{
  "id": 4268,
  "label": "optic nerve disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002135",
  "properties": {
    "xrefs": [
      "DOID:1891",
      "ICD9:377.49",
      "ICD9:377.9",
      "MEDGEN:854546",
      "MESH:D009901",
      "NCIT:C79698",
      "SCTID:77157004",
      "UMLS:C3887709"
    ],
    "synonyms": [
      "cranial nerve II disease",
      "cranial nerve II disease or disorder",
      "disease of cranial nerve II",
      "disease or disorder of cranial nerve II",
      "disorder of cranial nerve II",
      "optic nerve disorder",
      "second cranial nerve disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4657,
      "label": "central nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:331",
          "EFO:0009386",
          "MEDGEN:892343",
          "MESH:D002493",
          "NCIT:C2934",
          "SCTID:23853001",
          "UMLS:C4021765"
        ],
        "synonyms": [
          "CNS disorder",
          "central nervous disease",
          "central nervous system disease",
          "central nervous system disease or disorder",
          "central nervous system disorder",
          "disease of central nervous system",
          "disease of the central nervous system",
          "disease or disorder of central nervous system",
          "disorder of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the central nervous system."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002602"
    },
    {
      "id": 5469,
      "label": "cranial nerve neuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5656",
          "ICD9:352.9",
          "MEDGEN:1160",
          "MESH:D003389",
          "NCIT:C26733",
          "SCTID:73013002",
          "UMLS:C0010266"
        ],
        "synonyms": [
          "cranial nerve disease",
          "cranial nerve disorder",
          "cranial neuron projection bundle disease",
          "cranial neuron projection bundle disease or disorder",
          "cranial neuropathy",
          "disease of cranial neuron projection bundle",
          "disease or disorder of cranial neuron projection bundle",
          "disorder of cranial nerve",
          "disorder of cranial neuron projection bundle"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neoplastic or non-neoplastic disorder that affects one of the cranial nerves."
      },
      "child_count": 17,
      "reference_id": "MONDO:0003569"
    },
    {
      "id": 21415,
      "label": "disorder of visual system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "SCTID:128127008"
        ],
        "synonyms": [
          "disease of visual system",
          "disease or disorder of visual system",
          "disorder of visual system",
          "visual system disease",
          "visual system disease or disorder",
          "visual system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A disease that involves the visual system."
      },
      "child_count": 30,
      "reference_id": "MONDO:0024458"
    }
  ],
  "children": [
    {
      "id": 3932,
      "label": "optic disk drusen",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4268
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13561",
          "ICD10CM:H47.32",
          "ICD9:377.21",
          "MEDGEN:14495",
          "MESH:D015594",
          "SCTID:33629003",
          "UMLS:C0029128"
        ],
        "synonyms": [
          "drusen of optic disc",
          "drusen of optic disk"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Optic disk bodies composed primarily of acid mucopolysaccharides that may produce pseudopapilledema (elevation of the optic disk without associated intracranial hypertension) and visual field deficits. Drusen may also occur in the retina (see retinal drusen). (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p355)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0001746"
    },
    {
      "id": 4691,
      "label": "optic nerve neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4268,
        4684,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3419",
          "EFO:1001073",
          "ICD9:239.7",
          "MEDGEN:101181",
          "MESH:D019574",
          "NCIT:C4801",
          "SCTID:395505000",
          "UMLS:C0524802"
        ],
        "synonyms": [
          "cranial nerve II neoplasm",
          "cranial nerve II neoplasm (disease)",
          "cranial nerve II neoplasms",
          "cranial nerve II tumor",
          "cranial nerve II tumour",
          "neoplasm of cranial nerve II",
          "neoplasm of optic nerve",
          "neoplasm of second cranial nerve",
          "neoplasm of the optic nerve",
          "neoplasm of the second cranial nerve",
          "neoplasms, optic nerve",
          "neoplasms, second cranial nerve",
          "optic nerve neoplasm",
          "optic nerve neoplasms",
          "optic nerve tumor",
          "optic nerve tumour",
          "second cranial nerve neoplasm",
          "second cranial nerve neoplasms",
          "second cranial nerve tumor",
          "second cranial nerve tumour",
          "tumor of cranial nerve II",
          "tumor of optic nerve",
          "tumor of second cranial nerve",
          "tumor of the optic nerve",
          "tumor of the second cranial nerve",
          "tumour of cranial nerve II",
          "tumour of second cranial nerve",
          "tumour of the optic nerve",
          "tumour of the second cranial nerve"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Benign and malignant neoplasms which arise from or metastasize to the optic or second cranial nerve which extends from the optic disk of the eye and joins the optic chiasm. Clinical features may include visual loss, proptosis, and local pain. The majority of optic nerve tumors or optic gliomas."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002640"
    },
    {
      "id": 5501,
      "label": "optic atrophy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4268
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5723",
          "ICD10CM:H47.2",
          "ICD9:377.1",
          "ICD9:377.10",
          "MEDGEN:18180",
          "MESH:D009896",
          "NCIT:C34863",
          "SCTID:76976005",
          "UMLS:C0029124",
          "icd11.foundation:568505454"
        ],
        "synonyms": [
          "atrophy of optic disk"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A disorder characterized by loss of optic nerve fibers. It may be inherited or acquired. Acquired causes include ischemia, optic nerve neuropathy, glaucoma, trauma, radiation, brain tumors, and multiple sclerosis. It leads to vision disturbances."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003608"
    },
    {
      "id": 7490,
      "label": "optic neuritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4268,
        6880,
        7019
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1210",
          "EFO:0007405",
          "GARD:0027731",
          "ICD10CM:H46",
          "ICD10WHO:H46",
          "ICD9:377.3",
          "ICD9:377.30",
          "ICD9:377.39",
          "MEDGEN:18181",
          "MESH:D009902",
          "NCIT:C84950",
          "SCTID:66760008",
          "UMLS:C0029134",
          "icd11.foundation:210935787"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis, drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated."
      },
      "child_count": 15,
      "reference_id": "MONDO:0005885"
    },
    {
      "id": 8121,
      "label": "anterior ischemic optic neuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4268
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12010",
          "EFO:1000809",
          "GARD:0009790",
          "ICD9:377.41",
          "MEDGEN:199716",
          "MESH:D018917",
          "MedDRA:10068250",
          "SCTID:404659001",
          "UMLS:C0751711",
          "icd11.foundation:632323575"
        ],
        "synonyms": [
          "ischaemic optic neuropathy",
          "ischemic optic neuropathy",
          "aion",
          "optic disc infarction leading to vision loss",
          "optic disk infarction leading to vision loss"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis). Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disk is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields. The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety withaspirinor corticosteroids has not been helpful."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006649"
    },
    {
      "id": 8281,
      "label": "low tension glaucoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4268,
        7024
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13544",
          "EFO:1001022",
          "ICD9:365.12",
          "MEDGEN:56263",
          "MESH:D057066",
          "MedDRA:10024931",
          "SCTID:50485007",
          "UMLS:C0152136"
        ],
        "synonyms": [
          "normal tension glaucoma",
          "Glaucomas, Low tension",
          "Glaucomas, normal tension",
          "glaucoma, Low tension",
          "glaucoma, normal tension",
          "low tension Glaucomas",
          "normal tension Glaucomas",
          "tension Glaucomas, Low",
          "tension Glaucomas, normal",
          "tension glaucoma, Low",
          "tension glaucoma, normal"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006837"
    },
    {
      "id": 18608,
      "label": "extensive peripapillary myelinated nerve fibers",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4268,
        7019
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021842",
          "MEDGEN:1842279",
          "Orphanet:440724",
          "UMLS:C5681187"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018606"
    },
    {
      "id": 25939,
      "label": "isolated optic nerve aplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4268
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027016",
          "MEDGEN:1836872",
          "Orphanet:637064",
          "UMLS:C5816782"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare developmental defect during embryogenesis characterized by congenital absence of the optic nerve head, optic nerve fibers, retinal ganglion cells, and retinal blood vessels in a malformed eye. It often occurs unilaterally with otherwise normal brain development. In bilateral cases it is accompanied by other central nervous system malformations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0958342"
    }
  ],
  "roots": [
    {
      "id": 4657,
      "label": "central nervous system disorder"
    },
    {
      "id": 5469,
      "label": "cranial nerve neuropathy"
    },
    {
      "id": 21415,
      "label": "disorder of visual system"
    }
  ]
}