{
  "id": 4262,
  "label": "bone cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002129",
  "properties": {
    "xrefs": [
      "CSP:2019-1041",
      "DOID:184",
      "EFO:1000350",
      "GARD:0023070",
      "ICD9:170.9",
      "MEDGEN:79002",
      "MESH:D001859",
      "NCIT:C4016",
      "SCTID:428281000",
      "UMLS:C0279530"
    ],
    "synonyms": [
      "bone neoplasm",
      "bone tumor",
      "bone tumour",
      "osseous tumor",
      "osseous tumour",
      "bone cancer",
      "cancer of bone",
      "cancer of skeletal element",
      "cancer of the bone",
      "malignant bone neoplasm",
      "malignant bone tumor",
      "malignant neoplasm of bone",
      "malignant neoplasm of skeletal element",
      "malignant neoplasm of the bone",
      "malignant osseous neoplasm",
      "malignant osseous tumor",
      "malignant osseous tumour",
      "malignant skeletal element neoplasm",
      "malignant tumor of bone",
      "malignant tumor of the bone",
      "malignant tumour of bone",
      "malignant tumour of the bone",
      "osseous cancer",
      "skeletal element cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A primary or metastatic malignant neoplasm affecting the bone or articular cartilage."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 3041,
      "label": "musculoskeletal system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4222,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060100",
          "MEDGEN:1714562",
          "NCIT:C166357",
          "UMLS:C0036210"
        ],
        "synonyms": [
          "cancer of musculoskeletal system",
          "malignant musculoskeletal system neoplasm",
          "malignant neoplasm of musculoskeletal system",
          "musculoskeletal system cancer",
          "skeletal system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the musculoskeletal system"
      },
      "child_count": 22,
      "reference_id": "MONDO:0000637"
    },
    {
      "id": 18958,
      "label": "bone neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7061,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003820",
          "GARD:0018892",
          "ICD10CM:C40-C41",
          "MEDGEN:488993",
          "NCIT:C9343",
          "ONCOTREE:BONE",
          "Orphanet:68411",
          "UMLS:C2732838"
        ],
        "synonyms": [
          "bone neoplasm",
          "bone neoplasms",
          "bone tissue neoplasm",
          "bone tissue tumor",
          "bone tissue tumour",
          "bone tumor",
          "bone tumors",
          "bone tumour",
          "bone tumours",
          "neoplasm of bone",
          "neoplasm of bone tissue",
          "neoplasm of the bone",
          "osseous neoplasm",
          "osseous tumor",
          "osseous tumour",
          "tumor of bone",
          "tumor of bone tissue",
          "tumor of the bone",
          "tumour of bone",
          "tumour of bone tissue",
          "tumour of the bone",
          "primary bone cancer",
          "primary malignant neoplasm of bone",
          "rare bone tumor",
          "rare bone tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage."
      },
      "child_count": 40,
      "reference_id": "MONDO:0019060"
    }
  ],
  "children": [
    {
      "id": 2966,
      "label": "bone chondrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        10235
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050897",
          "GARD:0022784",
          "MEDGEN:756255",
          "UMLS:C3163843"
        ],
        "synonyms": [
          "bone tissue chondrosarcoma (disease)",
          "chondrosarcoma (disease) of bone tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A chondrosarcoma (disease) that involves the bone tissue."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000515"
    },
    {
      "id": 4265,
      "label": "skull cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        7266,
        21561
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1863",
          "GARD:0023073",
          "MEDGEN:1662558",
          "NCIT:C155790",
          "UMLS:C2062986"
        ],
        "synonyms": [
          "cancer of skull",
          "malignant neoplasm of skull",
          "malignant skull neoplasm",
          "skull cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the skull."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002132"
    },
    {
      "id": 4505,
      "label": "bone carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2762",
          "GARD:0023132"
        ],
        "synonyms": [
          "bone element carcinoma",
          "carcinoma of bone element"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A carcinoma that involves the bone element."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002415"
    },
    {
      "id": 4681,
      "label": "small cell osteogenic sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4262,
        8399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3377",
          "GARD:0023197",
          "ICDO:9185/3",
          "MEDGEN:83532",
          "NCIT:C4023",
          "ONCOTREE:SCOS",
          "UMLS:C0279622"
        ],
        "synonyms": [
          "small cell osteosarcoma",
          "SCOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of small cells and osteoid production. The prognosis is usually unfavorable."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002630"
    },
    {
      "id": 4984,
      "label": "peripheral primitive neuroectodermal tumor of bone",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4262,
        18390,
        20361
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4388",
          "GARD:0023312",
          "MEDGEN:163179",
          "NCIT:C8776",
          "UMLS:C0855009"
        ],
        "synonyms": [
          "bone peripheral neuroepithelioma",
          "bone tissue peripheral primitive neuroectodermal tumor",
          "bone tissue peripheral primitive neuroectodermal tumour",
          "osseous peripheral neuroepithelioma",
          "peripheral neuroectodermal tumor of bone",
          "peripheral neuroectodermal tumor of the bone",
          "peripheral neuroectodermal tumour of bone",
          "peripheral neuroectodermal tumour of the bone",
          "peripheral neuroepithelioma of bone",
          "peripheral neuroepithelioma of the bone",
          "peripheral primitive neuroectodermal tumor of bone",
          "peripheral primitive neuroectodermal tumor of bone tissue",
          "peripheral primitive neuroectodermal tumour of bone tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A small round cell tumor with neural differentiation arising from the bone. It may be associated with pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002981"
    },
    {
      "id": 5214,
      "label": "sternum cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        5215,
        20675
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5090",
          "GARD:0023432",
          "MEDGEN:277996",
          "NCIT:C8408",
          "UMLS:C1382025"
        ],
        "synonyms": [
          "neoplasm of sternum",
          "sternal tumour",
          "cancer of sternum",
          "malignant neoplasm of sternum",
          "malignant neoplasm of the sternum",
          "malignant sternal neoplasm",
          "malignant sternal tumor",
          "malignant sternal tumour",
          "malignant sternum neoplasm",
          "malignant tumor of sternum",
          "malignant tumor of the sternum",
          "malignant tumour of sternum",
          "malignant tumour of the sternum",
          "sternum cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the sternum"
      },
      "child_count": 3,
      "reference_id": "MONDO:0003273"
    },
    {
      "id": 5792,
      "label": "chest wall bone cancer",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4262,
        20502
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6579",
          "GARD:0023744",
          "MEDGEN:233148",
          "NCIT:C6724",
          "UMLS:C1334572"
        ],
        "synonyms": [
          "bone cancer of chest wall",
          "chest wall bone cancer",
          "malignant bone neoplasm of the chest wall",
          "malignant bone tumor of chest wall",
          "malignant bone tumor of the chest wall",
          "malignant bone tumour of chest wall",
          "malignant bone tumour of the chest wall",
          "malignant chest wall bone neoplasm",
          "malignant chest wall bone tumor",
          "malignant chest wall bone tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An uncommon malignant neoplasm that arises from the chest wall bones. Representative examples include chondrosarcoma, osteosarcoma, and Ewing sarcoma/peripheral primitive neuroectodermal tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003933"
    },
    {
      "id": 6187,
      "label": "adult extraskeletal osteosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4262,
        4672
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7827",
          "GARD:0023967",
          "MEDGEN:83016",
          "NCIT:C7925",
          "UMLS:C0278985"
        ],
        "synonyms": [
          "extraskeletal osteosarcoma",
          "adult extraosseous osteosarcoma",
          "adult extraskeletal osteosarcoma",
          "extraosseous osteosarcoma of adults"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An osteosarcoma arising from the soft tissue, and occurring in adults."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004374"
    },
    {
      "id": 18035,
      "label": "primary bone lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        17548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6759",
          "GARD:0021385",
          "MEDGEN:231451",
          "NCIT:C6620",
          "Orphanet:314684",
          "SCTID:766935007",
          "UMLS:C1332582"
        ],
        "synonyms": [
          "bone tissue lymphoma",
          "lymphoma of bone tissue",
          "primary lymphoma of bone",
          "primary lymphoma of the bone",
          "bone lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare non-Hodgkin lymphoma or even more rarely, a Hodgkin lymphoma that arises from the bone, without lymph node or other extranodal involvement. The femur, spine, and pelvic bones are the most commonly affected sites. The majority of patients present with bone pain in the affected area. A single bone or multiple skeletal sites may be involved. The prognosis is related to the cell type and the stage of the disease."
      },
      "child_count": 6,
      "reference_id": "MONDO:0017814"
    },
    {
      "id": 20297,
      "label": "bone sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        6816
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080639",
          "GARD:0020547",
          "ICD9:170.9",
          "MEDGEN:352831",
          "MedDRA:10006007",
          "NCIT:C9312",
          "Orphanet:223727",
          "SCTID:448710000",
          "UMLS:C1704327"
        ],
        "synonyms": [
          "bone sarcoma",
          "osseous sarcoma",
          "sarcoma of bone",
          "sarcoma of the bone",
          "skeletal sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A sarcoma that arises from the bone. Representative examples are osteosarcoma and chondrosarcoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0021054"
    },
    {
      "id": 20376,
      "label": "bone marrow cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        4262,
        7055
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025293",
          "MEDGEN:438070",
          "NCIT:C35501",
          "UMLS:C2703042"
        ],
        "synonyms": [
          "bone marrow cancer",
          "cancer of bone marrow",
          "malignant bone marrow neoplasm",
          "malignant bone marrow tumor",
          "malignant bone marrow tumour",
          "malignant neoplasm of bone marrow"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). --2003"
      },
      "child_count": 3,
      "reference_id": "MONDO:0021138"
    },
    {
      "id": 21344,
      "label": "cancer affecting bone of limb skeleton",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025387",
          "ICD10CM:C40",
          "MEDGEN:1843503",
          "UMLS:C0494152"
        ],
        "synonyms": [
          "cancer of limb bone",
          "limb bone cancer",
          "malignant limb bone neoplasm",
          "malignant neoplasm of limb bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A cancer that involves the limb bone."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024311"
    }
  ],
  "roots": [
    {
      "id": 3041,
      "label": "musculoskeletal system cancer"
    },
    {
      "id": 18958,
      "label": "bone neoplasm"
    }
  ]
}