pus cells in urine", "pyuria", "pyuria (disease)" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "The presence of excessive white blood cells in the urine as determined by urinalysis." }, "child_count": 0, "reference_id": "MONDO:0001953" }, { "id": 5268, "label": "urinary tract obstruction", "isLeaf": false, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "DOID:5200", "EFO:0009571", "ICD9:599.6", "ICD9:599.60", "MEDGEN:64247", "NANDO:2200178", "NCIT:C3675", "SCTID:7163005", "UMLS:C0178879" ], "synonyms": [ "obstructive uropathy", "urinary obstruction" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "Blockage of the normal flow of contents of the urinary tract." }, "child_count": 2, "reference_id": "MONDO:0003330" }, { "id": 6006, "label": "urethral disorder", "isLeaf": false, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "DOID:732", "EFO:0009689", "MEDGEN:22569", "MESH:D014522", "NCIT:C26903", "SCTID:4985009", "UMLS:C0041969" ], "synonyms": [ "disease of urethra", "disease or disorder of urethra", "disorder of urethra", "urethra disease", "urethra disease or disorder", "urethra disorder" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A disease involving the urethra." }, "child_count": 10, "reference_id": "MONDO:0004184" }, { "id": 6948, "label": "kidney disorder", "isLeaf": false, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "DOID:557", "EFO:0003086", "ICD9:583.81", "MEDGEN:9635", "MESH:D007674", "NCIT:C3149", "SCTID:90708001", "UMLS:C0022658" ], "synonyms": [ "disease of kidney", "disease or disorder of kidney", "disorder of kidney", "kidney disease", "kidney disease or disorder", "kidney disorder", "renal disease", "renal disorder", "nephropathy" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A disease involving the kidney." }, "child_count": 57, "reference_id": "MONDO:0005240" }, { "id": 7612, "label": "urinary bladder disorder", "isLeaf": false, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "DOID:365", "EFO:1000018", "ICD9:596.8", "ICD9:596.9", "MEDGEN:2278", "MESH:D001745", "NCIT:C2900", "SCTID:42643001", "UMLS:C0005686" ], "synonyms": [ "bladder disease", "bladder disorder", "disease of urinary bladder", "disease or disorder of urinary bladder", "disorder of urinary bladder", "urinary bladder disease", "urinary bladder disease or disorder", "urinary bladder disorder" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A disease involving the urinary bladder." }, "child_count": 17, "reference_id": "MONDO:0006026" }, { "id": 9035, "label": "hyperglycinuria", "isLeaf": true, "isRoot": false, "parents": [ 4253, 5714 ], "type_id": 0, "properties": { "xrefs": [ "HP:0003108", "MEDGEN:107456", "MESH:C563009", "OMIM:138500", "UMLS:C0543541" ], "synonyms": [ "hyperglycinuria", "hyperglycinuria (disease)", "Iminoglycinuria type 2", "glycinuria with or without oxalate nephrolithiasis", "glycinuria with or without oxalate urolithiasis" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0007677" }, { "id": 9099, "label": "hypercalciuria, absorptive, 2", "isLeaf": true, "isRoot": false, "parents": [ 4253, 5714 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0018583", "ICD9:V18.19", "MEDGEN:137974", "MESH:C562790", "OMIM:143870", "SCTID:237886009", "UMLS:C0342639" ], "synonyms": [ "hypercalciuria, absorptive, 2", "hypercalciuria, absorptive, susceptibility to", "hypercalciuria, absorptive, type 2", "HCA2", "hypercalciuria, familial idiopathic" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0007748" }, { "id": 12884, "label": "hypercalciuria, absorptive, 1", "isLeaf": true, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0018584", "MEDGEN:375924", "MESH:C564600", "OMIM:607258", "UMLS:C1846573" ], "synonyms": [ "hypercalciuria, absorptive", "hypercalciuria, absorptive, 1", "hypercalciuria, absorptive, type 1", "Hca1" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0011802" }, { "id": 17043, "label": "megacystis-megaureter syndrome", "isLeaf": true, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0020638", "MEDGEN:609133", "Orphanet:238637", "SCTID:253904001", "UMLS:C0431752", "icd11.foundation:1872503107" ], "synonyms": [ "megaureter-megacystis syndrome" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "Megacystic-megaureter syndrome is an urinary tract malformation characterized by the presence of a massive primary non-obstructive vesicoureteral reflux and a large capacity, smooth, thin walled bladder due to the continual recycling of refluxed urine. Recurrent urinary infections are commonly associated with this condition." }, "child_count": 0, "reference_id": "MONDO:0016548" }, { "id": 17553, "label": "postorgasmic illness syndrome", "isLeaf": true, "isRoot": false, "parents": [ 4253, 5121 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0010809", "MEDGEN:1663577", "Orphanet:279947", "UMLS:C4749582", "icd11.foundation:1094271130" ], "synonyms": [ "POIS", "post orgasmic sick syndrome" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A rare condition in which a man develops flu-like symptoms after ejaculation (when semen is released from the penis). Specific symptoms can include extreme fatigue, weakness, feverishness or sweating, mood changes or irritability, memory or concentration problems, and/or a stuffy nose or itching eyes. Symptoms may occur within seconds, minutes, or a few hours after ejaculation. Most symptoms last for 2 to 7 days and go away on their own. The underlying cause of POIS is poorly understood. Some scientists believe it may be due to a semen allergy that causes an immediate hypersensitivity reaction. There is no standard treatment for POIS, but some men have been treated with SSRIs, antihistamines, and/or benzodiazepines. Hyposensitization therapy (decreasing the immune response by exposure to semen) reportedly improved symptoms in two men with POIS." }, "child_count": 0, "reference_id": "MONDO:0017213" }, { "id": 18575, "label": "congenital urachal anomaly", "isLeaf": false, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0021814", "MEDGEN:1433102", "Orphanet:435743", "UMLS:C1739100" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "Congenital urachal anomaly (CUA) describes a group of urachal remnants, found more frequently in males than females, that result from incomplete closure of the urachus (an embryological remnant of the allantois) during prenatal development, and that are usually asymptomatic (and found as an incidental finding on a radiological study) but can also present with umbilical discharge (in patent urachus or urachal sinus), infraumblical mass and pain, or with complications such as obstruction and infection. CUAs include patent urachus, urachal sinus, urachal cyst and urachal diverticulum." }, "child_count": 4, "reference_id": "MONDO:0018565" }, { "id": 20307, "label": "urinary system neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4253, 6798 ], "type_id": 0, "properties": { "xrefs": [ "ICD9:239.5", "MEDGEN:52949", "NCIT:C192666", "NCIT:C3431", "ONCOTREE:BLADDER", "SCTID:126879004", "UMLS:C0042076" ], "synonyms": [ "neoplasm of renal system", "neoplasm of the urinary system", "neoplasm of the urinary tract", "neoplasm of urinary system", "neoplasm of urinary tract", "renal system neoplasm", "renal system neoplasm (disease)", "renal system tumor", "renal system tumour", "tumor of renal system", "tumor of the urinary system", "tumor of the urinary tract", "tumor of urinary system", "tumor of urinary tract", "tumour of renal system", "tumour of the urinary system", "tumour of the urinary tract", "tumour of urinary system", "tumour of urinary tract", "urinary system neoplasm", "urinary system tumor", "urinary system tumour", "urinary tract neoplasm", "urinary tract tumor", "urinary tract tumour" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A benign or malignant, primary or metastatic neoplasm involving the urinary system. --2003" }, "child_count": 16, "reference_id": "MONDO:0021066" }, { "id": 21438, "label": "urothelial hyperplasia", "isLeaf": false, "isRoot": false, "parents": [ 4253, 6775 ], "type_id": 0, "properties": { "xrefs": [ "MEDGEN:234463", "NCIT:C27877", "UMLS:C1336895" ], "synonyms": [ "urothelial hyperplasia", "urothelium hyperplasia" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "Hyperplasia of the transitional epithelium of the urinary tract. Morphologically it is subdivided into flat and papillary hyperplasia. -- 2003" }, "child_count": 4, "reference_id": "MONDO:0024483" }, { "id": 21555, "label": "urolithiasis", "isLeaf": false, "isRoot": false, "parents": [ 4253 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080653", "ICD10CM:N20-N23", "ICD10CM:N21", "ICD10WHO:N20-N23", "MEDGEN:141536", "MESH:D052878", "NCIT:C114688", "SCTID:95566004", "UMLS:C0451641", "icd11.foundation:1746821938" ], "synonyms": [ "kidney stone", "calculus", "urinary stones", "urolithiasis" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "Stone(s) within the urinary tract." }, "child_count": 2, "reference_id": "MONDO:0024647" }, { "id": 24067, "label": "urinary tract infection", "isLeaf": false, "isRoot": false, "parents": [ 4253, 7200 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0080784", "EFO:0003103", "MEDGEN:52943", "MESH:D014552", "UMLS:C0042029" ], "synonyms": [ "urinary tract infection (disease)" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ] }, "child_count": 10, "reference_id": "MONDO:0100338" }, { "id": 24342, "label": "meningitis-retention syndrome", "isLeaf": true, "isRoot": false, "parents": [ 4253, 6799 ], "type_id": 0, "properties": { "synonyms": [ "MRS" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A neuro-urological condition characterized by aseptic meningitis, typically without any clear causative agent, associated with acute urinary retention. The typical symptoms and neurological signs of aseptic meningitis are usually mild or absent, so the predominant symptom often turns out to be isolated acute urinary retention. Although several cases are reported in the literature, MRS actual prevalence is underestimated. These factors make an early diagnosis of MRS difficult." }, "child_count": 0, "reference_id": "MONDO:0100623" }, { "id": 24650, "label": "paraneoplastic renal syndrome", "isLeaf": false, "isRoot": false, "parents": [ 4253, 20314 ], "type_id": 0, "properties": { "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" }, { "ref": "MONDO:0002254", "name": "syndromic disease" } ], "definition": "Paraneoplastic syndrome that involves the renal system." }, "child_count": 2, "reference_id": "MONDO:0700255" }, { "id": 24769, "label": "idiopathic hypercalciuria", "isLeaf": true, "isRoot": false, "parents": [ 4253, 24405 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0028042", "MEDGEN:1433919", "Orphanet:2197", "UMLS:C0543800" ], "categories": [ { "ref": "MONDO:0002118", "name": "urinary system disorder" } ], "definition": "A rare renal disease characterized by persistent excess urinary calcium excretion in the absence of an underlying systemic disease and hypercalcemia. The condition leads to an increased risk for the formation of kidney stones and nephrocalcinosis, as well as reduced bone mineral density with increased incidence of fractures in some patients." }, "child_count": 0, "reference_id": "MONDO:0700418" } ], "roots": [ { "id": 29379, "label": "disease by body system or component" } ] }