{
  "id": 4265,
  "label": "skull cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002132",
  "properties": {
    "xrefs": [
      "DOID:1863",
      "GARD:0023073",
      "MEDGEN:1662558",
      "NCIT:C155790",
      "UMLS:C2062986"
    ],
    "synonyms": [
      "cancer of skull",
      "malignant neoplasm of skull",
      "malignant skull neoplasm",
      "skull cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A malignant neoplasm involving the skull."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4262,
      "label": "bone cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3041,
        18958
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2019-1041",
          "DOID:184",
          "EFO:1000350",
          "GARD:0023070",
          "ICD9:170.9",
          "MEDGEN:79002",
          "MESH:D001859",
          "NCIT:C4016",
          "SCTID:428281000",
          "UMLS:C0279530"
        ],
        "synonyms": [
          "bone neoplasm",
          "bone tumor",
          "bone tumour",
          "osseous tumor",
          "osseous tumour",
          "bone cancer",
          "cancer of bone",
          "cancer of skeletal element",
          "cancer of the bone",
          "malignant bone neoplasm",
          "malignant bone tumor",
          "malignant neoplasm of bone",
          "malignant neoplasm of skeletal element",
          "malignant neoplasm of the bone",
          "malignant osseous neoplasm",
          "malignant osseous tumor",
          "malignant osseous tumour",
          "malignant skeletal element neoplasm",
          "malignant tumor of bone",
          "malignant tumor of the bone",
          "malignant tumour of bone",
          "malignant tumour of the bone",
          "osseous cancer",
          "skeletal element cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the bone or articular cartilage."
      },
      "child_count": 24,
      "reference_id": "MONDO:0002129"
    },
    {
      "id": 7266,
      "label": "head and neck cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7231
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11934",
          "EFO:0006859",
          "MEDGEN:78920",
          "NCIT:C4013",
          "UMLS:C0278996"
        ],
        "synonyms": [
          "head and neck neoplasm",
          "head and neck tumors",
          "head and neck tumours",
          "head/neck neoplasm",
          "tumour of head and neck",
          "cancer of craniocervical region",
          "cancer of head and neck",
          "cancer of the head and neck",
          "craniocervical region cancer",
          "head and neck cancer",
          "head and neck malignant neoplasia",
          "malignant craniocervical region neoplasm",
          "malignant head and neck neoplasm",
          "malignant head and neck tumor",
          "malignant head and neck tumour",
          "malignant neoplasm of craniocervical region",
          "malignant neoplasm of head and neck",
          "malignant neoplasm of the head and neck",
          "malignant tumor of head and neck",
          "malignant tumor of the head and neck",
          "malignant tumour of head and neck",
          "malignant tumour of the head and neck"
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0005627"
    },
    {
      "id": 21561,
      "label": "skull neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7231,
        18958,
        21562
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025448",
          "ICD9:239.2",
          "MEDGEN:11457",
          "MESH:D012888",
          "NCIT:C3375",
          "SCTID:126538005",
          "UMLS:C0037305"
        ],
        "synonyms": [
          "neoplasm of skull",
          "neoplasm of the skull",
          "skull neoplasm",
          "skull tumor",
          "skull tumour",
          "tumor of skull",
          "tumor of the skull",
          "tumour of skull",
          "tumour of the skull"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the bones and structures of the skull."
      },
      "child_count": 21,
      "reference_id": "MONDO:0024653"
    }
  ],
  "children": [
    {
      "id": 4246,
      "label": "pituitary cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4265,
        4279,
        5646,
        17888,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1785",
          "EFO:0005578",
          "GARD:0023064",
          "ICD10CM:C75.1",
          "MEDGEN:96922",
          "NCIT:C4769",
          "SCTID:363482009",
          "UMLS:C0496842",
          "icd11.foundation:1130461249"
        ],
        "synonyms": [
          "pituitary gland neoplasm",
          "pituitary neoplasm",
          "cancer of pituitary gland",
          "malignant neoplasm of pituitary",
          "malignant neoplasm of pituitary gland",
          "malignant neoplasm of the pituitary",
          "malignant neoplasm of the pituitary gland",
          "malignant pituitary gland neoplasm",
          "malignant pituitary gland tumor",
          "malignant pituitary gland tumour",
          "malignant pituitary neoplasm",
          "malignant pituitary tumor",
          "malignant pituitary tumour",
          "malignant tumor of pituitary",
          "malignant tumor of pituitary gland",
          "malignant tumor of the pituitary",
          "malignant tumor of the pituitary gland",
          "malignant tumour of pituitary",
          "malignant tumour of pituitary gland",
          "malignant tumour of the pituitary",
          "malignant tumour of the pituitary gland",
          "pituitary cancer",
          "pituitary gland cancer",
          "pituitary neoplasms, malignant",
          "pituitary tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the pituitary gland. Representative examples include functioning or non-functioning carcinomas arising from the anterior lobe of the pituitary gland, chordomas, chondrosarcomas, and metastatic carcinomas from the breast, lung, and gastrointestinal tract."
      },
      "child_count": 20,
      "reference_id": "MONDO:0002109"
    },
    {
      "id": 4264,
      "label": "jaw cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4265,
        4587,
        20677
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1862",
          "GARD:0023072",
          "MEDGEN:155838",
          "MESH:D007573",
          "UMLS:C0751255",
          "icd11.foundation:1535116870"
        ],
        "synonyms": [
          "jaw neoplasm",
          "neoplasm of jaw",
          "cancer of jaw skeleton",
          "jaw skeleton cancer",
          "malignant jaw skeleton neoplasm",
          "malignant neoplasm of jaw skeleton"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the jaw skeleton"
      },
      "child_count": 9,
      "reference_id": "MONDO:0002131"
    },
    {
      "id": 4902,
      "label": "orbital cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4265,
        21526
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4143",
          "EFO:0007408",
          "GARD:0023289",
          "ICD10CM:C69.6",
          "ICD9:190.1",
          "ICD9:239.89",
          "MEDGEN:56314",
          "NCIT:C3562",
          "SCTID:127003006",
          "UMLS:C0153626",
          "icd11.foundation:1872149350"
        ],
        "synonyms": [
          "neoplasm of orbit proper",
          "orbital tumor",
          "orbital tumour",
          "cancer of orbit of skull",
          "malignant neoplasm of orbit",
          "malignant neoplasm of orbit of skull",
          "malignant neoplasm of the orbit",
          "malignant orbit neoplasm",
          "malignant orbit of skull neoplasm",
          "malignant orbit tumor",
          "malignant orbit tumour",
          "malignant orbital neoplasm",
          "malignant orbital tumor",
          "malignant orbital tumour",
          "malignant tumor of orbit",
          "malignant tumor of the orbit",
          "malignant tumour of orbit",
          "malignant tumour of the orbit",
          "orbit of skull cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the orbit."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002889"
    },
    {
      "id": 4903,
      "label": "skull base chordoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4265,
        4813,
        10236
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4151",
          "GARD:0023290",
          "MEDGEN:233448",
          "NCIT:C5453",
          "UMLS:C1335975"
        ],
        "synonyms": [
          "chordoma of skull base",
          "chordoma of the skull base",
          "skull base chordoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A slow-growing malignant bone tumor arising from the remnants of the notochord and occurring in the base of the skull. It is characterized by a lobulated growth pattern, myxoid stroma formation, and the presence of physaliphorous cells.."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002892"
    },
    {
      "id": 7833,
      "label": "malignant jugulotympanic paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4233,
        4265,
        4753,
        6420,
        20305,
        20310,
        20329,
        21452,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024363",
          "MEDGEN:87584",
          "NCIT:C4623",
          "UMLS:C0347856"
        ],
        "synonyms": [
          "cancer of jugular body",
          "jugular body cancer",
          "malignant glomus jugulare neoplasm",
          "malignant glomus jugulare tumor",
          "malignant glomus jugulare tumour",
          "malignant jugular body neoplasm",
          "malignant jugulotympanic paraganglioma",
          "malignant neoplasm of glomus jugulare",
          "malignant neoplasm of jugular body",
          "malignant neoplasm of the glomus jugulare",
          "malignant tumor of glomus jugulare",
          "malignant tumor of the glomus jugulare",
          "malignant tumour of glomus jugulare",
          "malignant tumour of the glomus jugulare"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A jugulotympanic paraganglioma that metastasizes to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006291"
    },
    {
      "id": 20081,
      "label": "paranasal sinus cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2875,
        3050,
        4265,
        6984
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025207",
          "MEDGEN:56305",
          "NCIT:C7487",
          "UMLS:C0153474"
        ],
        "synonyms": [
          "malignant accessory sinus neoplasm",
          "malignant accessory sinus tumor",
          "malignant accessory sinus tumour",
          "malignant neoplasm of accessory sinus",
          "malignant neoplasm of paranasal sinus",
          "malignant neoplasm of the accessory sinus",
          "malignant neoplasm of the paranasal sinus",
          "malignant paranasal sinus neoplasm",
          "malignant paranasal sinus tumor",
          "malignant paranasal sinus tumour",
          "malignant tumor of accessory sinus",
          "malignant tumor of paranasal sinus",
          "malignant tumor of the accessory sinus",
          "malignant tumor of the paranasal sinus",
          "malignant tumour of accessory sinus",
          "malignant tumour of paranasal sinus",
          "malignant tumour of the accessory sinus",
          "malignant tumour of the paranasal sinus"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the paranasal sinuses."
      },
      "child_count": 8,
      "reference_id": "MONDO:0020669"
    }
  ],
  "roots": [
    {
      "id": 4262,
      "label": "bone cancer"
    },
    {
      "id": 7266,
      "label": "head and neck cancer"
    },
    {
      "id": 21561,
      "label": "skull neoplasm"
    }
  ]
}