{
  "id": 4279,
  "label": "reproductive system cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0002149",
  "properties": {
    "xrefs": [
      "DOID:193",
      "MEDGEN:233668",
      "NCIT:C36076",
      "UMLS:C1334618"
    ],
    "synonyms": [
      "reproductive tumor",
      "reproductive tumour",
      "cancer of reproductive organ",
      "cancer of reproductive system",
      "malignant neoplasm of reproductive organ",
      "malignant neoplasm of reproductive system",
      "malignant reproductive organ neoplasm",
      "malignant reproductive system neoplasm",
      "reproductive organ cancer",
      "reproductive system cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A malignant neoplasm involving the reproductive organ"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 6733,
      "label": "cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050686",
          "DOID:0050687",
          "DOID:162",
          "ICD9:195.8",
          "ICD9:199",
          "ICD9:199.1",
          "ICDO:8000/3",
          "MEDGEN:14297",
          "NCIT:C9305",
          "ONCOTREE:MT",
          "SCTID:363346000",
          "UMLS:C0006826",
          "birnlex:406"
        ],
        "synonyms": [
          "CA",
          "cancer",
          "cell type cancer",
          "malignancy",
          "malignant growth",
          "malignant neoplasm",
          "malignant neoplasm (disease)",
          "malignant neoplastic disease",
          "malignant tumor",
          "malignant tumour",
          "neoplasm (disease), malignant",
          "neoplasm, malignant",
          "MT"
        ],
        "definition": "A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas."
      },
      "child_count": 33,
      "reference_id": "MONDO:0004992"
    },
    {
      "id": 7638,
      "label": "reproductive system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000051",
          "MEDGEN:64246",
          "NCIT:C3674",
          "UMLS:C0178830"
        ],
        "synonyms": [
          "neoplasm of reproductive system",
          "neoplasm of the reproductive system",
          "reproductive neoplasm",
          "reproductive system neoplasm",
          "reproductive system neoplasm (disease)",
          "reproductive system tumor",
          "reproductive system tumour",
          "reproductive tumor",
          "reproductive tumour",
          "tumor of reproductive system",
          "tumor of the reproductive system",
          "tumour of reproductive system",
          "tumour of the reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A benign or malignant, primary or metastatic neoplasm affecting the male and female reproductive system."
      },
      "child_count": 18,
      "reference_id": "MONDO:0006054"
    }
  ],
  "children": [
    {
      "id": 2876,
      "label": "malignant Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        7810
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050616",
          "ICDO:8650/3",
          "MEDGEN:83143",
          "NCIT:C4213",
          "UMLS:C0334410"
        ],
        "synonyms": [
          "Leydig cell cancer",
          "Leydig cell tumor, malignant",
          "cancer of Leydig cell",
          "malignant Leydig cell neoplasm",
          "malignant interstitial cell neoplasm",
          "malignant neoplasm of Leydig cell",
          "malignant interstitial cell tumor",
          "malignant interstitial cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A Leydig cell tumor characterized by large tumor size, the presence of cytologic atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately 10% of the testicular Leydig cell tumors show malignant characteristics and metastasize. Leydig cell tumors of the ovary follow a benign clinical course."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000377"
    },
    {
      "id": 2877,
      "label": "malignant Sertoli cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4279,
        4740
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050617",
          "ICDO:8630/3",
          "ICDO:8640/3",
          "MEDGEN:137755",
          "NCIT:C67006",
          "UMLS:C0334406"
        ],
        "synonyms": [
          "Sertoli cell tumor, malignant",
          "malignant Androblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A Sertoli cell tumor of the testis or the ovary which metastasizes to another anatomic site."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000378"
    },
    {
      "id": 3637,
      "label": "female reproductive organ cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        20384
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:120",
          "EFO:1001331",
          "ICD10CM:C51-C58",
          "ICD9:184",
          "MEDGEN:195944",
          "NCIT:C4913",
          "SCTID:126907002",
          "UMLS:C0699889"
        ],
        "synonyms": [
          "cancer of female reproductive organ",
          "female reproductive cancer",
          "female reproductive organ cancer",
          "gynecologic cancer",
          "malignant female reproductive organ neoplasm",
          "malignant female reproductive system neoplasm",
          "malignant female reproductive system tumor",
          "malignant female reproductive system tumour",
          "malignant gynecologic neoplasm",
          "malignant gynecologic tumor",
          "malignant gynecologic tumour",
          "malignant neoplasm of female reproductive organ",
          "malignant neoplasm of female reproductive system",
          "malignant neoplasm of the female reproductive system",
          "malignant tumor of female reproductive system",
          "malignant tumor of the female reproductive system",
          "malignant tumour of female reproductive system",
          "malignant tumour of the female reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0001416"
    },
    {
      "id": 3849,
      "label": "prepuce cancer",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4279,
        4907
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13168",
          "ICD10CM:C60.0",
          "ICD9:187.1",
          "MEDGEN:509336",
          "NCIT:C194356",
          "SCTID:363450006",
          "UMLS:C0153598",
          "icd11.foundation:272011035"
        ],
        "synonyms": [
          "cancer of prepuce",
          "malignant neoplasm of foreskin",
          "malignant neoplasm of prepuce",
          "malignant prepuce neoplasm",
          "malignant tumour of foreskin",
          "prepuce cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the prepuce."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001653"
    },
    {
      "id": 4246,
      "label": "pituitary cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4265,
        4279,
        5646,
        17888,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1785",
          "EFO:0005578",
          "GARD:0023064",
          "ICD10CM:C75.1",
          "MEDGEN:96922",
          "NCIT:C4769",
          "SCTID:363482009",
          "UMLS:C0496842",
          "icd11.foundation:1130461249"
        ],
        "synonyms": [
          "pituitary gland neoplasm",
          "pituitary neoplasm",
          "cancer of pituitary gland",
          "malignant neoplasm of pituitary",
          "malignant neoplasm of pituitary gland",
          "malignant neoplasm of the pituitary",
          "malignant neoplasm of the pituitary gland",
          "malignant pituitary gland neoplasm",
          "malignant pituitary gland tumor",
          "malignant pituitary gland tumour",
          "malignant pituitary neoplasm",
          "malignant pituitary tumor",
          "malignant pituitary tumour",
          "malignant tumor of pituitary",
          "malignant tumor of pituitary gland",
          "malignant tumor of the pituitary",
          "malignant tumor of the pituitary gland",
          "malignant tumour of pituitary",
          "malignant tumour of pituitary gland",
          "malignant tumour of the pituitary",
          "malignant tumour of the pituitary gland",
          "pituitary cancer",
          "pituitary gland cancer",
          "pituitary neoplasms, malignant",
          "pituitary tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the pituitary gland. Representative examples include functioning or non-functioning carcinomas arising from the anterior lobe of the pituitary gland, chordomas, chondrosarcomas, and metastatic carcinomas from the breast, lung, and gastrointestinal tract."
      },
      "child_count": 20,
      "reference_id": "MONDO:0002109"
    },
    {
      "id": 7450,
      "label": "male reproductive organ cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        21521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3856",
          "EFO:0007355",
          "ICD9:187.8",
          "ICD9:187.9",
          "MEDGEN:102279",
          "MESH:D005834",
          "NCIT:C8561",
          "SCTID:363515000",
          "UMLS:C0153606"
        ],
        "synonyms": [
          "male genital neoplasm",
          "male reproductive system neoplasm",
          "neoplasm of male genital organ",
          "tumor of male reproductive system",
          "tumour of male reproductive system",
          "cancer of male reproductive organ",
          "male reproductive organ cancer",
          "malignant Male reproductive system neoplasm",
          "malignant Male reproductive system tumor",
          "malignant Male reproductive system tumour",
          "malignant male reproductive organ neoplasm",
          "malignant neoplasm of Male reproductive system",
          "malignant neoplasm of male genital organ, site unspecified",
          "malignant neoplasm of male reproductive organ",
          "malignant neoplasm of the Male reproductive system",
          "malignant tumor of Male reproductive system",
          "malignant tumor of male genital organ",
          "malignant tumor of male reproductive system",
          "malignant tumor of the Male reproductive system",
          "malignant tumour of Male reproductive system",
          "malignant tumour of male genital organ",
          "malignant tumour of male reproductive system",
          "malignant tumour of the Male reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the male reproductive system. Representative examples include prostate carcinoma, penile carcinoma, testicular seminoma, and testicular embryonal carcinoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005836"
    },
    {
      "id": 11906,
      "label": "gonadoblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        4375,
        4558,
        7213,
        7464,
        7639
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3301",
          "ICDO:9073/1",
          "MEDGEN:104912",
          "MESH:D018238",
          "NCIT:C3754",
          "ONCOTREE:OGBL",
          "UMLS:C0206661"
        ],
        "synonyms": [
          "gonad blastoma",
          "gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A mixed germ cell/sex cord-stromal tumor characterized by the presence of large germ cells which resemble seminoma cells and small cells which resemble Sertoli or granulosa cells. It occurs in the testis and the ovary and is identified in children and adults. It is often associated with gonadal dysgenesis and abnormal karyotype."
      },
      "child_count": 12,
      "reference_id": "MONDO:0010768"
    },
    {
      "id": 21745,
      "label": "Buschke Lowenstein tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        7283,
        7597
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009663",
          "MEDGEN:473018",
          "MESH:D062688",
          "NCIT:C6371",
          "SCTID:402910001",
          "UMLS:C0276264"
        ],
        "synonyms": [
          "Buschke Lowenstein tumor",
          "giant condyloma acuminatum involving the prepuce and glans penis",
          "giant condyloma of Buschke and Lowenstein",
          "Buschke-Lowenstein tumor",
          "Buschke-Lowenstein tumour",
          "GCBL",
          "Giant condyloma Acuminatum",
          "Giant condyloma Acuminatums",
          "Giant condyloma of Buschke and Lowenstein",
          "Lowenstein tumor, Buschke",
          "anogenital type verrucous carcinoma",
          "condyloma Acuminatum, Giant",
          "condyloma Acuminatums, Giant",
          "tumor, Buschke Lowenstein",
          "tumor, Buschke-Lowenstein"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A verrucous carcinoma of the skin or mucosa that occurs in the anogenital region."
      },
      "child_count": 3,
      "reference_id": "MONDO:0027026"
    }
  ],
  "roots": [
    {
      "id": 6733,
      "label": "cancer"
    },
    {
      "id": 7638,
      "label": "reproductive system neoplasm"
    }
  ]
}